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184 records – page 1 of 19.

A 3-year follow-up of sun behavior in patients with cutaneous malignant melanoma.

https://arctichealth.org/en/permalink/ahliterature106960
Source
JAMA Dermatol. 2014 Feb;150(2):163-8
Publication Type
Article
Date
Feb-2014
Author
Luise Winkel Idorn
Pameli Datta
Jakob Heydenreich
Peter Alshede Philipsen
Hans Christian Wulf
Author Affiliation
Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Source
JAMA Dermatol. 2014 Feb;150(2):163-8
Date
Feb-2014
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Denmark
Female
Follow-Up Studies
Health Behavior
Humans
Male
Melanoma - etiology - pathology
Middle Aged
Prospective Studies
Risk factors
Skin Neoplasms - etiology - pathology
Sunlight - adverse effects
Time Factors
Ultraviolet Rays - adverse effects
Abstract
IMPORTANCE UV radiation (UVR) exposure is the primary environmental risk factor for developing cutaneous malignant melanoma (CMM). OBJECTIVE To measure changes in sun behavior from the first until the third summer after the diagnosis of CMM using matched controls as a reference. DESIGN, SETTING, AND PARTICIPANTS Three-year follow-up, observational, case-control study performed from May 7 to September 22, 2009, April 17 to September 15, 2010, and May 6 to July 31, 2011, at a university hospital in Denmark of 21 patients with CMM and 21 controls matched to patients by sex, age, occupation, and constitutive skin type participated in the study. Exposure to UVR was assessed the first and second summers (n=20) and the first and third summers (n=22) after diagnosis. Data from 40 participants were analyzed. MAIN OUTCOMES AND MEASURES Exposure to UVR was assessed by personal electronic UVR dosimeters that measured time-related UVR in standard erythema dose (SED) and corresponding sun diaries (mean, 74 days per participant each participation year). RESULTS Patients' daily UVR dose and UVR dose in connection with various behaviors increased during follow-up (quantified as an increase in daily UVR dose each year; all days: mean, 0.3 SED; 95% CI, 0.05-0.5 SED; days with body exposure: mean, 0.6 SED; 95% CI, 0.07-1.2 SED; holidays: mean, 1.2 SED; 95% CI, 0.3-2.1 SED; days abroad: 1.9 SED; 95% CI, 0.4-3.4 SED; and holidays with body exposure: mean, 2.3 SED; 95% CI, 1.1-3.4 SED). After the second year of follow-up, patients' UVR dose was higher than that of controls, who maintained a stable UVR dose. No difference was found between groups in the number of days with body exposure or the number of days using sunscreen in the second and third years of follow-up. CONCLUSIONS AND RELEVANCE Our findings suggest that patients with CMM do not maintain a cautious sun behavior in connection with an increase in UVR exposure, especially on days with body exposure, when abroad, and on holidays.
PubMed ID
24080851 View in PubMed
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7 years experience of photopatch testing with sunscreen allergens in Sweden.

