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The 1 alpha-hydroxylase locus is not linked to calcium stone formation or calciuric phenotypes in French-Canadian families.

https://arctichealth.org/en/permalink/ahliterature206213
Source
J Am Soc Nephrol. 1998 Mar;9(3):425-32
Publication Type
Article
Date
Mar-1998
Author
P. Scott
D. Ouimet
Y. Proulx
M L Trouvé
G. Guay
B. Gagnon
L. Valiquette
A. Bonnardeaux
Author Affiliation
Service de Néphrologie, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Source
J Am Soc Nephrol. 1998 Mar;9(3):425-32
Date
Mar-1998
Language
English
Publication Type
Article
Keywords
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics - metabolism
Adult
Calcium - urine
Canada
European Continental Ancestry Group - genetics
Family Health
Female
France - ethnology
Genetic Linkage
Genetic Markers - genetics
Humans
Kidney Calculi - enzymology - genetics
Male
Middle Aged
Nuclear Family
Pedigree
Phenotype
Vitamin D - blood
Abstract
Calcium urolithiasis is often associated with increased intestinal absorption and urine excretion of calcium, and has been suggested to result from increased vitamin D production. The role of the enzyme 1 alpha-hydroxylase, the rate-limiting step in active vitamin D production, was evaluated in 36 families, including 28 sibships with at least a pair of affected sibs, using qualitative and quantitative trait linkage analyses. Sibs with a verified calcium urolithiasis passage (n = 117) had higher 24-h calciuria (P = 0.03), oxaluria (P = 0.02), fasting and postcalcium loading urine calcium/creatinine (Ca/cr) ratios (P = 0.008 and P = 0.002, respectively), and serum 1,25(OH)2 vitamin D levels (P = 0.02) compared with nonstone-forming sibs (n = 120). Markers from a 9-centiMorgan interval encompassing the VDD1 locus on chromosome 12q13-14 (putative 1 alpha-hydroxylase) were analyzed in 28 sibships (146 sib pairs) of single and recurrent stone formers and in 14 sibships (65 sib pairs) with recurrent-only (> or = 3 episodes) stone-forming sibs. Two-point and multipoint analyses did not reveal excess in alleles shared among affected sibs at the VDD1 locus. Linkage of stone formation to the VDD1 locus could be excluded, respectively, with a lambda d of 2.0 (single and recurrent stone formers) and 3.25 (recurrent stone formers). Quantitative trait analyses revealed no evidence for linkage to 24-h calciuria and oxaluria, serum 1,25(OH)2 vitamin D levels, and Ca/cr ratios. This study shows absence of linkage of the putative 1 alpha-hydroxylase locus to calcium stone formation or to quantitative traits associated with idiopathic hypercalciuria. In addition, there is coaggregation of calciuric and oxaluric phenotypes with stone formation.
PubMed ID
9513904 View in PubMed
Less detail

25-Hydroxycholecaliferol and fractures of the proximal.

https://arctichealth.org/en/permalink/ahliterature252013
Source
Lancet. 1975 Aug 16;2(7929):300-2
Publication Type
Article
Date
Aug-16-1975
Author
B. Lund
O H Sorensen
A B Christensen
Source
Lancet. 1975 Aug 16;2(7929):300-2
Date
Aug-16-1975
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Alkaline Phosphatase - blood
Calcium - blood
Clinical Trials as Topic
Denmark
Femoral Fractures - blood - epidemiology - etiology
Great Britain
Humans
Hydroxycholecalciferols - blood - metabolism
Kidney - metabolism
Middle Aged
Osteomalacia - blood - complications - etiology
Phosphorus - blood
Seasons
Vitamin D - administration & dosage
Abstract
Plasma 25-hydroxycholecalciferol (25-H.C.C.) has been measured in 67 consective cases of fracture of the proximal femur. The values found in these patients were not different from values found in these patients were not different from those in control groups at the same time of the year. Plasma 25-H.C.C. was not correlated to plasma calcium or phosphorus, the Ca times P product, or the alkaline phosphatase. X-rays showed Looser zones in only 1 patient, in whom the lowest plasma 25-H.C.C. was found. Osteomalacia is not uncommon among elderly people in Denmark, but it is more likely to depend on a decline in the renal efficiency to convert 25-H.C.C. to 1,25-dihydroxycholecalciferol than a low dietary intake of vitamin D.
PubMed ID
50509 View in PubMed
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25-hydroxyvitamin D accumulation during summer in elderly women at latitude 60 degrees N.

