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Haemophilus influenzae meningitis in Manitoba and the Keewatin District, NWT: potential for mass vaccination.
https://arctichealth.org/en/permalink/ahliterature1016
Source
Canadian Medical Association Journal. 1988 Oct 15; 139(8):743-747.
Publication Type
Article
Date
1988
More detail
Author
G W Hammond
B E Rutherford
R. Malazdrewicz
N. MacFarlane
N. Pillay
R B Tate
L E Nicolle
B D Postl
H G Stiver
Author Affiliation
University of Manitoba
Source
Canadian Medical Association Journal. 1988 Oct 15; 139(8):743-747.
Date
1988
Language
English
Geographic Location
Canada
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Meningitis
Immunizations
Vaccine
Invasive Hib disease
Age Factors
Bacterial Vaccines - administration & dosage - therapeutic use
Canada
Child, Preschool
Comparative Study
Diphtheria Toxoid - administration & dosage
European Continental Ancestry Group
Evaluation Studies
Haemophilus influenzae - immunology
Humans
Immunization Schedule
Indians, North American
Infant
Inuits
Manitoba
Meningitis, Haemophilus - epidemiology - ethnology - prevention & control
Pentosephosphates - therapeutic use
Polysaccharides, Bacterial - therapeutic use
Research Support, Non-U.S. Gov't
Vaccination
Abstract
A community-based surveillance study of all central nervous system infections was carried out in Manitoba and the Keewatin District, NWT, between Apr. 1, 1981, and Mar. 31, 1984. There were 201 cases of bacterial meningitis in Manitoba over the study period, 81 (40%) caused by Haemophilus influenzae; all but one isolate tested were type b (Hib). There were nine cases of H. influenzae meningitis in the Keewatin District. The overall annual incidence rate of H. influenzae meningitis in Manitoba was 2.5/100,000; for children under 5 years the rate was 32.1/100,000. For the Keewatin District the corresponding rates were 69.6/100,000 and 530/100,000. A total of 85% and 100% of the cases of H. influenzae meningitis occurred by 24 months of age in Manitoba and the Keewatin District respectively. The age at onset was earlier in native Indian children (22 cases) and Inuit children (9 cases) than in non-native children (59 cases) (p less than 0.005); thus, vaccine prevention of Hib meningitis will likely be more difficult in native Indian and M??©tis children. Without evaluating the increased potential of H. influenzae vaccines to prevent nonmeningitic forms of disease, we concluded that mass childhood vaccination with polyribosylribitolphosphate (PRP) vaccine is not warranted in Manitoba or the Keewatin District. Immunogenicity studies suggest that administration of conjugated Hib vaccines such as PRP-D in infancy may prevent approximately one-third to two-thirds of cases of H. influenzae meningitis; these vaccines warrant consideration for use in mass childhood vaccination programs.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 1808.
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