https://arctichealth.org/en/permalink/ahliterature33993
Source
Contact Dermatitis. 1998 Feb;38(2):61-4
Publication Type
Article
Date
Feb-1998
Author
B. Berne
A M Ros
Author Affiliation
Department of Dermatology, University Hospital, Uppsala, Sweden.
Source
Contact Dermatitis. 1998 Feb;38(2):61-4
Date
Feb-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Allergens - administration & dosage - adverse effects
Child
Dermatitis, Allergic Contact - diagnosis - etiology
Dermatitis, Photoallergic - diagnosis - etiology
Female
Humans
Male
Middle Aged
Multicenter Studies
Patch Tests
Severity of Illness Index
Skin - drug effects - pathology - radiation effects
Sunscreening Agents - administration & dosage - adverse effects
Sweden
Ultraviolet Rays - adverse effects
Urticaria - chemically induced
Abstract
Since 1990 7 sunscreen allergens have been included in the standard photopatch protocol at 2 Swedish dermatology clinics. 355 consecutive patients with suspected photosensitivity were tested, and in 28 of these (7.9%), a total of 42 allergic reactions were found. 80% of the reactions were of photocontact origin. The most common allergen was benzophenone-3 (Eusolex 4360), with 15 photocontact and 1 contact allergic reactions, followed by isopropyl dibenzoylmethane (Eusolex 8020) (8 photocontact, 4 contact) and butyl methoxydibenzoylmethane (Parsol 1789), with 6 photocontact reactions. There were 2 cases of photocontact allergy to phenylbenzimidazole sulfonic acid (Eusolex 232), which has not been reported previously. 1 case of contact urticaria from benzophenone-3 was accidentally found. In addition, 21 + reactions of doubtful relevance were noted in 14 patients: 16 on irradiated and 5 on non-irradiated test sites. Among these, irritant and phototoxic reactions may be included. These results indicate that the inclusion of UV filters in the standard photopatch protocol is important. Immediate-type testing for urticaria could also be of value.
PubMed ID
9506215 View in PubMed
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Accessibility to air travel correlates strongly with increasing melanoma incidence.

https://arctichealth.org/en/permalink/ahliterature16510
Source
Melanoma Res. 2006 Feb;16(1):77-81
Publication Type
Article
Date
Feb-2006
Author
Yolanda Z Agredano
Joanna L Chan
Ranch C Kimball
Alexa B Kimball
Author Affiliation
Department of Dermatology, Stanford University Medical Center, Stanford, California, USA.
Source
Melanoma Res. 2006 Feb;16(1):77-81
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Aircraft
Comparative Study
Environmental Exposure - adverse effects
Holidays - statistics & numerical data
Humans
Incidence
Income - statistics & numerical data
Melanoma - diagnosis - epidemiology - etiology
Middle Aged
Norway - epidemiology
Skin Neoplasms - diagnosis - epidemiology - etiology
Sunlight
Travel - statistics & numerical data
Ultraviolet Rays - adverse effects
United States - epidemiology
Abstract
As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader population who could not previously afford this kind of travel. The purpose of this study was to analyse the correlation between increasing accessibility to air travel and melanoma incidence. This ecological study surveyed air travel patterns and melanoma incidence over the past three decades. Melanoma age-adjusted incidence was obtained from the United States Surveillance, Epidemiology, and End Results 9 Registry Database, 1975-2000, and the Cancer Registry of Norway, 1965-2000. United States mean inflation-adjusted airfare prices for four airports linked to leisure destinations (Miami, Los Angeles, San Diego, Phoenix) were compared with melanoma incidence. Parallel analyses were performed using annual domestic passenger-kilometres and melanoma incidence in Norway. Declining United States leisure-specific airfares corresponded strongly with increasing melanoma incidence (r = 0.96, r = 0.92, P
PubMed ID
16432460 View in PubMed
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[A comparative analysis of the existing standards for exposure to ultraviolet radiation].

https://arctichealth.org/en/permalink/ahliterature208776
Source
Usp Fiziol Nauk. 1997 Apr-Jun;28(2):94-106
Publication Type
Article
Author
A D Strzhizhovskii
Source
Usp Fiziol Nauk. 1997 Apr-Jun;28(2):94-106
Language
Russian
Publication Type
Article
Keywords
Animals
Dose-Response Relationship, Radiation
Humans
Maximum Allowable Concentration
Neoplasms, Radiation-Induced - etiology
Netherlands
Occupational Exposure - adverse effects - standards - statistics & numerical data
Russia
Time Factors
Ultraviolet Rays - adverse effects
United States
Abstract
Quantitative analysis of threshold limit levels of UV-irradiation in the workroom environment established in USA, Netherlands and Russia was made. Comparison of its results with modern information about effective doses and action spectra of UV-radiation biological action allowed to reveal essential differences in the approach to rate setting and in some cases presence of internal contradictions and exceeding of threshold limit levels of UV irradiation above biologically effective values. The possibility of workroom UV standards utilisation for regulation of nature UV-radiation exposures was considered.
PubMed ID
9235809 View in PubMed
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[A consensus statement for the prevention of melanoma. Changes in sunbathing habits are most important. Tanning salons are too popular among young people].

