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30-year mortality after venous thromboembolism: a population-based cohort study.

https://arctichealth.org/en/permalink/ahliterature257922
Source
Circulation. 2014 Sep 2;130(10):829-36
Publication Type
Article
Date
Sep-2-2014
Author
Kirstine Kobberøe Søgaard
Morten Schmidt
Lars Pedersen
Erzsébet Horváth-Puhó
Henrik Toft Sørensen
Author Affiliation
From the Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. kks@clin.au.dk.
Source
Circulation. 2014 Sep 2;130(10):829-36
Date
Sep-2-2014
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Cohort Studies
Databases as Topic - statistics & numerical data
Denmark - epidemiology
Female
Humans
Longitudinal Studies
Male
Middle Aged
Regression Analysis
Retrospective Studies
Risk factors
Survival Rate
Venous Thromboembolism - epidemiology - mortality
Abstract
Studies on long-term mortality after venous thromboembolism (VTE) are sparse.
Using Danish medical databases, we conducted a 30-year nationwide population-based cohort study of 128 223 patients with first-time VTE (1980-2011) and a comparison cohort of 640 760 people from the general population (without VTE) randomly matched by sex, year of birth, and calendar period. The mortality risks for patients with deep venous thrombosis (DVT) and pulmonary embolism (PE) were markedly higher than for the comparison cohort during the first year, especially within the first 30 days (3.0% and 31% versus 0.4%). Using Cox regression, we assessed mortality rate ratios (MRRs) with 95% confidence intervals (CIs). The overall 30-year MRR was 1.55 (95% CI, 1.53-1.57) for DVT and 2.77 (95% CI, 2.74-2.81) for PE. The 30-day MRR was 5.38 (95% CI, 5.00-5.80) for DVT and 80.87 (95% CI, 76.02-86.02) for PE. Over time, the 30-day MRR was consistently 5- to 6-fold increased for DVT, whereas it improved for PE from 138 (95% CI, 125-153) in 1980 to 1989 to 36.08 (95% CI, 32.65-39.87) in 2000 to 2011. The 1- to 10-year and 11- to 30-year MRRs remained 25% to 40% increased after both DVT and PE but were 3- to 5-fold increased after DVT and 6- to 11-fold increased after PE when VTE was considered the immediate cause of death.
Patients with VTE are at increased risk of dying, especially within the first year after diagnosis, but also during the entire 30 years of follow-up, with VTE as an important cause of death. Although 30-day mortality after DVT remained fairly constant over the last 3 decades, it improved markedly for PE.
Notes
Comment In: Nat Rev Cardiol. 2014 Sep;11(9):49625027484
Comment In: Nat Rev Cardiol. 2014 Sep;11(9):49725027486
PubMed ID
24970783 View in PubMed
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Association between duration of untreated psychosis and brain morphology in schizophrenia within the Northern Finland 1966 Birth Cohort.

https://arctichealth.org/en/permalink/ahliterature140885
Source
Schizophr Res. 2010 Nov;123(2-3):145-52
Publication Type
Article
Date
Nov-2010
Author
Matti Penttilä
Erika Jääskeläinen
Marianne Haapea
Päivikki Tanskanen
Juha Veijola
Khanum Ridler
Graham K Murray
Anna Barnes
Peter B Jones
Matti Isohanni
Hannu Koponen
Jouko Miettunen
Author Affiliation
University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, P.O. Box 5000, FIN-90014 Oulu, Finland. mattipen@mail.student.oulu.fi
Source
Schizophr Res. 2010 Nov;123(2-3):145-52
Date
Nov-2010
Language
English
Publication Type
Article
Keywords
Adult
Brain - pathology
Diagnostic and Statistical Manual of Mental Disorders
Female
Finland - epidemiology
Follow-Up Studies
Functional Laterality
Hippocampus - pathology
Humans
Limbic System - pathology
Magnetic Resonance Imaging
Male
Medical Records Systems, Computerized
Psychotic Disorders - etiology - pathology
Regression Analysis
Schizophrenia - diagnosis - pathology
Schizophrenic Psychology
Time Factors
Abstract
Duration of untreated psychosis (DUP) has been linked with poor prognosis and changes in the brain structure in schizophrenia at least at the beginning of the disease, but it is still unknown whether DUP relates to brain morphometry in the longer term. Our aim was to analyze the relation between DUP and the brain structure in schizophrenia in the general population, after several years of illness.
