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Atrial fibrillation or flutter and stroke: a Danish population-based study of the effectiveness of oral anticoagulation in clinical practice.

https://arctichealth.org/en/permalink/ahliterature47529
Source
J Intern Med. 2002 Jul;252(1):64-9
Publication Type
Article
Date
Jul-2002
Author
L. Frost
S P Johnsen
L. Pedersen
E. Toft
S. Husted
H T Sørensen
Author Affiliation
Department of Clinical Epidemiology, Aarhus University Hospital and Aalborg Sygehus, Denmark. lars.frost@aas.auh.dk
Source
J Intern Med. 2002 Jul;252(1):64-9
Date
Jul-2002
Language
English
Publication Type
Article
Keywords
Administration, Oral
Aged
Aged, 80 and over
Anticoagulants - therapeutic use
Atrial Fibrillation - drug therapy
Atrial Flutter - drug therapy
Cerebrovascular Accident - epidemiology - prevention & control
Cohort Studies
Comorbidity
Denmark - epidemiology
Female
Humans
Incidence
Male
Middle Aged
Randomized Controlled Trials
Registries
Regression Analysis
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVES: A pooled analysis of randomized trials has shown that oral anticoagulation therapy reduces the risk of ischaemic stroke with 68% in patients with atrial fibrillation. We examined the effectiveness of oral anticoagulation on risk of stroke of any nature (fatal and nonfatal ischaemic and/or haemorrhagic stroke) in patients with nonvalvular atrial fibrillation or flutter living in the County of North Jutland, Denmark. DESIGN: Cohort study. SUBJECTS AND METHODS: We used the Hospital Discharge Registry covering the county (490 000 inhabitants) from 1991 to 1998 to identify 2699 men and 2425 women with atrial fibrillation or flutter, aged 60-89 years. Data on prescriptions of anticoagulation were obtained from the National Health Service. We defined use of oral anticoagulation as date of prescription or reiteration plus 90 days. Patients were followed in the County Hospital Discharge Registry until a diagnosis of stroke (fatal and nonfatal ischaemic and/or haemorrhagic stroke), emigration, death or the end of 1998. We used Cox regression analyses to estimate the relative risk of stroke associated with use of oral anticoagulation compared with no use, adjusted for age, diabetes and underlying cardiovascular diseases. RESULTS: Eight hundred and thirty-eight of 2699 men (31%) and 552 of 2425 women (23%) with atrial fibrillation had one or more recorded prescriptions of oral anticoagulation. The incidence rates of stroke were 31 per 1000 person-years of follow-up in men, and 30 per 1000 person-years of follow-up in women. The adjusted relative risks of stroke during anticoagulation were 0.6 [95% confidence interval (CI) 0.4-1.0] in men, and 1.0 (95% CI 0.7-1.6) in women compared with nonuse periods. CONCLUSIONS: The effectiveness of oral anticoagulation in clinical practice may be lesser than the efficacy of oral anticoagulation reported from randomized trials.
Notes
Comment In: J Intern Med. 2003 Jan;253(1):92-312588541
PubMed ID
12074740 View in PubMed
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Does month of birth affect risk of Crohn's disease in childhood and adolescence?

https://arctichealth.org/en/permalink/ahliterature31918
Source
BMJ. 2001 Oct 20;323(7318):907
Publication Type
Article
Date
Oct-20-2001
Author
H T Sørensen
L. Pedersen
B. Nørgård
K. Fonager
K J Rothman
Author Affiliation
Department of Clinical Epidemiology, Aarhus and Aalborg University Hospital, Vennelyst Blvd. Denmark. hts@soci.au.dk
Source
BMJ. 2001 Oct 20;323(7318):907
Date
Oct-20-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Chi-Square Distribution
Child
Communicable Diseases - complications
Crohn Disease - etiology
Denmark
Humans
Infant, Newborn
Regression Analysis
Risk factors
Seasons
PubMed ID
11668136 View in PubMed
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Postoperative mortality in patients with liver cirrhosis undergoing transurethral resection of the prostate: a Danish nationwide cohort study.

