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Cord blood IgE. I. IgE screening in 2814 newborn children.

https://arctichealth.org/en/permalink/ahliterature36633
Source
Allergy. 1992 Aug;47(4 Pt 2):391-6
Publication Type
Article
Date
Aug-1992
Author
L G Hansen
A. Høst
S. Halken
A. Holmskov
S. Husby
L B Lassen
K. Storm
O. Osterballe
Author Affiliation
Department of Pediatrics, Odense University Hospital, Denmark.
Source
Allergy. 1992 Aug;47(4 Pt 2):391-6
Date
Aug-1992
Language
English
Publication Type
Article
Keywords
Cohort Studies
Denmark - epidemiology
Female
Fetal Blood - immunology
Humans
Hypersensitivity, Immediate - diagnosis - epidemiology
Immunoglobulin A - blood
Immunoglobulin E - blood
Male
Pregnancy
Reproducibility of Results
Research Support, Non-U.S. Gov't
Seasons
Sensitivity and specificity
Abstract
Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). 48.6% of the sera contained less IgE than the detection limit 0.1 kU/l. Cord blood IgE values greater than or equal to 0.5 kU/l were regarded as elevated. 13.2% of the sera contained at least 0.5 kU/l of IgE, with a significant preponderance in boys. Geometric mean cord blood IgE was 0.13 kU/l and 0.12 kU/l, respectively. Geometric mean cord blood IgE was significantly higher in boys. A significant seasonal variation with lowest IgE values in the autumn was found. No correlation between cord blood IgE and birth weight or gestational age was demonstrated. Only few newborns had cord blood IgA values greater than 0.014 g/l, calculated as geometric mean cord blood IgA + 2 SD among children with no detectable cord blood IgE, indicating infrequent contamination with maternal blood.
PubMed ID
1456410 View in PubMed
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Cord blood IgE. III. Prediction of IgE high-response and allergy. A follow-up at the age of 18 months.

https://arctichealth.org/en/permalink/ahliterature59594
Source
Allergy. 1992 Aug;47(4 Pt 2):404-10
Publication Type
Article
Date
Aug-1992
Author
L G Hansen
A. Høst
S. Halken
A. Holmskov
S. Husby
L B Lassen
K. Storm
O. Osterballe
Author Affiliation
Department of Pediatrics, Viborg Hospital, Denmark.
Source
Allergy. 1992 Aug;47(4 Pt 2):404-10
Date
Aug-1992
Language
English
Publication Type
Article
Keywords
Animals
Cohort Studies
Denmark
Female
Fetal Blood - immunology
Follow-Up Studies
Humans
Hypersensitivity, Immediate - diagnosis - immunology
Immunoglobulin E - blood
Infant
Male
Milk - immunology
Predictive value of tests
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Abstract
Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total group of 762 infants were clinically evaluated at 18 months of age, and in 688 of these we evaluated total and specific IgE. A diagnosis of definite atopy, probable atopy or no atopy was established. In the present study we defined allergic disease as atopic disease combined with elevated total IgE. We found a statistically significant correlation between cord blood IgE and IgE at 18 months of age. Significantly more infants with elevated cord blood IgE had developed allergic disease at 18 months. A cut-off value of 0.3 kU/l for cord blood IgE was superior to the originally suggested 0.5 kU/l. Significantly more infants with elevated cord blood IgE had developed specific IgE antibodies at 18 months. The most frequent specific IgE antibody was towards cow's milk. Specific IgE antibodies were very rarely found when total IgE was not elevated. A total IgE at the age of 18 months greater than 26 kU/l could be regarded as elevated. With regard to allergic disease the positive predictive values of cord blood IgE greater than or equal to 0.3 kU/l in the 2 series were 21% and the corresponding sensitivities 67% and 46%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
1456412 View in PubMed
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Cord blood IgE. II. Prediction of atopic disease. A follow-up at the age of 18 months.

https://arctichealth.org/en/permalink/ahliterature59595
Source
Allergy. 1992 Aug;47(4 Pt 2):397-403
Publication Type
Article
Date
Aug-1992
Author
L G Hansen
A. Høst
S. Halken
A. Holmskov
S. Husby
L B Lassen
K. Storm
O. Osterballe
Author Affiliation
Department of Pediatrics, Viborg Hospital, Denmark.
Source
Allergy. 1992 Aug;47(4 Pt 2):397-403
Date
Aug-1992
Language
English
Publication Type
Article
Keywords
Cohort Studies
Denmark
Female
Fetal Blood - immunology
Follow-Up Studies
Humans
Hypersensitivity, Immediate - diagnosis - genetics - immunology
Immunoglobulin E - blood
Infant
Male
Predictive value of tests
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Abstract
Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total of 762 infants were clinically evaluated at 18 months of age. A diagnosis of definite atopy, probable atopy or no atopy, including both IgE and non-IgE mediated disease was established. Applying different cord blood IgE cut-off values (0.3, 0.5, 0.8, 1.1) we did not find an excess of atopic infants among those with elevated cord blood IgE irrespective of the chosen cut-off value. Atopic predisposition or family history of atopic disease was defined as at least one parent or older sibling with atopic disease. Significantly more infants with a family history developed atopy at 18 months. In the 2 series the positive predictive values of cord blood IgE greater than or equal to 0.5 were 43% and 46% and the sensitivities were 17% and 15%. The predictive values of having a family history were 48% and 44% and the sensitivities were 55% and 58%.
PubMed ID
1456411 View in PubMed
Less detail

