Ambient air pollution has been associated with increased cardiovascular morbidity and mortality. In Reykjavik, Iceland, air pollutant concentrations exceed official health limits several times every year. The aim was to study the association of concentrations of NO2, O3, PM10, and H2S in the Reykjavik capital area with the dispensing of anti-angina pectoris medication, glyceryl trinitrate to the inhabitants.
Data on daily dispensing of glyceryl trinitrate, were retrieved from the Icelandic Medicines Registry. Data on hourly concentrations of NO2, O3, PM10, and H2S were obtained from the Environment Agency of Iceland. A case-crossover design was used, based on the dispensing of glyceryl trinitrate to 5,246 individuals (=18 years) between 2005 and 2009.
For every 10 µg/m3 increase of NO2 and O3 3-day mean concentrations, the odds ratio (OR) for daily dispensing of glyceryl trinitrates was 1.136 (95% confidence intervals (CI) 1.069-1.207) and 1.094 (95% CI 1.029-1.163) at lag 0, and OR was 1.096 (95% CI 1.029-1.168) and 1.094 (95% CI 1.028-1.166) at lag 1, respectively.
These findings suggest that NO2 and O3 ambient air concentrations may adversely affect cardiovascular health, as measured by the dispensing of glyceryl trinitrates for angina pectoris. Further, the findings suggest that data on the dispensing of medication may be a valuable health indicator when studying the effect of air pollution on cardiovascular morbidity.
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Cites: Epidemiology. 2004 Jan;15(1):46-5614712146
Cites: Environ Res. 2004 May;95(1):43-5215068929
Cites: Am J Epidemiol. 1991 Jan 15;133(2):144-531985444
Cites: Occup Environ Med. 1997 Aug;54(8):535-409326156
Cites: Environ Health Perspect. 1999 Jul;107(7):521-510378998
Cites: Proc R Soc Med. 1965 May;58:295-30014283879
Cites: Environ Health Perspect. 2005 Feb;113(2):201-615687058
Cites: Circulation. 2005 Feb 8;111(5):563-915699276
Cites: Eur J Epidemiol. 2005;20(4):351-815971508
Cites: Am Heart J. 1999 Nov;138(5 Pt 1):890-910539820
Cites: Environ Res. 1999 Oct;81(3):224-3010585018
Cites: Epidemiology. 2001 Mar;12(2):193-911246580
Cites: Epidemiology. 2001 May;12(3):355-711337606
Cites: Circulation. 2001 Jun 12;103(23):2810-511401937