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AHSG gene variant is associated with leanness among Swedish men.

https://arctichealth.org/en/permalink/ahliterature175447
Source
Hum Genet. 2005 Jun;117(1):54-60
Publication Type
Article
Date
Jun-2005
Author
Catharina Lavebratt
Sofia Wahlqvist
Louise Nordfors
Johan Hoffstedt
Peter Arner
Author Affiliation
Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital L8:00, Stockholm, Sweden. catharina.lavebratt@cmm.ki.se
Source
Hum Genet. 2005 Jun;117(1):54-60
Date
Jun-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Animals
Blood Proteins - genetics
Body mass index
Case-Control Studies
Genotype
Humans
Linkage Disequilibrium
Male
Mice
Mice, Knockout
Middle Aged
Obesity - genetics
Odds Ratio
Risk factors
Sweden
alpha-2-HS-Glycoprotein
Abstract
Alpha(2) Heremans-Schmid glycoprotein (AHSG) is a plasma protein inhibiting the activity of the insulin receptor tyrosine kinase. Ahsg knock-out mice have increased insulin sensitivity and are resistant to diet-induced obesity. We hypothesized that functional variants of the AHSG gene segregating in the human population would reflect variation in body mass index (BMI). We genotyped 356 overweight or obese (BMI: 37.2 [25.0-66.5] kg/m(2)) and 148 lean (BMI: 23.7 [23.4-24.9] kg/m(2)) otherwise healthy Swedish men for three non-synonymous single-nucleotide polymorphisms (SNPs) within exon 6 (rs4917) and exon 7 (rs4918 and Arg299Cys) and one SNP in intron 1 (rs2593813) of the AHSG gene. The G/G genotype for rs2593813 was more common among lean than among obese and overweight individuals (odds ratio = 2.01, P = 0.009), whereas rs2593813 was in strong linkage disequilibrium (
D'
> or = 0.97) with rs4917 and rs4918. Homozygosity for the rs2593813:G-rs4917:Met-rs4918:Ser haplotype conferred an increased risk for leanness (odds ratio=1.90, P = 0.027). rs4917:Met and rs4918:Ser have previously been associated with lower AHSG protein level. A common variant of AHSG, previously associated with a lower AHSG protein level, is thus more common among lean than obese and overweight men, supporting the results from Ahsg knock-out mice, namely, that AHSG modulates body mass.
PubMed ID
15806395 View in PubMed
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Climate-dependent genetic variation of alpha-2HS-glycoprotein.

https://arctichealth.org/en/permalink/ahliterature205590
Source
Hum Biol. 1998 Jun;70(3):463-75
Publication Type
Article
Date
Jun-1998
Author
V A Spitsyn
O I Kravchuk
S D Nurbaev
D. Krause
W. Kuchheuser
Author Affiliation
Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia.
Source
Hum Biol. 1998 Jun;70(3):463-75
Date
Jun-1998
Language
English
Publication Type
Article
Keywords
Alleles
Blood Proteins - genetics
Climate
Computer simulation
Ethnic Groups - genetics
European Continental Ancestry Group - genetics
Female
Gene Frequency
Genetic Variation
Humans
Male
Metalloendopeptidases - genetics
Models, Genetic
Phenotype
Random Allocation
Russia
Sampling Studies
World Health
alpha-2-HS-Glycoprotein
Abstract
We studied the possible effects of climatic factors on the world distribution of alleles determining alpha 2-HS-glycoprotein (AHSG) phenotypes in human populations. New data on AHSG polymorphism in certain ethnic groups of Russia are presented. All available data on the distribution of AHSG gene frequencies in the world (number of populations n = 51) were used to analyze possible correlations between AHSG*2 allele frequencies and seven climatic-geographic parameters. A strong positive correlation was found between AHSG*2 allele frequency and geographic latitude of territories inhabited by the study populations (r = 0.814). The dependence of the AHSG*2 allele distribution in the world on the intensity of ultraviolet radiation (400-315 nm) was estimated at r = -0.826. Such climatic characteristics as the total amount of insolation and the average annual temperature proved to make equal contributions to variation in AHSG*2 allele frequency (r = -0.683 and -0.658, respectively). A computer cartographic model of the AHSG*2 allele distribution in the Old World populations of the Northern Hemisphere was constructed.
PubMed ID
9599939 View in PubMed
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