Brains of subjects with psychosis from the Northern Finland 1966 Birth Cohort (NFBC 1966) were scanned with MRI during 1999-2001 after an 11-year follow-up. DUP was assessed from medical records and regressed against global and local tissue density measurements. The brain morphometric and the DUP information were available for 46 subjects with DSM-III-R schizophrenia.
The DUP did not correlate with volumes of the total gray or white matter or the cerebrospinal fluid. The length of DUP associated positively with reduced densities of the right limbic area and the right hippocampus.
Long DUP was slightly associated with reductions of gray matter densities in the limbic area and especially the hippocampus after several years follow-up, supporting the hypothesis that, compared to short DUP, long DUP might be a marker of different disease trajectories including subtle morphometric changes.
PubMed ID
20832996 View in PubMed
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Association between the duration of untreated psychosis and short- and long-term outcome in schizophrenia within the Northern Finland 1966 Birth Cohort.

https://arctichealth.org/en/permalink/ahliterature118694
Source
Schizophr Res. 2013 Jan;143(1):3-10
Publication Type
Article
Date
Jan-2013
Author
Matti Penttilä
Jouko Miettunen
Hannu Koponen
Merja Kyllönen
Juha Veijola
Matti Isohanni
Erika Jääskeläinen
Author Affiliation
University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, Oulu, Finland. mattipen@paju.oulu.fi
Source
Schizophr Res. 2013 Jan;143(1):3-10
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Association
Cohort Studies
Community Health Planning
Female
Finland - epidemiology
Hospitalization - statistics & numerical data
Humans
Longitudinal Studies
Male
Middle Aged
Psychotic Disorders - epidemiology - therapy
Regression Analysis
Schizophrenia - epidemiology - therapy
Sex Factors
Time Factors
Abstract
Long duration of untreated psychosis (DUP) may relate to poor outcome in schizophrenia. However, the associations between DUP and outcomes, particularly in later course of illness, remain unclear. Our aim was to explore the associations between DUP and short- and long-term outcomes in schizophrenia.
Data was collected for subjects with schizophrenia (n=89) in the population-based Northern Finland 1966 Birth Cohort. DUP was obtained from medical records, and its associations with short- (under 2years) and long-term clinical and social outcomes were assessed extending to 20years after the onset of the illness.
Longer DUP predicted longer length of first hospitalisation and increased the risk of rehospitalisation during the first two years. Longer DUP associated with decreased probability of disability pension, smaller amount of time spent in hospital, and higher proportion of time at work during the first 10years of the follow-up.
Regarding early outcome, long DUP may be a modest marker and proxy measure of a more severe clinical phenotype. The divergent results of earlier studies and the association between long DUP and better long-term outcome in our study, indicate that the length of DUP does not necessarily predict poor outcome in long-term follow-up. This may also be due to methodical difficulties, e.g. insufficient power and residual confounding linked to long follow-up studies.
PubMed ID
23178106 View in PubMed
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Brain structure in different psychosis risk groups in the Northern Finland 1986 birth cohort.

https://arctichealth.org/en/permalink/ahliterature262202
Source
Schizophr Res. 2014 Mar;153(1-3):143-9
Publication Type
Article
Date
Mar-2014
Author
Andres Roman-Urrestarazu
Graham K Murray
Anna Barnes
Jouko Miettunen
Erika Jääskeläinen
Pirjo Mäki
Juha Nikkinen
Jukka Remes
Sari Mukkala
Jenni Koivukangas
Markus Heinimaa
Irma Moilanen
John Suckling
Vesa Kiviniemi
Peter B Jones
Juha Veijola
Source
Schizophr Res. 2014 Mar;153(1-3):143-9
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Adult
Brain - pathology
Cohort Studies
Female
Finland
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Prodromal Symptoms
Psychiatric Status Rating Scales
Psychomotor Performance
Psychotic Disorders - classification - pathology
Questionnaires
Regression Analysis
Risk factors
Abstract
We tested the hypothesis that family risk for psychosis (FR) and clinical risk for psychosis (CR) are associated with structural brain abnormalities, with increased deficits in those at both family risk and clinical risk for psychosis (FRCR). The study setting was the Oulu Brain and Mind Study, with subjects drawn from the Northern Finland 1986 Birth Cohort (n=9479) using register and questionnaire based screening, and interviews using the Structured Interview for Prodromal Symptoms. After this procedure, 172 subjects were included in the study, classified as controls (n=73) and three risk groups: FR excluding CR (FR, n=60), CR without FR (CR, n=26), and individuals at both FR and CR (FRCR, n=13). T1-weighted brain scans were acquired and processed in a voxel-based analysis using permutation-based statistics. In the comparison between FRCR versus controls, we found lower grey matter volume (GMV) in a cluster (1689 voxels at -4.00, -72.00, -18.00mm) covering both cerebellar hemispheres and the vermis. This cluster was subsequently used as a mask to extract mean GMV in all four groups: FR had a volume intermediate between controls and FRCR. Within FRCR there was an association between cerebellar cluster brain volume and motor function. These findings are consistent with an evolving pattern of cerebellar deficits in psychosis risk with the most pronounced deficits in those at highest risk of psychosis.
