Department of Medicine, Queen Elizabeth II Health Sciences Center and the Department of Community Health and Epidemiology, Research Methods Unit, Dalhousie University, Halifax, Nova Scotia, Canada. email@example.com
Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):706-13
Underuse of implantable defibrillators has been previously noted in patients at risk for sudden cardiac death, as well as for survivors of sudden cardiac death. We sought to determine the utilization rates in a primary prevention implantable cardioverter-defibrillator (ICD)-eligible population and mortality in this group compared with a group that had undergone implantation of this therapy.
A retrospective cohort of patients from April 1, 2006, to December 31, 2009, was used to define a primary prevention ICD-eligible population. Two groups were compared on the basis of ICD implantation (no-ICD versus ICD). The primary outcome measure was mortality. Of the 717 patients found to be potentially eligible for a primary prevention ICD, 116 (16%) were referred. The remaining cohort of 601 patients were compared with an existing cohort of primary prevention ICD patients (n=290). A significant survival benefit was associated with primary prevention ICD implantation (hazard ratio, 0.46; 95% CI [0.33-0.64]; P
Comment In: Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):624-522895600