The authors analyzed work conditions of comprehensive school teachers according to workplace assessment. Additional studies covered opportunistic pathogens content of air in classrooms. Auxiliary medical examination evaluated health state of the teachers. Individual occupational risk was calculated with consideration of actual work conditions and health state. Comprehensive school teacher's work is characterized by constant or transitory influence by complex of occupational and work hazards that are mostly (according to to workplace assessment) increased work intensity, noise and inadequate illumination parameters. Ambient air of classrooms constantly contains high number of opportunistic pathogens, that could decrease immune system parameters and cause more droplet infections. Individual occupational risk of teachers, calculated with consideration of work conditions and health state parameters, appears to be high and proves high possibility of teachers' health damage at work. Recommendations cover evaluation of biologic factors within the workplace assessment, obligatory preliminary (before employment) and periodic medical examinations for comprehensive school teachers as for workers exposed to occupational hazards.