PubMed ID
24462264 View in PubMed
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Changes in alcohol use in relation to sociodemographic factors in early midlife.

https://arctichealth.org/en/permalink/ahliterature275744
Source
Scand J Public Health. 2016 May;44(3):249-57
Publication Type
Article
Date
May-2016
Author
Daniel Vladimirov
Solja Niemelä
Juha Auvinen
Markku Timonen
Sirkka Keinänen-Kiukaanniemi
Leena Ala-Mursula
Jaana Laitinen
Jouko Miettunen
Source
Scand J Public Health. 2016 May;44(3):249-57
Date
May-2016
Language
English
Publication Type
Article
Keywords
Adult
Alcohol drinking - epidemiology
Educational Status
Employment - statistics & numerical data
Female
Finland - epidemiology
Humans
Male
Marital Status - statistics & numerical data
Middle Aged
Prospective Studies
Regression Analysis
Risk factors
Sex Distribution
Abstract
To describe changes in alcohol use in relation to employment, education and relationship statuses in a general population sample in early midlife using prospective birth cohort data.
In the Northern Finland Birth Cohort 1966 (N=5621) alcohol use was studied in participants at two time points: ages 31 and 46. The total mean consumption was calculated and participants were classified into steady drinkers, increasers and reducers based on the change in consumption between the ages of 31 and 46. Multinomial regression analysis was conducted with changes in employment and relationship statuses.
Daily alcohol consumption rose by 30% for men and 40% for women. Persons who were unemployed, single or had a low level of education consumed most. Of the alcohol users, 70% were classified as steady drinkers, 10% as reducers and 20% as increasers. For men, leaving a relationship (odds ratio, OR 1.5; 95% confidence interval, CI: 1.0-2.1) predicted increased alcohol use. The predictors of reducing consumption were entering a relationship for men (OR 1.9; 95% CI: 1.2-2.9) and women (OR 1.9; 95% CI: 1.1-3.1), and leaving a relationship (OR 2.6; 95% CI: 1.6-4.3) for women.
Alcohol consumption among Finns of northern origin does not seem to decline with age. Alcohol usage is fairly stable in the majority of middle-aged people. A substantial proportion of alcohol users engage in either binge or heavy drinking. Gender differences in predictors exist-- changes in relationship status predict a reduction in alcohol usage in women, whereas in men, divorce predicts an increase in usage.
PubMed ID
26685194 View in PubMed
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Comparison of outcomes of patients = 80 years of age having percutaneous coronary intervention according to presentation (stable vs unstable angina pectoris/non-ST-segment elevation myocardial infarction vs ST-segment elevation myocardial infarction).

