Analyze national characteristics of prevalence and association between gallstone disease (GSD) and diabetes mellitus (DM), both in the world and in Western Siberia, and some possible mechanisms of this association.
Changes in human behaviour and lifestyle over the last century have resulted in a dramatic increase in the incidence of DM and GSD worldwide, many risk factors are common to these diseases (overweight, age, arterial hypertension, dyslipidemia, etc.). In some studies it was shown a higher prevalence of gallstones among patients with DM compared with persons without DM, in others - there were no association between GSD and DM. In epidemiological study in frame of the WHO "MONICA" in the unorganized population of Novosibirsk in Western Siberia (1994-1995 years) it was shown, that in the male population aged 35-54 years found no relationship between GSD and DM, in the female population aged 25-64 the prevalence of GSD was 10,5% and among women with DM the frequency of GSD showed 37.5% (univariate analysis: OR = 5.0 (CI 2.04-12.2, p = 0.001). The association between GSD and DM in women remained in multivariate logistic regression analysis, which includes age, BMI, arterial hypertension: OR = 3.9 (95% CI 1.47-10.5, p = 0.006). In the female population aged 25-64 years the prevalence of diabetes was 6.7%, among women with gallstone disease--20.0%, p