From the Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada (C.R., P.C., A.J.T., S.D., A.C., B.L.); Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (E.M.M.O.); and Cardiovascular Nutrition Laboratory, Tufts University, Boston, MA (A.H.L.).
To assess the effect of a Mediterranean diet (MedDiet) with and without weight loss (WL) on apolipoprotein B100 (apoB100) metabolism in men with metabolic syndrome.
The diet of 19 men with metabolic syndrome (age, 24-62 years) was first standardized to a North American isoenergetic control diet for 5 weeks, followed by an isoenergetic MedDiet for an additional 5 weeks under full-feeding conditions (MedDiet-WL). Participants next underwent a 20-week supervised WL program under free-living conditions (-10.2 ± 2.9% body weight; P