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Cross-species transplantation of the suprachiasmatic nuclei from rats to Siberian chipmunks (Eutamias sibiricus) with suprachiasmatic lesions.

https://arctichealth.org/en/permalink/ahliterature55271
Source
Neurosci Lett. 1991 Feb 11;123(1):77-81
Publication Type
Article
Date
Feb-11-1991
Author
Y. Saitoh
Y. Matsui
I. Nihonmatsu
H. Kawamura
Author Affiliation
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Source
Neurosci Lett. 1991 Feb 11;123(1):77-81
Date
Feb-11-1991
Language
English
Publication Type
Article
Keywords
Animals
Arrhythmia - physiopathology
Brain Tissue Transplantation - physiology
Circadian Rhythm
Fetal Tissue Transplantation - physiology
Immunohistochemistry
Male
Motor Activity
Rats
Sciuridae
Suprachiasmatic Nucleus - cytology - physiology - surgery
Transplantation, Heterologous
Vasoactive Intestinal Peptide - analysis
Vasopressins - analysis
Abstract
Suprachiasmatic nuclei (SCN) obtained from neonatal or embryonic 19 or 20 day rats, were grafted into the third ventricle of SCN-lesioned arrhythmic siberian chipmunks. Four out of 37 chipmunks showed reappearance of circadian rhythmicity in wheel running activity. In all 4 cases, at least one surviving graft was confirmed in the host brain. Also, vasopressin and vasoactive intestinal polypeptide (VIP)-like immunoreactive substances were found in the graft, suggesting the existence of live SCN neurons. Although the number of successful cases and the intensity of the restored rhythm was limited compared to the intra-species grafting in rats, a possibility that cross-species transplantation of SCN can restore circadian rhythmicity was shown.
PubMed ID
2062456 View in PubMed
Less detail

Neuroimmune appendicitis, peptides, and schizophrenia.

https://arctichealth.org/en/permalink/ahliterature200303
Source
Lancet. 1999 Nov 6;354(9190):1648
Publication Type
Article
Date
Nov-6-1999