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5. Nonmalignant diseases after the Chernobyl catastrophe.

https://arctichealth.org/en/permalink/ahliterature146767
Source
Ann N Y Acad Sci. 2009 Nov;1181:58-160
Publication Type
Article
Date
Nov-2009
Author
Alexey V Yablokov
Author Affiliation
Russian Academy of Sciences, Leninsky Prospect 33, Office 319, 119071 Moscow, Russia. Yablokov@ecopolicy.ru
Source
Ann N Y Acad Sci. 2009 Nov;1181:58-160
Date
Nov-2009
Language
English
Publication Type
Article
Keywords
Chernobyl Nuclear Accident
Humans
Radiation Injuries - epidemiology - genetics - immunology - metabolism
Republic of Belarus - epidemiology
Russia - epidemiology
Ukraine - epidemiology
Abstract
This section describes the spectrum and the scale of the nonmalignant diseases that have been found among exposed populations. Adverse effects as a result of Chernobyl irradiation have been found in every group that has been studied. Brain damage has been found in individuals directly exposed--liquidators and those living in the contaminated territories, as well as in their offspring. Premature cataracts; tooth and mouth abnormalities; and blood, lymphatic, heart, lung, gastrointestinal, urologic, bone, and skin diseases afflict and impair people, young and old alike. Endocrine dysfunction, particularly thyroid disease, is far more common than might be expected, with some 1,000 cases of thyroid dysfunction for every case of thyroid cancer, a marked increase after the catastrophe. There are genetic damage and birth defects especially in children of liquidators and in children born in areas with high levels of radioisotope contamination. Immunological abnormalities and increases in viral, bacterial, and parasitic diseases are rife among individuals in the heavily contaminated areas. For more than 20 years, overall morbidity has remained high in those exposed to the irradiation released by Chernobyl. One cannot give credence to the explanation that these numbers are due solely to socioeconomic factors. The negative health consequences of the catastrophe are amply documented in this chapter and concern millions of people.
PubMed ID
20002045 View in PubMed
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15 years after Chernobyl: new evidence of thyroid cancer.

https://arctichealth.org/en/permalink/ahliterature19395
Source
Lancet. 2001 Dec 8;358(9297):1965-6
Publication Type
Article
Date
Dec-8-2001
Author
Y. Shibata
S. Yamashita
V B Masyakin
G D Panasyuk
S. Nagataki
Source
Lancet. 2001 Dec 8;358(9297):1965-6
Date
Dec-8-2001
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Byelarus - epidemiology
Child
Female
Humans
Male
Mass Screening
Neoplasms, Radiation-Induced - epidemiology
Nuclear Reactors
Population Surveillance
Radioactive fallout
Research Support, Non-U.S. Gov't
Thyroid Neoplasms - epidemiology - etiology
Ukraine - epidemiology
Abstract
The Chernobyl nuclear power plant accident happened on April 26, 1986. We investigated the cause of the striking increase in frequency of thyroid cancer in children who lived within a 150 km radius of Chernobyl and who were born before and after the accident. No thyroid cancer was seen in 9472 children born in 1987-89, whereas one and 31 thyroid cancers were recorded in 2409 children born April 27, 1986, to Dec 31, 1986, and 9720 born Jan 1, 1983, to April 26, 1986, respectively. Short-lived radioactive fallout caused by the Chernobyl accident probably induced thyroid cancer in children living near Chernobyl.
PubMed ID
11747925 View in PubMed
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[15 years after the accident at the Chernobyl Nuclear Power Plant]