Food allergy and food sensitization in early childhood: results from the DARC cohort.

https://arctichealth.org/en/permalink/ahliterature152621
Source
Allergy. 2009 Jul;64(7):1023-9
Publication Type
Article
Date
Jul-2009
Author
E. Eller
H F Kjaer
A. Høst
K E Andersen
C. Bindslev-Jensen
Author Affiliation
Department of Dermatology, Odense University Hospital, Odense, Denmark.
Source
Allergy. 2009 Jul;64(7):1023-9
Date
Jul-2009
Language
English
Publication Type
Article
Keywords
Allergens - immunology
Child, Preschool
Cohort Studies
Denmark - epidemiology
Dermatitis, Atopic - epidemiology - immunology
Female
Follow-Up Studies
Food Hypersensitivity - epidemiology - immunology
Humans
Immunoglobulin E - blood
Infant
Infant, Newborn
Male
Prospective Studies
Skin Tests
Abstract
The prevalence of food hypersensitivity (FHS) and the relationship with atopic dermatitis (AD) is controversial. The aim of this study was to determine the development of FHS and to correlate this with AD in relation to sensitization and symptoms.
This study combines new data from birth to 18 months of age with previous published results from 3 and 6 years. The Danish Allergy Research Centre cohort, including 562 children, is a unique, population-based, prospective birth cohort, with clinical examinations at all follow-ups. All children were examined for the development of AD using Hanifin-Rajka criteria and for FHS using interviews, skin prick test (SPT), specific immunoglobulin E (IgE), and food challenge according to EAACI guidelines.
Twenty children were confirmed with FHS to milk, egg, and peanut. FHS peaked at 18 months (3.6%) and then decreased to 1.2% at 72 months of age. No new cases were found after 3 years. Self-reporting could only be confirmed in 31% of cases. Among the 122 children with AD, 18 had FHS (14.8%). FHS was IgE-mediated in 95% of the cases but 16 of 20 children were additionally sensitized to other foods which they tolerated. Children with AD were neither more IgE-sensitized nor had higher levels of IgE when compared with healthy children but they were more persistently sensitized.
Sensitization to foods in young children without food allergy seems to be a normal phenomenon. The discrepancy between sensitization, self-reported food-related symptoms and confirmed FHS illustrates the need to perform standardized oral challenges in order to confirm the diagnosis of FHS.
PubMed ID
19220211 View in PubMed
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Prediction of allergy from family history and cord blood IgE levels. A follow-up at the age of 5 years. Cord blood IgE. IV.

https://arctichealth.org/en/permalink/ahliterature16023
Source
Pediatr Allergy Immunol. 1993 Feb;4(1):34-40
Publication Type
Article
Date
Feb-1993
Author
L G Hansen
S. Halken
A. Høst
K. Møller
O. Osterballe
Author Affiliation
Department of Pediatrics, Viborg Hospital, Denmark.
Source
Pediatr Allergy Immunol. 1993 Feb;4(1):34-40
Date
Feb-1993
Language
English
Publication Type
Article
Keywords
Age Factors
Child, Preschool
Female
Fetal Blood - immunology
Follow-Up Studies
Humans
Hypersensitivity - genetics - immunology
Immunoglobulin E - blood
Infant
Infant, Newborn
Male
Research Support, Non-U.S. Gov't
Abstract
Screening of total IgE in 1189 cord blood samples was conducted by Phadebas IgE PRIST in a one-year birth cohort 1983-1984 in Viborg, Denmark. 113 children with cord blood IgE levels > or = 0.5 kU/l and 138 children chosen at random among those with cord blood IgE levels 63 kU/l (geometric mean + 1 SD) at the age of 5 years can be regarded as being an elevated level. A cord blood IgE level > or = 0.3 kU/l in combination with atopic predisposition was predictive of allergic disease, especially allergic bronchial asthma. With regard to allergic disease, the positive predictive value was 26%, the sensitivity 33% and the rate ratio for development of allergic disease 4.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
8348254 View in PubMed
Less detail