Feasibility of cross-cultural prevention efforts hinges on extensive collaborative interaction. The statewide Indian Drug Prevention Program (IDPP) emphasis on collaboration resulted in successful delivery of a culturally tailored drug abuse prevention program to six groups of Native American youth in urban and rural communities. Procedures used by IDPP staff are detailed, and process data including attendance, participant demographics, and consumer satisfaction indices are presented. Preliminary findings suggesting positive program effects on correlates of adolescent substance use are also reported.