In an experiment with 7-d dry immersion for testing the mechanic foot and electrical muscle stimulation procedures of compensating the support load deficiency the following biochemical parameters were studied: activated partial thromboplastin time, prothrombin time, prothrombin index, international normalized ratio, thrombin time (TT), fibrinogen, soluble fibrin-monomer complexes, D-dimer (DD), plasminogen (PG); antithrombin III activity (ATIII), protein C (PC) and alpha2-antiplasmin (AP). Control subjects (immersed w/o stimulation) did not exhibit significant shifts in the hemostasis system: however, they decreased ATIII, PC and PG in the post-experimental period. Mechanic foot stimulation did not have a noteworthy effect on the hemostasis system functioning during immersion, whereas electromyostimulation increased procoagulant and fibrinolytic activity in blood plasma.