https://arctichealth.org/en/permalink/ahliterature196037
Source
BJU Int. 2001 Feb;87(3):183-6
Publication Type
Article
Date
Feb-2001
Author
S S Nielsen
A M Thulstrup
L. Lund
H. Vilstrup
H T Sørensen
Author Affiliation
Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark.
Source
BJU Int. 2001 Feb;87(3):183-6
Date
Feb-2001
Language
English
Publication Type
Article
Keywords
Aged
Cohort Studies
Confidence Intervals
Denmark - epidemiology
Follow-Up Studies
Humans
Liver Cirrhosis - complications - mortality
Male
Odds Ratio
Postoperative Complications - mortality
Prostatic Hyperplasia - complications - surgery
Regression Analysis
Risk factors
Survival Analysis
Transurethral Resection of Prostate - contraindications - mortality
Treatment Outcome
Abstract
To examine the risk of 30-day postoperative mortality from transurethral resection of the prostate (TURP) in patients with liver cirrhosis, who are reportedly at considerably increased perioperative risk.
For the period 1 January 1977 to 31 December 1993, a population-based cohort was identified comprising Danish patients diagnosed with liver cirrhosis and a random sample of Danes also undergoing TURP. Logistic regression models were used to estimate the association between liver cirrhosis, age, type of admission, comorbidity and 30-day mortality.
In a cohort of 23 133 patients with liver cirrhosis, 30 underwent TURP; 150 controls with no liver cirrhosis also underwent the same procedure. Of the patients with liver cirrhosis, 6.7% died within 30 days of TURP; the estimated adjusted odds ratio was 3.0 (95% confidence interval 0.4-22.9) for the 30-day postoperative mortality in patients with liver cirrhosis compared with patients without (mortality 2%). Advanced age, comorbidity and acute admission seemed to be associated with an increased postoperative mortality.
This study indicates that TURP in patients with liver cirrhosis was associated with increased mortality.
PubMed ID
11167639 View in PubMed
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Prenatal exposure to acid-suppressive drugs and the risk of childhood asthma: a population-based Danish cohort study.

https://arctichealth.org/en/permalink/ahliterature125886
Source
Aliment Pharmacol Ther. 2012 May;35(10):1190-8
Publication Type
Article
Date
May-2012
Author
A B T Andersen
R. Erichsen
D K Farkas
F. Mehnert
V. Ehrenstein
H T Sørensen
Author Affiliation
Department of Clinical Epidemiology, Aarhus University Hospital, Denmark. abta@dce.au.dk
Source
Aliment Pharmacol Ther. 2012 May;35(10):1190-8
Date
May-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asthma - chemically induced - epidemiology
Child
Child, Preschool
Cohort Studies
Denmark - epidemiology
Female
Follow-Up Studies
Gastroesophageal Reflux - drug therapy
Histamine H2 Antagonists - adverse effects
Humans
Infant
Male
Maternal Age
Middle Aged
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology
Proton Pump Inhibitors - adverse effects
Regression Analysis
Risk factors
Young Adult
Abstract
Proton pump inhibitors (PPIs) may activate the immune system and cause asthma.
To investigate the association of prenatal exposure to PPIs and histamine 2-receptor antagonists (H2RAs) with risk of asthma.
In this cohort study, 197,060 singletons born between 1996 and 2008 in northern Denmark were followed until the end of 2009. Data were obtained through Danish medical registries. Asthma in offspring was defined as at least two prescriptions of both a ß-agonist and an inhaled glucocorticoid and/or a hospital diagnosis of asthma during the follow-up. Cox proportional-hazard regression was used to compute incidence rate ratios, adjusting for covariates.
A total of 2238 (1.1%) children were prenatally exposed to PPIs and 24,506 (12.4%) children developed asthma during follow-up (median follow-up = 6.8 years). The adjusted IRR (aIRR) of asthma associated with prenatal exposure to PPIs was 1.41 (95% confidence interval (CI): 1.27-1.56), compared with those unexposed. The association did not vary by trimester of exposure, and prenatal exposure to H2RAs was associated with similar increase in risk. The aIRR for maternal PPI and H2RA use in the year after, but not during pregnancy was 1.32 (95% CI: 1.20-1.46) and 1.13 (0.93-1.36), respectively, compared with non-use during and in the year after pregnancy.
Prenatal exposure to both PPIs and H2RAs was associated with an increased risk of asthma in our study. Because the observed association is not drug specific and also observed for maternal postnatal use it may be explained by a 'class effect' or maternal underlying condition.
PubMed ID
22443179 View in PubMed
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Risk factors associated with retinopathy of prematurity (ROP) in northern Jutland, Denmark 1990-1993.

https://arctichealth.org/en/permalink/ahliterature59201
Source
Acta Ophthalmol Scand. 1996 Jun;74(3):306-10
Publication Type
Article
Date
Jun-1996
Author
H. Nødgaard
H. Andreasen
H. Hansen
H T Sørensen
Author Affiliation
Department of Paediatrics, Aalborg Hospital, Denmark.
Source
Acta Ophthalmol Scand. 1996 Jun;74(3):306-10
Date
Jun-1996
Language
English
Publication Type
Article
Keywords
Birth weight
Denmark - epidemiology
Female
Gestational Age
Humans
Incidence
Infant, Newborn
Male
Regression Analysis
Retinopathy of Prematurity - classification - epidemiology
Risk factors
Sex Factors
Abstract
This population-based, historical, follow-up study analysed possible risk factors for retinopathy of prematurity (ROP) and resulting visual impairment in newborns over a period of 3 1/2 years in the County of Northern Jutland, Denmark. The study subjects were 141 infants with birth weight
PubMed ID
8828733 View in PubMed
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The safety of proton pump inhibitors in pregnancy.

