A total of 162 patients with risk factors of cardiovascular diseases were examined in our health centre. 102 of them were enrolled in the optimized program of non-medicamental prophylaxis applied under health resort and outpatient conditions during four years. The program included rational nutrition, psychotherapy, adequate locomotor activity, hydro-, gaso-, and thermotherapeutic procedures, and educational curricula. The patients of the control group were given the traditional health resort treatment. The comparison of the clinical and functional conditions of the patients in both groups revealed a significant advantage of the proposed therapeutic strategy.