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2431 records – page 1 of 244.

1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships.

https://arctichealth.org/en/permalink/ahliterature166384
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Publication Type
Article
Date
Mar-20-2007
Author
Hong Cheng
Nalini Sathiakumar
John Graff
Robert Matthews
Elizabeth Delzell
Author Affiliation
University of Alabama at Birmingham, Ryals School of Public Health, Department of Epidemiology, Birmingham, AL, USA. hcheng@ms.soph.uab.edu
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Date
Mar-20-2007
Language
English
Publication Type
Article
Keywords
Butadienes - adverse effects
Canada - epidemiology
Carcinogens - chemical synthesis - chemistry - toxicity
Chemical Industry - manpower - statistics & numerical data
Confidence Intervals
Dimethyldithiocarbamate - adverse effects
Humans
Leukemia, Lymphoid - chemically induced - epidemiology
Leukemia, Myeloid - chemically induced - epidemiology
Likelihood Functions
Male
Middle Aged
Occupational Exposure - statistics & numerical data
Proportional Hazards Models
Rubber - adverse effects - chemical synthesis - chemistry
United States - epidemiology
Abstract
Previous research updated the mortality experience of North American synthetic rubber industry workers during the period 1944-1998, determined if leukemia and other cancers were associated with several employment factors and carried out Poisson regression analysis to examine exposure-response associations between estimated exposure to 1,3-butadiene (BD) or other chemicals and cancer. The present study used Cox regression procedures to examine further the exposure-response relationship between several unlagged and lagged, continuous, time-dependent BD exposure indices (BD parts per million (ppm)-years, the total number of exposures to BD concentrations >100 ppm ("peaks") and average intensity of BD) and leukemia, lymphoid neoplasms and myeloid neoplasms. All three BD exposure indices were associated positively with leukemia. Using continuous, untransformed BD ppm-years the regression coefficient (beta) from an analysis that controlled only for age was 2.9 x 10(-4) (p
PubMed ID
17123495 View in PubMed
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1,3-Butadiene: exposure estimation, hazard characterization, and exposure-response analysis.

https://arctichealth.org/en/permalink/ahliterature186649
Source
J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):55-83
Publication Type
Article
Author
K. Hughes
M E Meek
M. Walker
R. Beauchamp
Author Affiliation
Existing Substances Division, Environmental Health Directorate, Health Canada, Environmental Health Centre, Tunney's Pasture PL0802B1, Ottawa, Ontario, Canada K1A 0L2.
Source
J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):55-83
Language
English
Publication Type
Article
Keywords
Animals
Butadienes - metabolism - toxicity
Canada - epidemiology
Carcinogens, Environmental - toxicity
Environmental Exposure
Hazardous Substances - toxicity
Humans
Mutagens - toxicity
Neoplasms - chemically induced - epidemiology
Occupational Diseases - chemically induced - epidemiology
Risk assessment
Abstract
1,3-Butadiene has been assessed as a Priority Substance under the Canadian Environmental Protection Act. The general population in Canada is exposed to 1,3-butadiene primarily through ambient air. Inhaled 1,3-butadiene is carcinogenic in both mice and rats, inducing tumors at multiple sites at all concentrations tested in all identified studies. In addition, 1,3-butadiene is genotoxic in both somatic and germ cells of rodents. It also induces adverse effects in the reproductive organs of female mice at relatively low concentrations. The greater sensitivity in mice than in rats to induction of these effects by 1,3-butadiene is likely related to species differences in metabolism to active epoxide metabolites. Exposure to 1,3-butadiene in the occupational environment has been associated with the induction of leukemia; there is also some limited evidence that 1,3-butadiene is genotoxic in exposed workers. Therefore, in view of the weight of evidence of available epidemiological and toxicological data, 1,3-butadiene is considered highly likely to be carcinogenic, and likely to be genotoxic, in humans. Estimates of the potency of butadiene to induce cancer have been derived on the basis of both epidemiological investigation and bioassays in mice and rats. Potencies to induce ovarian effects have been estimated on the basis of studies in mice. Uncertainties have been delineated, and, while there are clear species differences in metabolism, estimates of potency to induce effects are considered justifiably conservative in view of the likely variability in metabolism across the population related to genetic polymorphism for enzymes for the critical metabolic pathway.
PubMed ID
12587254 View in PubMed
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2-hydroxypropyl-Ã?-cyclodextrin in eye drops: Evaluation in human patients

