At the beginning of their study, first-year students, residents of the Middle Ob Region, were found to have five brain functional asymmetry profiles from motor sensory, and psychic asymmetry ratios. There was a preponderance of persons with left hemisphere predominance (59%); those with right hemisphere and mixed left/right predominance constituted 4 and 37%, respectively. There were a larger number of persons with a unilateral or mixed asymmetry profile among the girls and boys, respectively. Increased sympathetic impacts and the high level of anxiety were noted in the examinees with different types of individual asymmetry. Strained autonomic regulation and psychoemotional stress were seen in the students with unilateral hemisphere predominance to a greater extent and in those with mixed predominance to a lesser extent.