Introduction: The National Board of Health, Denmark in 1997 published guidelines for reporting of pathology data and the Danish Pathology Register (DPR) was established. Content: DPR contains patient, pathology, and workload data. Validity and coverage: All records are subject to error tracing. The DPR covers all pathology data in Denmark. CONCLUSION: The data is used by the pathologists in the daily diagnostic process. The National Board of Health uses the data in the Danish Cancer Registry and DPR is unique for research as data can be linked to tissue biobanks and clinical databases.