Numerous studies have suggested that statins have beneficial non-lipid-lowering effects, including reduction of systemic inflammatory response following surgery. We wanted to evaluate the effect of preoperative statin treatment on complications and operative mortality after coronary arterial revascularization.
We performed a retrospective study of 720 consecutive patients who underwent on-pump coronary artery bypass grafting (CABG) (n?=?513) or off-pump (OPCAB) (n?=?207) in Iceland from 2002-2006. Patients taking statins preoperatively (n?=?529) were compared with those not taking statins (n?=?191). Predictors of complications and operative mortality were evaluated by univariate and multivariate analysis.
Cardiovascular risk profiles were similar. However, hypertension was more common in the statin group but EuroSCORE was slightly lower. Operative mortality was significantly lower in patients taking statins (1.7% vs. 5.8%, p?