The aim was to estimate predictors and prognostic models of the nearest outcomes in moderate and severe traumatic brain injury. Authors have analyzed 75 medical histories of patients with moderate and severe traumatic brain injury. Methods of multiple linear regression and treelike classification were used for the construction of prognostic models. The most significant predictors as a part of prognostic models of the present study were: scores of the Glasgow coma scale and its elements, condition of corneal reflex, expression of pyramidal insufficiency, level of leukocytosis, levels of blood urea, urination disturbance, average heart rate. The results obtained confirm the prognostic value of the Glasgow coma scale. The additional account of the indicators characterizing the expression of inflammatory processes and organ insufficiency allows to significantly improve the prognostic models of outcomes in patients with traumatic brain injury.