The article covers history of establishment and development of social hygienic research in Industrial Medicine Research Institute with RAMSc over last 90 years. The materials deal with founders and leaders of Social Hygienic research laboratory in various periods, with history of occupational morbidity studies, with development and results of social hygienic studies, organization of occupational therapy service in Russia, studies concerning remote effects of occupational hazards through analytic epidemiology methods, with considerably restricted possibilities in studies of relationships (especially remote) between work conditions and workers' health nowadays due to implemented law on personal data and new approaches to evaluation of industrial hazards effects on health.