https://arctichealth.org/en/permalink/ahliterature102117
Source
Pages 55-57 in G. Pétursdóttir et al., eds. Circumpolar Health 93. Proceedings of the 9th International Congress on Circumpolar Health, Reykjavík, Iceland, June 20-25, 1993. Arctic Medical Research. 1994;53(Suppl.2)
Publication Type
Article
Date
1994
. This allows the use of hydrophobic drugs and lipids in aqueous eye drops containing cyclodextrin. This study examines the possible toxicity of an eye drop preparation that contains 2-hydroxypropyl-8-cyclodextrin, and its possible efficacy as a lubricant in patients with dry eyes. Artificial tear
  1 document  
Author
Thórisdóttir, S
Stefánsson, E
Loftsson, Th.
Guðmundsson, �G
Friðriksdóttir, H
Guðmundsson, �,
Sigthórsson, Th
Thorisdottir, S
Stefansson, E
Guomundsson, O.G.
Frioriksdottir, H
Guomundsson, O
Sigthorsson, Th
Author Affiliation
Department of Ophthalmology, University of Iceland, Reykjavik
Department of Pharmacy, University of Iceland, Reykjavik
Landakot Hospital Dept. of Ophthalmology, Reykjavik, Iceland
Lyfjaverslun ríkisins, Reykjavik, Iceland
Source
Pages 55-57 in G. Pétursdóttir et al., eds. Circumpolar Health 93. Proceedings of the 9th International Congress on Circumpolar Health, Reykjavík, Iceland, June 20-25, 1993. Arctic Medical Research. 1994;53(Suppl.2)
Date
1994
Language
English
Publication Type
Article
Digital File Format
Text - PDF
Keywords
2-hydroxypropyl-Ã?-cyclodextrin
aqueous eye drops
artificial tear solution
cyclodextrin
dry eyes
hydrophobic drugs
Lipids
ophthalmic formulation
Solubility
toxicity
Abstract
Cyclodextrins facilitate the solubility of hydrophobic compounds in aqueous solutions. This allows the use of hydrophobic drugs and lipids in aqueous eye drops containing cyclodextrin. This study examines the possible toxicity of an eye drop preparation that contains 2-hydroxypropyl-Ã?-cyclodextrin and its possible efficacy as a lubricant in patients with dry eyes. Artificial tear solution that contains a lipid (cholesterol), an oligosaccharide (2-hydroxypropyl-Ã?-cyclodextrin) and saline was produced to mimic the natural tear film of the eye. The toxicity and usefulness of this drug was studied in rabbits and humans. The results demonstrate that the cyclodextrin-cholesterol artificial tear solution is well tolerated by the rabbit and human eye and is not toxic. It had therapeutic value in people with mild dryness of eyes, while those with severe dryness found no beneficial effect.
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2nd Norwegian Environmental Toxicology Symposium: joining forces for an integrated search for environmental solutions.

https://arctichealth.org/en/permalink/ahliterature90204
Source
J Toxicol Environ Health A. 2009;72(3-4):111
Publication Type
Article
Date
2009

6TH NORWEGIAN ENVIRONMENTAL TOXICOLOGY SYMPOSIUM: Assessing and solving environmental challenges in a multiple stressor world.

https://arctichealth.org/en/permalink/ahliterature296704
Source
J Toxicol Environ Health A. 2017; 80(16-18):805-806
Publication Type
Introductory Journal Article
Date
2017
Author
Knut Erik Tollefsen
Sam Kacew
Author Affiliation
a Section for Ecotoxicology and Risk Assessment, Norwegian Institute for Water Research (NIVA) , Oslo , Norway.
Source
J Toxicol Environ Health A. 2017; 80(16-18):805-806
Date
2017
Language
English
Publication Type
Introductory Journal Article
Keywords
Ecotoxicology
Environmental Exposure
Environmental Monitoring - methods
Environmental Pollutants - toxicity
Norway
Risk Assessment - methods
PubMed ID
28829685 View in PubMed
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[28-year follow up of smoking habits of Swedish physicians. Reduced number of smokers but increased number of snuff-users]

https://arctichealth.org/en/permalink/ahliterature67649
Source
Lakartidningen. 1996 Nov 27;93(48):4437-40, 4443-4
Publication Type
Article
Date
Nov-27-1996

238Pu: accumulation, tissue distribution, and excretion in Mayak workers after exposure to plutonium aerosols.