https://arctichealth.org/en/permalink/ahliterature216688
Source
Lakartidningen. 1994 Dec 14;91(50):4778-82
Publication Type
Conference/Meeting Material
Article
Date
Dec-14-1994

Aetiology of spheroidal degeneration of the cornea in Labrador.

https://arctichealth.org/en/permalink/ahliterature244607
Source
Br J Ophthalmol. 1981 Apr;65(4):270-83
Publication Type
Article
Date
Apr-1981
Author
G J Johnson
Source
Br J Ophthalmol. 1981 Apr;65(4):270-83
Date
Apr-1981
Language
English
Publication Type
Article
Keywords
Adult
Aged
Corneal Diseases - epidemiology - etiology
Female
Humans
Humidity
Ice
Male
Middle Aged
Newfoundland and Labrador
Snow
Temperature
Ultraviolet Rays - adverse effects
Wind
Abstract
To determine the aetiology of spheroidal degeneration of the cornea (Labrador keratopathy), total population surveys were conducted in 5 communities in coastal Labrador and northern Newfoundland. For 4 years records were also kept on all clinic patients aged 40 or more throughout the region. Both methods gave a peak prevalence at latitudes 55 degrees--56 degrees north. The greatest severity and earliest age of onset occurred around the same latitudes. Of the proposed environmental causative agents only ultraviolet radiation, reflected from ice and snow, explains the distribution of the disease. The high cumulative UV dosage is due to the unique geographical and climatic features of the region.
Notes
Cites: Exp Eye Res. 1965 Dec;4(4):355-635867355
Cites: Acta Ophthalmol (Copenh). 1972;50(4):532-84678271
Cites: Am J Ophthalmol. 1972 Nov;74(5):821-84539458
Cites: Arch Ophthalmol. 1973 Jan;89(1):36-454630887
Cites: Arch Ophthalmol. 1973 Mar;89(3):193-74120598
Cites: Can J Ophthalmol. 1973 Apr;8(2):298-3054541018
Cites: Acta Ophthalmol (Copenh). 1974;52(6):777-854549005
Cites: Can J Ophthalmol. 1975 Apr;10(2):119-351125837
Cites: Am J Pathol. 1977 Dec;89(3):718-808339743
Cites: Br J Ophthalmol. 1978 Jan;62(1):53-61629911
Cites: Arch Ophthalmol. 1965 Aug;74:198-20214318495
PubMed ID
7236572 View in PubMed
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Allergic and photoallergic contact dermatitis: a 10-year experience.