https://arctichealth.org/en/permalink/ahliterature64046
Source
Aliment Pharmacol Ther. 1999 Aug;13(8):1085-9
Publication Type
Article
Date
Aug-1999
Author
G L Nielsen
H T Sørensen
A M Thulstrup
U. Tage-Jensen
C. Olesen
A. Ekbom
Author Affiliation
Department of Internal Medicine M, Aalborg Hospital, Aalborg, Denmark. gln@get2net.dk
Source
Aliment Pharmacol Ther. 1999 Aug;13(8):1085-9
Date
Aug-1999
Language
English
Publication Type
Article
Keywords
Abnormalities, Drug-Induced - epidemiology
Adult
Databases
Denmark
Enzyme Inhibitors - adverse effects
Female
Humans
Pregnancy
Pregnancy Complications - drug therapy
Prescriptions, Drug
Proton Pumps - antagonists & inhibitors
Regression Analysis
Research Support, Non-U.S. Gov't
Risk assessment
Treatment Outcome
Abstract
AIM: To assess the safety of proton pump inhibitors during pregnancy. METHODS: Fifty-one pregnant women exposed to proton pump inhibitors around the time of conception or during pregnancy were compared with 13 327 controls without exposure to any prescribed drug in a population-based study based on The Pharmaco-Epidemiological Prescription Database of North Jutland and the Danish Hospital Discharge Registry. RESULTS: Three babies with malformations were found among 38 women exposed to proton pump inhibitors from 30 days before conception to the end of the first trimester. No cases of stillbirth were recorded. Crude relative risks of malformation, low birth weight and preterm delivery were 1.6 (95% CI: 0.5-5.1), 1.8 (95% CI: 0.2-13.0) and 2.3 (95% CI: 0.9-6.0), respectively. CONCLUSIONS: In this population-based follow-up study, we found no substantially elevated risk in terms of malformations, low birth weight or number of preterm deliveries in pregnancies exposed to proton pump inhibitors. However, further monitoring is warranted in order to establish or rule out a potential association between the use of proton pump inhibitors and increased risk of either cardiac malformations or preterm birth.
PubMed ID
10468685 View in PubMed
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Waist circumference and body mass index as predictors of elevated alanine transaminase in Danes aged 30 to 50 years.

https://arctichealth.org/en/permalink/ahliterature10558
Source
Dan Med Bull. 1999 Nov;46(5):429-31
Publication Type
Article
Date
Nov-1999
Author
A M Thulstrup
B. Nørgård
F H Steffensen
H. Vilstrup
H T Sørensen
T. Lauritzen
Author Affiliation
Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus. amt@soci.au.dk
Source
Dan Med Bull. 1999 Nov;46(5):429-31
Date
Nov-1999
Language
English
Publication Type
Article
Keywords
Adult
Alanine Transaminase - blood
Body constitution
Body mass index
Comparative Study
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Obesity - enzymology - epidemiology
Predictive value of tests
Prevalence
Regression Analysis
Research Support, Non-U.S. Gov't
Sex Characteristics
Abstract
INTRODUCTION: We examined whether waist circumference and waist-to-hip circumference ratio were a better predictor for elevated alanine transaminase level than body mass index. METHODOLOGY: In a cross-sectional survey we examined body mass index, waist circumference, waist-to-hip ratio, alcohol consumption, and alanine transaminase level in a random sample of 903 men and women aged 30 to 50 years from The Ebeltoft Health Promotion Project in Denmark. RESULTS: Body mass index, waist circumference and waist-to-hip ratio explained an approximate 12% variation in alanine transaminase in men and 4% in women, whereas waist-to-hip circumference ratio explained a 2% variation in women. The risk of elevated alanine transaminase level in men, calculated as odds ratio, with a body mass index (kg/m2) above 30, or a waist circumference above 102 cm, or a waist-to-hip circumference ratio above 0.9 was 9.3 (95% confidence interval [CI], 3.6-24.1), 5.6 (95% CI, 2.5-12.5) and 2.7 (95% CI, 1.3-5.3) respectively, but there was no elevated risk among women. CONCLUSIONS: Waist circumference and body mass index were both predictors in men. Waist-to-hip ratio was also a predictor in men, but not as strong a predictor as waist circumference and body mass index. No association was found in women. This difference is probably explained by differences in the accumulation of intra-abdominal adipose tissue among men and women with the same degree of obesity.
PubMed ID
10605624 View in PubMed
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7 records – page 1 of 1.