This study investigates the differences between at-risk gamblers and no-risk gamblers to provide a closer inspection of the characteristics and gambling behavior of at-risk gamblers. The data stem from the first Danish large-scale nationwide study, in 2005, followed by a second wave interview in 2006. The first wave sample consists of 4,932 current gamblers with no current gambling problems or pathology, and the second wave re-interviewed 379 of them. The analysis involves both a logistic regression and cross-tabulations. The results show that at-risk gamblers and no-risk gamblers have significantly different socio-demographic profiles and gambling behaviors. At-risk gambling is more prevalent for men, young-to-middle-aged people, and immigrants, and at-risk gamblers are more likely to have low income, low education, and no children living at home. This study shows that playing high-risk games substantially increases the odds for at-risk gambling. This finding is important for all professionals involved in preventive work.