https://arctichealth.org/en/permalink/ahliterature117016
Source
Dermatitis. 2013 Jan-Feb;24(1):29-32
Publication Type
Article
Author
Jill Greenspoon
Renita Ahluwalia
Naznin Juma
Cheryl F Rosen
Author Affiliation
Schulich School of Medicine and Dentistry, London, Ontario, Canada. jillgreenspoon@gmail.com
Source
Dermatitis. 2013 Jan-Feb;24(1):29-32
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Allergens - adverse effects
Canada - epidemiology
Dermatitis, Allergic Contact - epidemiology - etiology
Dermatitis, Photoallergic - epidemiology - etiology
Female
Humans
Male
Middle Aged
Patch Tests - methods
Photosensitizing Agents - adverse effects
Retrospective Studies
Sunscreening Agents - adverse effects
Ultraviolet Rays - adverse effects
Young Adult
Abstract
Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction that occurs when a previously photosensitized exogenous agent comes into contact with UV radiation. Currently, there are no studies profiling photoallergic reactions in Canada. Because the photoallergen profile changes over time, it is necessary to continually update our knowledge to ensure proper recognition of allergens and appropriate treatment of patients.
This study aimed to profile photoallergic reactions in Canada.
A retrospective chart review of all patients who underwent photopatch testing at Toronto Western Hospital between January 2001 and December 2010 was completed. Photoallergic, allergic, and irritant reactions were recorded for 26 common allergens.
Ninety-nine patients (61.9%) had at least 1 positive reaction to the test allergens. Fifty-four patients (33.8%) had at least 1 photoallergic reaction. All 26 allergens produced at least 1 allergic or photoallergic reaction. The most common relevant photoallergens were benzophenone-3, octyl dimethyl para-aminobenzoic acid (PABA) in 5% alcohol, and butylmethoxy-dibenzoylmethane.
This study is the first to profile photoallergic contact reactions in Canada. It is clear that the culprit photoallergen in PACD can often be identified in a properly selected population. Future surveillance is necessary to continue to characterize PACD trends in Canada and to help better treat and screen this patient population.
PubMed ID
23340396 View in PubMed
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Analysis of the risk of skin cancer from sunlight and solaria in subjects living in northern Europe.

https://arctichealth.org/en/permalink/ahliterature235096
Source
Photodermatol. 1987 Jun;4(3):118-26
Publication Type
Article
Date
Jun-1987
Author
B L Diffey
Author Affiliation
Regional Medical Physics Department, Dryburn Hospital, Durham, UK.
Source
Photodermatol. 1987 Jun;4(3):118-26
Date
Jun-1987
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Analysis of Variance
Carcinoma, Basal Cell - epidemiology
Carcinoma, Squamous Cell - epidemiology
Child
Germany, West
Great Britain
Humans
Middle Aged
Models, Theoretical
Occupations
Risk factors
Scandinavia
Skin Neoplasms - epidemiology
Sunlight - adverse effects
Ultraviolet Rays - adverse effects
Abstract
The risk of non-melanoma skin cancer in northern Europeans who indulge in sunbathing or use a UVA solarium was estimated using a mathematical model of skin cancer incidence that makes allowance for childhood, occupational and recreational sun exposure. This model demonstrates that the cumulative incidence of skin cancer in indoor workers is about 2-3% by the age of 70, yet this risk can increase 5-fold if they indulge in a two-week sunbathing vacation each summer. The use of a UVA solarium is also shown to increase the risk of skin cancer. Because risk increases with the approximate square of annual solarium exposure, it is not possible to define a 'safe' level of exposure. Instead, it is shown that weekly use of a UVA solarium from age 20 until middle age (40-50) gives a relative cumulative incidence of 1.3 compared with non-users of sun beds and sun canopies. The risk begins to increase rapidly for more frequent use, particularly when solaria are used in combination with sunbathing.
PubMed ID
3684734 View in PubMed
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Anti-inflammatory effects of tectroside on UVB-induced HaCaT cells.