https://arctichealth.org/en/permalink/ahliterature149948
Source
J Intern Med. 2009 Nov;266(5):476-83
Publication Type
Article
Date
Nov-2009
Author
Ann Burgaz
A. Akesson
K. Michaëlsson
A. Wolk
Author Affiliation
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. ann.burgaz@ki.se
Source
J Intern Med. 2009 Nov;266(5):476-83
Date
Nov-2009
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Middle Aged
Questionnaires
Seasons
Sunlight
Sweden
Ultraviolet Rays
Vitamin D - analogs & derivatives - blood
Abstract
During half of the year, cutaneous synthesis of 25-hydroxyvitamin D (25(OH)D) is not detectable at northern latitudes, leaving the population dependent on other sources for optimal vitamin D status. During April to September, 25(OH)D status may be improved by solar exposure. In this study, we measured seasonal differences in serum 25(OH)D concentrations and identified the major predictors of summer 25(OH)D concentrations.
We assessed serum 25(OH)D concentrations during both winter and summer amongst 100 women, aged 61-83 years, randomly sampled from the Swedish Mammography Cohort. Participants completed two detailed questionnaires covering diet, use of dietary supplements and sun-related behaviour, the first in January through March and a second time in August through September.
The mean seasonal increase in serum 25(OH)D concentrations was 38% from mean 72 +/- 23 nmol L(-1) during winter to 99 +/- 29 nmol L(-1) in summer. High summer 25(OH)D concentrations were associated with higher winter concentrations, preference of staying in sun instead of shade, having a nonsensitive skin type and normal body mass index. Based on multiple linear regression modelling, preferring sun, having nonsensitive skin type and normal weight as compared with preferring shade, having sensitive skin type and being obese, was associated with a 64 nmol L(-1) higher 25(OH)D concentrations during summer.
Women with high winter 25(OH)D serum concentrations, with preference of staying in the sun instead of shade during summer, a skin type allowing for longer sun exposure and a normal weight had the highest summer 25(OH)D concentrations.
PubMed ID
19570054 View in PubMed
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25-Hydroxyvitamin D and Peripheral Immune Mediators: Results from Two Nationwide Danish Pediatric Cohorts.

https://arctichealth.org/en/permalink/ahliterature285851
Source
Nutrients. 2017 Apr 06;9(4)
Publication Type
Article
Date
Apr-06-2017
Author
Steffen U Thorsen
Christian B Pipper
Kristin Skogstrand
Flemming Pociot
Jannet Svensson
Source
Nutrients. 2017 Apr 06;9(4)
Date
Apr-06-2017
Language
English
Publication Type
Article
Keywords
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Denmark
Diabetes Mellitus, Type 1 - blood - diagnosis
European Continental Ancestry Group
Female
Humans
Immunologic Factors - blood
Infant, Newborn
Interleukin-8 - blood
Leptin - blood
Male
Vitamin D - analogs & derivatives - blood
Abstract
(1) Background: We aimed to examine if 25-hydroxyvitamin D (25(OH)D) was related to the peripheral immunological and inflammatory signature both at birth, and in newly diagnosed patients with childhood type 1 diabetes (T1D) and their healthy controls; (2) Methods: The birth cohort consisted of 470 patients and 500 healthy controls. Dried blood samples were collected from the neonates in the period 1981-1999. The newly diagnosed cohort consisted of 460 patients and 453 siblings. Serum samples were collected in the period 1997-2005. A variety of peripheral immune mediators were measured and compared to total 25(OH)D levels (25(OH)D2 + 25(OH)D3). For each immune mediator, the relative change (RC) in the mean level was modeled by robust log-normal regression and correction for multiple testing was performed; (3) Results: Two associations were identified; there was a negative association between 25(OH)D (10 nmol/L increase) and leptin (RC (95% confidence interval (CI)), 0.98 (0.96; 1.00)), and a positive association between 25(OH)D (10 nmol/L increase) and the chemokine, chemokine (c-x-c motif) ligand (CXCL) 8 (RC (95% CI), 1.07 (1.01; 1.13)); (4) Conclusion: CXCL8 and leptin have significant associations with levels of 25(OH)D in the newly diagnosed cohort. These results do not indicate a strong influence of 25(OH)D on the peripheral immunological or inflammatory signature.
Notes
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PubMed ID
28383493 View in PubMed
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25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis.

