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Increased incidence of autoimmune disorders as a late complication in children with early onset dermatitis and/or milk allergy.

https://arctichealth.org/en/permalink/ahliterature30356
Source
J Autoimmun. 2004 Jun;22(4):341-4
Publication Type
Article
Date
Jun-2004
Author
Jorma Kokkonen
Aila Niinimäki
Author Affiliation
Department of Pediatrics, Oulu University Hospital, P.O. Box 23, Fin-90029 OYS, Oulu, Finland. jorma.kokkonen@ppshp.fi
Source
J Autoimmun. 2004 Jun;22(4):341-4
Date
Jun-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Autoimmune Diseases - etiology - immunology
Case-Control Studies
Cohort Studies
Dermatitis, Atopic - complications - immunology
Female
Gastrointestinal Diseases - etiology - immunology
Humans
Infant
Male
Milk Hypersensitivity - complications - immunology
Questionnaires
Research Support, Non-U.S. Gov't
Retrospective Studies
Risk factors
Abstract
Subjects with atopic dermatitis and autoimmune disorders share some similar immune response disorders. The aim of this study was to see whether subjects with early onset atopic dermatitis run a risk of eventually developing autoimmune diseases. The results of a questionnaire of 145 adolescents (70 f, 75 m, mean age 18.2 years, range 16-23 years) was compared with those of a group of 262 controls (112 f, 150 m, mean age 17.5 years, range 16-21 years), 164 of whom reported no atopic symptoms and were treated as a separate group for statistical analysis. As compared with the non-atopic controls, the study group subjects showed a significantly increased incidence of autoimmune disorders (9% vs. 1%), the relative risk ratio of a subject with infantile onset atopic eczema getting a gastrointestinal (GI) immune-mediated disease being 2.4 (CI(95)2.1-2.8) and of getting some other autoimmune disorder 3.1 (CI(95)2.8-9.7). The positive skin prick tests showed a negative association with the manifestation of a GI or other autoimmune disorder. The subjects with infantile dermatitis also reported recurrent abdominal pains (23% vs. 15%), and milk-induced gastrointestinal symptoms (19% vs. 10%) significantly more even as young adults than the controls. Our study showed that infantile atopy increases a predisposition to autoimmune disorders, suggesting that these two entities might have a common immunological determinant. While a high incidence of chronic GI complaints among the study subjects suggests the ongoing activity of local immune responses. However, more detailed prospective studies are needed to confirm these observations.
PubMed ID
15120758 View in PubMed
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Specific IgE positivity against inhalant allergens and development of autoimmune disease.

https://arctichealth.org/en/permalink/ahliterature271586
Source
Autoimmunity. 2015;48(5):282-8
Publication Type
Article
Date
2015
Author
Tea Skaaby
Lise Lotte Nystrup Husemoen
Betina Heinsbæk Thuesen
Runa Vavia Fenger
Allan Linneberg
Source
Autoimmunity. 2015;48(5):282-8
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Allergens - immunology
Antibody Specificity - immunology
Autoimmune Diseases - epidemiology - etiology
Denmark - epidemiology
Female
Humans
Hypersensitivity - complications - immunology
Immunoglobulin E - immunology
Male
Middle Aged
Population Surveillance
Proportional Hazards Models
Registries
Risk factors
Surveys and Questionnaires
Young Adult
Abstract
Allergic and autoimmune diseases have been suggested to be inversely associated. We investigated the association between atopy and development of any and specific types of autoimmune disease.
We included a total of 14,849 individuals from five population-based studies with measurements of atopy defined as specific IgE positivity against inhalant allergens. We followed the participants by linkage to the Danish National Patient Register (median follow-up time 11.2 years). Hazard ratio (HR) and 95% confidence interval (CI) of autoimmune disease were estimated by Cox regression.
The risk for atopics versus non-atopics was: for any autoimmune disease (HR?=?0.99, 95% CI: 0.83, 1.18), thyrotoxicosis (HR?=?0.69, 95% CI: 0.34, 1.37), type 1 diabetes (HR?=?1.16, 95% CI: 0.84, 1.60), multiple sclerosis (HR?=?1.97, 95% CI: 0.95, 4.11), iridocyclitis (HR?=?0.82, 95% CI: 0.38, 1.74), Crohn's disease (HR?=?1.03, 95% CI: 0.47, 2.25), ulcerative colitis (HR?=?0.93, 95% CI: 0.52, 1.69), psoriasis vulgaris (HR?=?1.50, 95% CI: 0.86, 2.62), seropositive rheumatoid arthritis (HR?=?0.74, 95% CI: 0.48, 1.14) and polymyalgia rheumatica (HR?=?0.79, 95% CI: 0.44, 1.44).
We found no statistically significant associations between atopy and autoimmune disease, but we cannot exclude relatively small to moderate effects - protective or promotive - of atopy on autoimmune disease.
PubMed ID
25600125 View in PubMed
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