https://arctichealth.org/en/permalink/ahliterature114711
Source
Int J Mol Med. 2013 Jun;31(6):1471-6
Publication Type
Article
Date
Jun-2013
Author
Sung-Bae Kim
Ok-Hwa Kang
Dae-Ki Joung
Su-Hyun Mun
Yun-Soo Seo
Mi-Ran Cha
Shi-Yong Ryu
Dong-Won Shin
Dong-Yeul Kwon
Author Affiliation
Institute of Biotechnology, Wonkwang University, Jeonbuk, Republic of Korea.
Source
Int J Mol Med. 2013 Jun;31(6):1471-6
Date
Jun-2013
Language
English
Publication Type
Article
Keywords
Anti-Inflammatory Agents - chemistry - pharmacology
Asteraceae - chemistry
Cell Line
Cell Survival - drug effects - radiation effects
Cyclooxygenase 2 - genetics
Gene Expression Regulation - drug effects
Humans
Interleukin-6 - biosynthesis
Interleukin-8 - biosynthesis
Keratinocytes - drug effects - metabolism - radiation effects
Lactones - chemistry - pharmacology
Mitogen-Activated Protein Kinases - metabolism
Phosphorylation
Plant Extracts - chemistry - pharmacology
RNA, Messenger - genetics
Sesquiterpenes, Guaiane - chemistry - pharmacology
Ultraviolet Rays - adverse effects
Abstract
Ultraviolet B (UVB) irradiation causes skin damage and inflammation by inducing the secretion of various cytokines, which are immune regulators produced by cells. To prevent skin inflammation, keratinocytes that have been irreversibly damaged by UVB must be eliminated through apoptosis. Ixeris dentata (I.?dentata) (family Asteraceae) is a perennial medicinal herb indigenous to Korea. It is used in Korea, China and Japan to treat indigestion, pneumonia, diabetes, hepatitis, contusions and tumors. Guaiane-type sesquiterpene lactones were isolated from the whole extract of I.?dentata. This led to the isolation of the anti-inflammatory sesquiterpene lactone compound tectroside (TES), which was tested on a human keratinocyte cell line. To determine the anti-inflammatory effects of TES, we examined its influence on UVB-induced pro-inflammatory cytokine production in human keratinocytes (HaCaT cells) by observing these cells in the presence or absence of TES. In the present study, pro-inflammatory cytokine production was determined by performing enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction and western blot analysis to evaluate the activation of mitogen-activated protein kinases (MAPKs). TES inhibited UVB-induced production of the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in a dose-dependent manner. In addition, TES inhibited the expression of cyclooxygenase (COX)-2 and the phosphorylation of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8 and COX-2 expression by blocking MAPK phosphorylation. These results suggest that TES can potentially protect against UVB-induced skin inflammation.
PubMed ID
23588209 View in PubMed
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Association of cutaneous malignant melanoma with intermittent exposure to ultraviolet radiation: results of a case-control study in Ontario, Canada.

https://arctichealth.org/en/permalink/ahliterature201487
Source
Int J Epidemiol. 1999 Jun;28(3):418-27
Publication Type
Article
Date
Jun-1999
Author
S D Walter
W D King
L D Marrett
Author Affiliation
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. walter@mcmaster.ca
Source
Int J Epidemiol. 1999 Jun;28(3):418-27
Date
Jun-1999
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Environmental Exposure
Female
Humans
Male
Melanoma - etiology
Neoplasms, Radiation-Induced - epidemiology
Ontario - epidemiology
Risk assessment
Skin Neoplasms - etiology
Time Factors
Ultraviolet Rays - adverse effects
Abstract
Although solar radiation is well established as a risk factor for melanoma, it is less clear how the pattern and timing of exposure to ultraviolet (UV) radiation might be important. The particular objective of this study was to evaluate the association of melanoma risk with various measures of intermittent and chronic exposures to UV radiation, and to assess how these exposures interact with other risk factors such as skin type.
Data were analysed from a large case-control study (583 cases, 608 controls) of malignant melanoma, carried out in southern Ontario, Canada.
Significant risk increases were identified with several measures of intermittent exposure, including beach vacations in adolescence and in the past 5 years, previous sunburn, and use of sunbeds and sunlamps. Chronic exposure, indicated by days of outdoor activity during adolescence and by occupation in recent adult life, was associated with significantly reduced risk. Subgroup analyses showed: no major risk differences by body site of melanoma; stronger association of lentigo maligna melanoma with intermittent exposure; more pronounced effects of beach vacations and sunburn in younger subjects; and consistently higher risks for intermittent exposures among subjects with skin more susceptible to burning.
The data lend limited support to the hypothesis of increased risk associated with intermittent UV exposure. The findings suggest that future studies should take age at diagnosis, host susceptibility and histological subtype into account.
PubMed ID
10405843 View in PubMed
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184 records – page 1 of 19.