https://arctichealth.org/en/permalink/ahliterature118271
Source
Ann Neurol. 2013 Jan;73(1):38-47
Publication Type
Article
Date
Jan-2013
Author
Peter Brøndum-Jacobsen
Børge G Nordestgaard
Peter Schnohr
Marianne Benn
Author Affiliation
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark.
Source
Ann Neurol. 2013 Jan;73(1):38-47
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Aged
Biological Markers - blood
Brain Ischemia - blood - diagnosis - epidemiology
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Population Surveillance - methods
Prospective Studies
Risk factors
Stroke - blood - diagnosis - epidemiology
Vitamin D - analogs & derivatives - blood
Abstract
We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk of symptomatic ischemic stroke in the general population.
We measured plasma 25-hydroxyvitamin D in 10,170 individuals from the general population, the Copenhagen City Heart Study. During 21 years of follow-up, 1,256 and 164 persons developed ischemic and hemorrhagic stroke, respectively. In a meta-analysis of ischemic stroke, we included 10 studies, 58,384 participants, and 2,644 events.
Stepwise decreasing plasma 25-hydroxyvitamin D concentrations were associated with stepwise increasing risk of ischemic stroke both as a function of seasonally adjusted percentile categories and as a function of clinical categories of 25-hydroxyvitamin D (p for trend = 2 × 10(-3)). In a Cox regression model comparing individuals with plasma 25-hydroxyvitamin D concentrations between the 1st and 4th percentiles to individuals with 25-hydroxyvitamin D concentrations between the 50th and 100th percentiles, multivariate adjusted hazard ratio of ischemic stroke was 1.82 (95% confidence interval, 1.41-2.34). Comparing individuals with clinical categories of severe vitamin D deficiency (
PubMed ID
23225498 View in PubMed
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25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966.

https://arctichealth.org/en/permalink/ahliterature273332
Source
Am J Epidemiol. 2016 Feb 1;183(3):191-8
Publication Type
Article
Date
Feb-1-2016
Author
Dylan M Williams
Saranya Palaniswamy
Sylvain Sebert
Jessica L Buxton
Alexandra I F Blakemore
Elina Hyppönen
Marjo-Riitta Jarvelin
Source
Am J Epidemiol. 2016 Feb 1;183(3):191-8
Date
Feb-1-2016
Language
English
Publication Type
Article
Keywords
Adiposity
Adult
Body mass index
C-Reactive Protein - metabolism
Cross-Sectional Studies
Female
Finland
Humans
Leukocytes
Male
Prospective Studies
Telomere Homeostasis
Vitamin D - analogs & derivatives - blood
Abstract
Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)(2)) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = -0.4%, 95% confidence interval: -0.6, -0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = -0.3%, 95% confidence interval -0.6, -0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL.
Notes
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PubMed ID
26797572 View in PubMed
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25-Hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants.

https://arctichealth.org/en/permalink/ahliterature117634
Source
J Thromb Haemost. 2013 Mar;11(3):423-31
Publication Type
Article
Date
Mar-2013
Author
P. Brøndum-Jacobsen
M. Benn
A. Tybjaerg-Hansen
B G Nordestgaard
Author Affiliation
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Source
J Thromb Haemost. 2013 Mar;11(3):423-31
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biological Markers - blood
Denmark
Down-Regulation
Female
Humans
Incidence
Kaplan-Meier Estimate
Linear Models
Male
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Risk assessment
Risk factors
Seasons
Time Factors
Venous Thromboembolism - blood - diagnosis - epidemiology
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - blood - diagnosis - epidemiology
Abstract
Vitamin D has potential antithrombotic effects, suggesting that vitamin D analogs could be used as adjunctive antithrombotic agents. However, epidemiologic evidence of an association between reduced 25-hydroxyvitamin D concentrations and the risk of venous thromboembolism is lacking.
To test the hypothesis that reduced plasma 25-hydroxyvitamin D concentrations are associated with an increased risk of venous thromboembolism in the general population.
We prospectively studied 18 791 participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. During up to 30 years of follow-up, 950 participants were diagnosed with venous thromboembolism. Plasma 25-hydroxyvitamin D concentrations were adjusted for seasonal variation.
The cumulative incidence of venous thromboembolism as a function of age increased with decreasing tertiles of seasonally adjusted plasma 25-hydroxyvitamin D (log-rank trend: P = 4 × 10(-4) ). On comparison of participants in the lowest and the highest tertile of plasma 25-hydroxyvitamin D concentrations, the crude risk estimate in a model adjusted for age and sex was a 37% (95% confidence interval [CI] 15-64%) increased risk of venous thromboembolism. The corresponding risk increase in a model adjusted for age, sex, body mass index, smoking and cancer was 26% (95% CI 5-51%), and in a multivariable-adjusted model also including physical activity, hormone replacement therapy, menopausal status, oral contraception use and lipid-lowering therapy it was 28% (95% CI 6-53%). Furthermore, corresponding risk increases with attempts to correct for regression dilution bias were 103% (95% CI 37-202%), 70% (95% CI 14-155%) and 73% (95% CI 15-160%) in the three models, respectively.
In these large general population studies, we observed a stepwise increasing risk of venous thromboembolism with decreasing tertiles of seasonally adjusted plasma 25-hydroxyvitamin D concentrations.
PubMed ID
23279309 View in PubMed
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25-Hydroxyvitamin D concentrations in maternal and cord blood at delivery and in maternal blood during lactation in Finland.