https://arctichealth.org/en/permalink/ahliterature126152
Source
Health Phys. 2012 Mar;102(3):243-50
Publication Type
Article
Date
Mar-2012
Author
Klara G Suslova
Alexandra B Sokolova
Viktor V Khokhryakov
Scott C Miller
Author Affiliation
Southern Urals Biophysics Institute (SUBI), Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia. suslova@subi.su
Source
Health Phys. 2012 Mar;102(3):243-50
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Aerosols
Bone and Bones - metabolism - radiation effects
Health Physics
Humans
Liver - metabolism - radiation effects
Lung - metabolism - radiation effects
Occupational Exposure
Plutonium - administration & dosage - pharmacokinetics - toxicity - urine
Russia
Solubility
Tissue Distribution
Abstract
The alpha spectrometry measurements of specific activity of 238Pu and 239Pu in urine from bioassay examinations of 1,013 workers employed at the radiochemical and plutonium production facilities of the Mayak Production Association and in autopsy specimens of lung, liver, and skeleton from 85 former nuclear workers who died between 1974-2009, are summarized.The accumulation fraction of 238Pu in the body and excreta has not changed with time in workers involved in production of weapons-grade plutonium production (e.g., the plutonium production facility and the former radiochemical facility). The accumulation fraction of 238Pu in individuals exposed to plutonium isotopes at the newer Spent Nuclear Fuel Reprocessing Plant ranged from 0.13% up to 27.5% based on the autopsy data. No statistically significant differences between 238Pu and 239Pu in distribution by the main organs of plutonium deposition were found in the Mayak workers. Based on the bioassay data,the fraction of 238Pu activity in urine is on average 38-69% of the total activity of 238Pu and 239Pu, which correlates with the isotopic composition in workplace air sampled at the Spent Nuclear Fuel Reprocessing Plant. In view of the higher specific activity of 238Pu, the contribution of 238Pu to the total internal dose, particularly in the skeleton and liver, might be expected to continue to increase, and continued surveillance is recommended.
PubMed ID
22420016 View in PubMed
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700,000 complaints against high tobacco taxes fail to sway government or MDs.

https://arctichealth.org/en/permalink/ahliterature225904
Source
CMAJ. 1991 Aug 1;145(3):245
Publication Type
Article
Date
Aug-1-1991
Author
P. Sullivan
Source
CMAJ. 1991 Aug 1;145(3):245
Date
Aug-1-1991
Language
English
Publication Type
Article
Keywords
Canada
Humans
Plants, Toxic
Smoking - prevention & control
Taxes
Tobacco
PubMed ID
2070317 View in PubMed
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The ABCB1, rs9282564, AG and TT genotypes and the COMT, rs4680, AA genotype are less frequent in deceased patients with opioid addiction than in living patients with opioid addiction

https://arctichealth.org/en/permalink/ahliterature280048
Source
Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):381-8
Publication Type
Article
Date
Oct-2016
Author
Christoffersen DJ
Damkier P
Feddersen S
Möller S
Thomsen JL
Brasch-Andersen C
Brøsen K
Source
Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):381-8
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Catechol O-Methyltransferase - genetics - metabolism
Cohort Studies
Death, Sudden - etiology
Denmark
Female
Genetic Association Studies
Heterozygote
Homozygote
Humans
Male
Methadone - blood - toxicity
Middle Aged
Morphine - blood - toxicity
Morphine Dependence - genetics - metabolism - mortality - physiopathology
Narcotics - blood - toxicity
P-Glycoproteins - genetics - metabolism
Polymorphism, Single Nucleotide
Young Adult
Abstract
Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated with this, we examined the frequencies of 29 SNPs located in candidate genes related to opioid pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT, KCNJ6 and SCN9A in 274 deceased patients with OA (DOA), 309 living patients with OA (LOA) and in 394 healthy volunteers (HV). The main hypothesis of the study was that subjects homozygous for the variant 3435T in ABCB1 (rs1045642) occur more frequently in DOA than in LOA and HV because morphine and methadone more readily cross the blood barrier in these subjects due to a lower efflux transporter activity of the ABCB1 (p-glycoprotein) transporter. Our results did not support this hypothesis, because no statistically significant difference (p = 0.506) in the frequency of the TT genotype of rs1045642 was observed between the DOA, LOA and HV cohorts. However, for another ABCB1 variant, rs9282564, we found that the frequencies of the AG and TT genotypes were 13, 21 and 25% in DOA, LOA and HV, respectively, and after correcting for age, sex and multiple testing, the differences between DOA and LOA were statistically significantly different (p = 0.027). The COMT rs4680 AA genotype frequencies were 25%, 35% and 31% in DOA, LOA and HV, respectively, and the difference between DOA and LOA was also statistically significant (p = 0.0028). In conclusion, this study generated two hypotheses suggesting possible associations of a reduced risk of death and carrying, respectively, the ABCB1 rs9282564 AG and TT genotypes and the COMT rs4680 AA genotype among patients with OA. These findings should be confirmed in independent cohorts, and if a causal relationship between these variants and fatal poisoning in OA is confirmed, then it may be possible at least in theory to personalize prevention of sudden death in this patient group.
PubMed ID
27061230 View in PubMed
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2431 records – page 1 of 244.