Interactions between antiretroviral (ARV) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population.
To investigate the association of age with potential drug-drug interactions (PDDIs) involving ARVs.
We studied ARV-treated patients attending a tertiary care center. PDDIs were classified as "red flag" (contraindicated) or "orange flag" (use with caution or dose adjustment). Logistic regression was used to determine the association of age with the occurrence of =1 PDDI.
Of 914 patients (78% male, median age 49 years), older patients (age =50 years) were on more drugs than younger patients (total 9 vs 7; P