https://arctichealth.org/en/permalink/ahliterature131661
Source
Am J Cardiol. 2011 Nov 15;108(10):1395-400
Publication Type
Article
Date
Nov-15-2011
Author
Lisbeth Antonsen
Lisette Okkels Jensen
Per Thayssen
Evald Høj Christiansen
Anders Junker
Hans-Henrik Tilsted
Christian Juhl Terkelsen
Anne Kaltoft
Michael Maeng
Knud Noerregaard Hansen
Jan Ravkilde
Jens Flensted Lassen
Morten Madsen
Henrik Toft Sørensen
Leif Thuesen
Author Affiliation
Department of Cardiology, Odense University Hospital, Odense, Denmark. dr_lissie@hotmail.com
Source
Am J Cardiol. 2011 Nov 15;108(10):1395-400
Date
Nov-15-2011
Language
English
Publication Type
Article
Keywords
Aged, 80 and over
Angina, Stable - mortality - therapy
Angina, Unstable - mortality - therapy
Angioplasty, Balloon, Coronary - statistics & numerical data - trends
Arrhythmias, Cardiac - mortality
Cohort Studies
Comorbidity
Coronary Artery Disease - mortality - therapy
Denmark - epidemiology
Female
Follow-Up Studies
Heart Failure - mortality
Humans
Male
Myocardial Infarction - mortality - therapy
Registries
Regression Analysis
Abstract
Patients = 80 years old with coronary artery disease constitute a particular risk group in relation to percutaneous coronary intervention (PCI). From 2002 through 2008 we examined the annual proportion of patients = 80 years old undergoing PCI in western Denmark, their indications for PCI, and prognosis. From 2002 through 2009 all elderly patients treated with PCI were identified in a population of 3.0 million based on the Western Denmark Heart Registry. Cox regression analysis was used to compare mortality rates according to clinical indications controlling for potential confounding. In total 3,792 elderly patients (= 80 years old) were treated with PCI and the annual proportion increased from 224 (5.4%) in 2002 to 588 (10.2%) in 2009. The clinical indication was stable angina pectoris (SAP) in 30.2%, ST-segment elevation myocardial infarction (STEMI) in 35.0%, UAP/non-STEMI in 29.7%, and "ventricular arrhythmia or congestive heart failure" in 5.1%. Overall 30-day and 1-year mortality rates were 9.2% and 18.1%, respectively. Compared to patients with SAP the adjusted 1-year mortality risk was significantly higher for patients presenting with STEMI (hazard ratio 3.86, 95% confidence interval 3.08 to 4.85), UAP/non-STEMI (hazard ratio 1.95, 95% confidence interval 1.53 to 2.50), and ventricular arrhythmia or congestive heart failure (hazard ratio 2.75, 95% confidence interval 1.92 to 3.92). In patients with SAP target vessel revascularization decreased from 7.1% in 2002 to 2.5% in 2008. In conclusion, the proportion of patients = 80 years old treated with PCI increased significantly over an 8-year period. Patients with SAP had the lowest mortality rates and rates of clinically driven target vessel revascularization decreased over time.
PubMed ID
21890087 View in PubMed
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Concomitant use of clopidogrel and statins and risk of major adverse cardiovascular events following coronary stent implantation.

https://arctichealth.org/en/permalink/ahliterature128016
Source
Br J Clin Pharmacol. 2012 Jul;74(1):161-70
Publication Type
Article
Date
Jul-2012
Author
Morten Schmidt
Martin B Johansen
Michael Maeng
Anne Kaltoft
Lisette O Jensen
Hans-Henrik Tilsted
Hans E Bøtker
John A Baron
Henrik Toft Sørensen
Author Affiliation
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus Department of Cardiology, Aarhus, Denmark. morten.schmidt@dce.au.dk
Source
Br J Clin Pharmacol. 2012 Jul;74(1):161-70
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cardiovascular Diseases - epidemiology - prevention & control
Cohort Studies
Cytochrome P-450 CYP3A - antagonists & inhibitors
Denmark
Drug Interactions
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects - therapeutic use
Male
Middle Aged
Platelet Aggregation Inhibitors - adverse effects - therapeutic use
Regression Analysis
Risk factors
Stents
Ticlopidine - adverse effects - analogs & derivatives - therapeutic use
Time Factors
Abstract
• The CYP3A4 inhibition by lipophilic statins may attenuate the effectiveness of clopidogrel. • No studies have measured drug exposure in a time-varying manner that detects discontinuation and restart of clopidogrel and statin therapy, allowing clinical quantification of the interaction effect.
• Clopidogrel and CYP3A4-metabolizing statin use were each associated with a substantially reduced rate of major adverse cardiovascular events within 12 months after coronary stent implantation. • Although we observed an interaction between use of clopidogrel and statins, statin use vs. non-use was not associated with an increased rate of major adverse cardiovascular events in patients using clopidogrel after coronary stent implantation.
To examine whether CYP3A4-metabolizing statin use modified the association between clopidogrel use and major adverse cardiovascular events (MACE) after coronary stent implantation, using time-varying drug exposure ascertainment.
