The present study included 82 patients at the age from 28 to 60 years (46 women and 36 men). Radiotherapy was given to 44 patients of whom 27 presented with cardiovascular diseases (CVD) and 17 with diseases of the locomotor apparatus (LA) and concomitant dislipoproteinemia (DLP). The control group was comprised of 38 subjects (27 with CVD and 11 with LA disease + DLP). The patients received radiotherapy every other day as a series of 8-9 radon baths (water temperature 36-37 degrees C) for 10-15 min each at a radon concentration of 20-40 nCi/l (total dose 1.2 mSv). The treatment caused a significant increase of serum cholesterol (CL) and high-density lipoproteide (HDLP) levels with simultaneous reduction of the atherogenicity index and a tendency towards a decrease in the levels of total cholesterol, cholesterol of low density lipoproteides (LDLP), and triglicerides. Clinically, the desired level of arterial pressure was reached in 77.2% of the patients.