School of Kinesiology (X.W., R.W., Y.L., P.C., S.C.), Shanghai University of Sport, Shanghai 200438, China; Department of Health Sciences (X.W., S.P., P.W., S.M.C., X.T., Y.L., S.C.), University of Jyväskylä, FIN-40014 Jyväskylä, Finland; National Center for Public Health Surveillance and Information Services (G.F.), Chinese Center for Disease Control and Prevention, Beijing 102206, China; Department of General Practice and Primary Health Care (J.G.E.), Helsinki University, and Unit of General Practice (J.G.E.), Helsinki University Central Hospital, FIN-00290 Helsinki, Finland; Folkhälsan Research Centre (J.G.E.), FIN-00250 Helsinki, Finland; Department of Medical Rehabilitation (P.W., S.M.C., M.A.), Oulu University Hospital, FIN-90221, Oulu, Finland; and Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland.
Knowledge about the interrelationship between adiposity and systemic low-grade inflammation during pubertal growth is important in detecting early signs of obesity-related metabolic disorders.
The objective of the study was to evaluate the developmental trajectories of fat mass (FM) and high sensitive C-reactive protein (hsCRP) levels and factors that could explain the relationship between FM and hsCRP in girls from prepuberty to early adulthood.
This was a 7.5-year longitudinal study.
The study was conducted at the University of Jyväskylä Sports and Health Science laboratory.
Three hundred ninety-six healthy Finnish girls aged 11.2 ± 0.8 years participated in the study.
Body composition was assessed by a dual-energy X-ray absorptiometry and serum concentrations of hsCRP, adipokines, and sex hormones by ELISA.
Both FM and hsCRP increased with age and had similar trajectories but different inter- and intravariance patterns. A joint analysis of fat distribution and hsCRP indicated that the linkage probabilities across different trajectory subgroups between regional FM and the corresponding hsCRP levels varied from 16% to 53%. In a longitudinal regression model, the common predictor for both FM and hsCRP was T (ß = .065, P