We conducted this population-based cohort study in Western Denmark (population: 3 million) using medical databases. We identified all 13 001 patients with coronary stent implantation between 2002 and 2005 and their comorbidities. During 12 months of follow-up, we tracked the use of clopidogrel and CYP3A4-metabolizing statins and the rate of MACE. We used Cox regression to compute hazard ratios (HRs) controlling for potential confounders.
The rate of MACE per 1000 person years was 104 for concomitant clopidogrel and statin use, 130 for clopidogrel without statin use, 108 for statin without clopidogrel use and 446 for no use of either drug. The adjusted HR comparing clopidogrel use with non-use was 0.68 (95% confidence interval (CI) 0.58, 0.79) among statin users and 0.34 (95% CI 0.29, 0.40) among statin non-users, yielding an interaction effect (i.e. relative rate increase) of 1.97 (95% CI 1.59, 2.44). The adjusted HR for MACE comparing statin use with non-use was 0.97 (95% CI 0.83, 1.13) among clopidogrel users and 0.49 (95% CI 0.42, 0.57) among clopidogrel non-users.
Clopidogrel and CYP3A4-metabolizing statin use were each associated with a substantially reduced rate of MACE within 12 months after coronary stent implantation. Although we observed an interaction between use of clopidogrel and statins, statin use vs. non-use was not associated with an increased rate of MACE in patients using clopidogrel after coronary stent implantation.
Notes
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PubMed ID
22243420 View in PubMed
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Culprit only or multivessel percutaneous coronary interventions in patients with ST-segment elevation myocardial infarction and multivessel disease.

https://arctichealth.org/en/permalink/ahliterature121329
Source
EuroIntervention. 2012 Aug;8(4):456-64
Publication Type
Article
Date
Aug-2012
Author
Lisette Okkels Jensen
Per Thayssen
Dóra Körmendiné Farkas
Mikkel Hougaard
Christian Juhl Terkelsen
Hans-Henrik Tilsted
Michael Maeng
Anders Junker
Jens Flensted Lassen
Erzsébet Horváth-Puhó
Henrik Toft Sørensen
Leif Thuesen
Author Affiliation
Department of Cardiology, Odense University Hospital, Denmark. okkels@dadlnet.dk
Source
EuroIntervention. 2012 Aug;8(4):456-64
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Aged
Cohort Studies
Denmark
Electrocardiography
Female
Humans
Male
Middle Aged
Myocardial Infarction - mortality - therapy
Percutaneous Coronary Intervention - methods
Registries
Regression Analysis
Retrospective Studies
Time Factors
Treatment Outcome
Vascular Diseases - mortality - therapy
Abstract
In patients with ST-segment elevation myocardial infarction (STEMI), timely reperfusion with primary percutaneous coronary intervention (PPCI) is the preferred treatment. However, it remains unclear whether the optimal strategy is complete revascularisation or culprit vessel PPCI only.
From January 2002 to June 2009 all patients treated with PPCI were identified from the Western Denmark Heart Registry. We examined mortality according to timing of multivessel PCI: acute procedure, staged procedure during the index hospitalisation, or staged procedure performed within 60 days. The hazard ratio (HR) for death was estimated using a time-dependent Cox regression model, with time of PCI for the non-culprit lesion as the time-dependent variable. The study cohort consisted of 5,944 patients, of whom 4,770 (80%) had single-vessel disease and 1,174 (20%) had multivessel PCI within 60 days. Among 354 (30.2%) patients with acute multivessel PCI, 194 (16.5%) patients with multivessel PCI during the index hospitalisation, and 626 (53.3%) patients with multivessel PCI within 60 days after the index hospitalisation, the adjusted HRs for one-year mortality were 1.53 (95% confidence interval (CI): 1.07-2.18), 0.60 (95% CI: 0.28-1.26), and 0.28 (95% CI: 0.14-0.54), respectively, compared to patients with single vessel disease.
Acute multivessel PCI in patients with STEMI was associated with increased mortality.
Notes
Comment In: EuroIntervention. 2012 Aug;8(4):423-522917723
PubMed ID
22917729 View in PubMed
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Declining risk of triple-class antiretroviral drug failure in Danish HIV-infected individuals.

