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Maternal intake of fatty acids during pregnancy and allergies in the offspring.

https://arctichealth.org/en/permalink/ahliterature129802
Source
Br J Nutr. 2012 Aug;108(4):720-32
Publication Type
Article
Date
Aug-2012
Author
Bright I Nwaru
Maijaliisa Erkkola
Mirka Lumia
Carina Kronberg-Kippilä
Suvi Ahonen
Minna Kaila
Jorma Ilonen
Olli Simell
Mikael Knip
Riitta Veijola
Suvi M Virtanen
Author Affiliation
School of Health Sciences, University of Tampere, Tampere, Finland. bright.nwaru@uta.fi
Source
Br J Nutr. 2012 Aug;108(4):720-32
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Asthma - epidemiology - etiology - physiopathology - prevention & control
Butter - adverse effects
Child, Preschool
Cohort Studies
Dermatitis, Atopic - epidemiology - etiology - physiopathology - prevention & control
Dietary Fats - administration & dosage - adverse effects - therapeutic use
Fatty Acids, Omega-6 - administration & dosage - adverse effects
Female
Finland - epidemiology
Follow-Up Studies
Humans
Hypersensitivity - epidemiology - etiology - physiopathology - prevention & control
Incidence
Male
Maternal Nutritional Physiological Phenomena
Pregnancy
Prevalence
Proportional Hazards Models
Prospective Studies
Rhinitis, Allergic, Perennial - epidemiology - etiology - physiopathology - prevention & control
Rhinitis, Allergic, Seasonal - epidemiology - etiology - physiopathology - prevention & control
alpha-Linolenic Acid - administration & dosage - therapeutic use
Abstract
Fatty acids (FA) are known to have a number of immunological effects and, accordingly, may play a role in the development of allergic diseases. We investigated the effect of maternal intake of FA during pregnancy on the risk of allergic rhinitis, wheeze and atopic eczema in children aged 5 years. The present study analysed data from the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with a 5-year follow-up. Complete information on maternal diet (assessed by a validated FFQ) and International Study of Asthma and Allergies in Childhood-based allergic outcomes was available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. After adjusting for potential confounding variables, high maternal consumption of butter and butter spreads (hazard ratio (HR) 1.33; 95 % CI 1.03, 1.71) and higher ratio of n-6:n-3 FA (HR 1.37; 95 % CI 1.07, 1.77) during pregnancy were associated with an increased risk of allergic rhinitis in the offspring by 5 years of age. High maternal intakes of total PUFA (HR 0.71; 95 % CI 0.52, 0.96) and a-linolenic FA (HR 0.73; 95 % CI 0.54, 0.98) were associated with a decreased risk of allergic rhinitis. However, these results lost their significance after adjustment for multiple comparisons. Overall, our data suggest that maternal consumption of butter, the ratio of n-6:n-3 FA and intake of PUFA and a-linolenic FA during pregnancy may be potential determinants of allergic rhinitis in the offspring.
PubMed ID
22067943 View in PubMed
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