https://arctichealth.org/en/permalink/ahliterature240391
Source
Hum Nutr Clin Nutr. 1984 Jul;38(4):261-8
Publication Type
Article
Date
Jul-1984
Author
C. Lamberg-Allardt
M. Larjosto
E. Schultz
Source
Hum Nutr Clin Nutr. 1984 Jul;38(4):261-8
Date
Jul-1984
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alkaline Phosphatase - blood
Calcifediol - blood
Calcium - blood
Cholecalciferol - administration & dosage
Female
Fetal Blood - metabolism
Finland
Food Habits
Humans
Infant, Newborn
Lactation
Maternal-Fetal Exchange
Nutritional Requirements
Pregnancy
Seasons
Vitamin D Deficiency - blood
Abstract
The 25-hydroxyvitamin D concentration (25-OHD) in maternal and cord blood of 192 mothers was determined at delivery from June to the end of November. Ninety-nine mothers had received a daily supplementation of 12.5 micrograms of vitamin D during pregnancy and this group had a significantly higher 25-OHD concentration both in maternal and in cord blood than in the corresponding non-supplemented group. A daily supplement of 2.5 micrograms of vitamin D was given to 63 of the mothers during lactation. Of these mothers 44 were still lactating after 6 months. The dietary vitamin D intake of 31 mothers was calculated. We found a significant correlation between the maternal serum 25-OHD concentration 16-18 weeks after delivery and the total vitamin D intake. The intake (5.5 micrograms/d, including supplementation) was lower than that recommended for lactating mothers which is 10 micrograms/d (Food and Nutrition Board, 1980).
PubMed ID
6088438 View in PubMed
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25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort.

https://arctichealth.org/en/permalink/ahliterature286504
Source
Neurology. 2017 Oct 10;89(15):1578-1583
Publication Type
Article
Date
Oct-10-2017
Author
Kassandra L Munger
Kira Hongell
Julia Åivo
Merja Soilu-Hänninen
Heljä-Marja Surcel
Alberto Ascherio
Source
Neurology. 2017 Oct 10;89(15):1578-1583
Date
Oct-10-2017
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Case-Control Studies
Cohort Studies
Female
Finland - epidemiology
Humans
Middle Aged
Multiple Sclerosis - blood - epidemiology
Pregnancy - blood
Severity of Illness Index
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - blood - epidemiology
Young Adult
Abstract
To determine whether and to what extent vitamin D deficiency is associated with multiple sclerosis (MS) risk.
We conducted a prospective nested case-control study among women in the Finnish Maternity Cohort (FMC). The FMC had 1.8 million stored serum samples taken during the pregnancies of over 800,000 women at the time of this study. Through linkages with hospital and prescription registries, we identified 1,092 women with MS diagnosed between 1983 and 2009 with at least 1 serum sample collected prior to date of MS diagnosis; =2 serum samples were available for 511 cases. Cases were matched to up to 3 controls (n = 2,123) on date of birth (±2 years) and area of residence. 25-Hydroxyvitamin D (25[OH]D) levels were measured using a chemiluminescence assay. We used conditional logistic regression adjusted for year of sample collection, gravidity, and parity to estimate relative risks (RRs) and 95% confidence intervals (CIs).
A 50 nmol/L increase in 25(OH)D was associated with a 39% reduced risk of MS (RR 0.61, 95% CI 0.44-0.85), p = 0.003. Women with 25(OH)D levels
Notes
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PubMed ID
28904091 View in PubMed
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25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates.

https://arctichealth.org/en/permalink/ahliterature141385
Source
Osteoporos Int. 2011 May;22(5):1389-99
Publication Type
Article
Date
May-2011
Author
L S Greene-Finestone
C. Berger
M. de Groh
D A Hanley
N. Hidiroglou
K. Sarafin
S. Poliquin
J. Krieger
J B Richards
D. Goltzman
Author Affiliation
Public Health Agency of Canada, Ottawa, Ontario, Canada. linda.greene-finestone@phac-aspc.gc.ca
Source
Osteoporos Int. 2011 May;22(5):1389-99
Date
May-2011
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Body mass index
Canada - epidemiology
Cross-Sectional Studies
Diet - statistics & numerical data
Dietary Supplements
Female
Humans
Male
Middle Aged
Obesity - complications - epidemiology
Seasons
Sex Distribution
Skin Pigmentation - physiology
Sunlight
Vitamin D - administration & dosage - analogs & derivatives - blood
Vitamin D Deficiency - blood - epidemiology - etiology
Abstract
We assessed vitamin D status and its correlates in the population-based Canadian Multicentre Osteoporosis Study (CaMos). Results showed that serum 25-hydroxyvitamin D levels
PubMed ID
20730415 View in PubMed
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