https://arctichealth.org/en/permalink/ahliterature7161
Source
AIDS. 2005 May 20;19(8):815-22
Publication Type
Article
Date
May-20-2005
Author
Nicolai Lohse
Niels Obel
Gitte Kronborg
Alex Laursen
Court Pedersen
Carsten S Larsen
Birgit Kvinesdal
Henrik Toft Sørensen
Jan Gerstoft
Author Affiliation
Odense University Hospital, and University of Southern Denmark, Odense, Denmark. nicolai.lohse@ouh.fyns-amt.dk
Source
AIDS. 2005 May 20;19(8):815-22
Date
May-20-2005
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Cohort Studies
Denmark
Female
HIV Infections - drug therapy - mortality - virology
HIV-1
Humans
Male
Middle Aged
Regression Analysis
Research Support, Non-U.S. Gov't
Risk
Survival Rate
Treatment Failure
Viral Load
Abstract
OBJECTIVES: To analyse the incidence, prevalence, and predictors for development of triple-class antiretroviral drug failure (TCF) in individuals infected with HIV. DESIGN: Population-based observational cohort study from 1 January 1995 to 31 December 2003, focusing on all 2722 recipients of highly active antiretroviral therapy (HAART) in Denmark. METHODS: We used person-years analysis, Kaplan-Meier survival curves and Cox regression analysis. TCF was defined as a minimum of 120 days with viral load > 1000 copies/ml on treatment with each of the three major drug classes. RESULTS: We observed 177 TCFs, yielding a crude incidence rate (IR) of 1.8 per 100 person-years [95% confidence interval (CI), 1.6-2.1]. Seven years after initiation of HAART, 17.2% (95% CI, 14.5-20.5) of antiretroviral (ART)-experienced patients, but only 7.0% (95% CI, 4.3-11.2) of ART-naive patients were estimated to have failed. After an initial rise, the IR from the third to the sixth year of HAART declined significantly for ART-experienced patients [incidence rate ratio (IRR), 0.80 per year (95% CI, 0.66-0.97); P = 0.022], and non-significantly for ART-naive patients [IRR, 0.79 per year (95% CI, 0.53-1.18); P = 0.255]. The IR for all patients being followed each year declined from 1997 to 2003 [IRR, 0.88 (95% CI, 0.81-0.96); P = 0.002]. The prevalence of TCF remained stable at less than 7% after 2000. Predictors of TCF at commencement of HAART were a CD4 cell count below 200, a previous AIDS-defining event, previous antiretroviral exposure, earlier year of HAART initiation, and young age. CONCLUSIONS: The risk of TCF is declining in Denmark and the prevalence remains stable.
PubMed ID
15867496 View in PubMed
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Early-life origins of schizotypal traits in adulthood.

https://arctichealth.org/en/permalink/ahliterature149354
Source
Br J Psychiatry. 2009 Aug;195(2):132-7
Publication Type
Article
Date
Aug-2009
Author
Jari Lahti
Katri Raïkkönen
Ulla Sovio
Jouko Miettunen
Anna-Liisa Hartikainen
Anneli Pouta
Anja Taanila
Matti Joukamaa
Marjo-Riitta Järvelin
Juha Veijola
Author Affiliation
Department of Psychology, University of Helsinki, FI 00014 University of Helsinki, Finland. jari.lahti@helsinki.fi
Source
Br J Psychiatry. 2009 Aug;195(2):132-7
Date
Aug-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Birth Order
Birth weight
Body Size
Cephalometry - statistics & numerical data
Cohort Studies
Disease Susceptibility
Female
Finland
Humans
Infant
Infant, Newborn
Male
Organ Size
Placenta - anatomy & histology
Pregnancy - psychology
Prenatal Exposure Delayed Effects - epidemiology
Questionnaires
Regression Analysis
Risk factors
Schizotypal Personality Disorder - etiology
Seasons
Sex Factors
Smoking - epidemiology
Abstract
Although schizotypal traits, such as anhedonia and aberrant perceptions, may increase the risk for schizophrenia-spectrum disorders, little is known about early-life characteristics that predict more pronounced schizotypal traits.
To examine whether birth size or several other early-life factors that have been previously linked with schizophrenia predict schizotypal traits in adulthood.
Participants of the Northern Finland 1966 Birth Cohort Study (n = 4976) completed a questionnaire on positive and negative schizotypal traits at the age of 31 years.
Lower placental weight, lower birth weight and smaller head circumference at 12 months predicted elevated positive schizotypal traits in women after adjusting for several confounders (P
PubMed ID
19648543 View in PubMed
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