A decade ago the majority of cystic fibrosis (CF) patients in Sweden died in childhood or adolescence. However, better knowledge of the underlying defect and understanding of how to treat the symptoms have resulted in an ever increasing survival rate. The results support the idea that: 1. an intensive, comprehensive treatment is rewarding. 2. treatment or at least regular check ups at a CF-center give a better prognosis. 3. newborn screening might lead to a better prognosis.