The literature on cost-effectiveness of oral vaccination against rotavirus infection in high-income European countries is assessed in order to show which parameters are important for evaluation results and recommendations on inclusion in child immunization programs. There is a high degree of variation in results due to variation in country specific incidence rates, unit costs and assumed price of the vaccination. A determining factor is whether only costs to the health care system are included or whether a broader approach to costing is applied. A Danish discussion on this issue is pivotal.
Comment In: Ugeskr Laeger. 2012 Mar 5;174(10):673; author reply 67322500296