https://arctichealth.org/en/permalink/ahliterature19138
Source
Radiats Biol Radioecol. 2002 Mar-Apr;42(2):228-33
Publication Type
Article
Author
L A Buldakov
A K Gus'kova
Author Affiliation
State Research Centre-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia.
Source
Radiats Biol Radioecol. 2002 Mar-Apr;42(2):228-33
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Adult
Age Factors
Byelarus - epidemiology
Child
Child, Preschool
Comparative Study
English Abstract
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Neoplasms, Radiation-Induced - epidemiology - etiology
Power Plants
Pregnancy
Prognosis
Radiation Dosage
Radiation Injuries - epidemiology
Risk factors
Russia - epidemiology
Thyroid Neoplasms - epidemiology - etiology
Time Factors
Ukraine - epidemiology
Abstract
Health effects as a result of the accident at the Chernobyl nuclear power plant occurred in 1986 are considered in the paper. Wrong prognosis of the health effects with respect to mortality and morbidity among the population exposed to low radiation doses is shown. Proven increase in thyroid cancer cases among people who were children aged from 0 to 18 at the time of the accident is shown. Linear relationship between thyroid cancer cases and dose to thyroid ranged from 0.2 to 4.0 Gy is considered. An additional absolute risk of thyroid cancer in children varies in the range 1.9-2.6 cases per 10(4) person-year Gy. During the fifteen years following the accident no cases of acute and chronic radiation sickness have been revealed because the population living in contaminated areas received low radiation doses. Also, exposures to low radiation doses did not result in excess of malignant tumors among population. In some cases the outcomes of acute radiation sickness were as follows: radiation damages to the skin, cancer cataracts, development of oncopathology.
PubMed ID
12004624 View in PubMed
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[A combined lesion of the digestive organs and chronic inflammatory diseases of the large intestine]

https://arctichealth.org/en/permalink/ahliterature20919
Source
Lik Sprava. 1999 Mar;(2):74-7
Publication Type
Article
Date
Mar-1999
Author
S I Skliar
A I Denisiuk
N A Moskvichev
L I Prusskaia
S N Kirilko
A R Sapozhnikov
Source
Lik Sprava. 1999 Mar;(2):74-7
Date
Mar-1999
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Autopsy - statistics & numerical data
Cause of Death
Chronic Disease
Colitis - mortality - pathology
Colonic Neoplasms - mortality - pathology
Comparative Study
Digestive System Diseases - mortality - pathology
English Abstract
Humans
Male
Middle Aged
Military Personnel - statistics & numerical data
Ukraine - epidemiology
Abstract
An analysis was carried out of 222 medical records and autopsies from patients with inflammatory diseases of the large intestine, the immediate causes of death of whom were different disorders. The incidence of hepatitis running an active course correlated with age of patients and came up to 58.8% in the group of subjects 20 to 40 years old. In age group running between 40 to 60 and 60 to 80 years there prevailed colorectal carcinoma (18.3% and 42.5% respectively).
PubMed ID
10424048 View in PubMed
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[Acute leukemia in adults: morbidity in Donetsk region of Ukraine before and after Chernobyl' accident]

https://arctichealth.org/en/permalink/ahliterature20591
Source
Ter Arkh. 2000;72(1):60-2
Publication Type
Article
Date
2000
Author
V N Mukhin
Source
Ter Arkh. 2000;72(1):60-2
Date
2000
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Adult
Comparative Study
English Abstract
Humans
Incidence
Leukemia, Radiation-Induced - epidemiology
Power Plants
Retrospective Studies
Survival Rate
Time Factors
Ukraine - epidemiology
Abstract
AIM: To study whether Chernobyl accident has implications for acute leukemia (AL) incidence rate in Donetsk region. MATERIALS AND METHODS: Records of the Donetsk regional hematological center for new verified cases of AL have been analysed for 1977-1987 and 1989-1994. RESULTS: Four years after the accident AL morbidity was higher than before the accident. After 1991 AL morbidity returned to the preaccident level. CONCLUSION: A rise in AL incidence is attributed to radionuclide contamination after the Chernobyl accident of a region with initially unfriendly environment.
PubMed ID
10687211 View in PubMed
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Acute leukemias in children from the city of Kiev and Kiev region after the Chernobyl NPP catastrophe.

https://arctichealth.org/en/permalink/ahliterature20944
Source
Pediatr Hematol Oncol. 1999 Jul-Aug;16(4):355-60
Publication Type
Article
Author
D F Gluzman
I V Abramenko
L M Sklyarenko
V A Nadgornaya
M P Zavelevich
N I Bilous
L Y Poludnenko
Author Affiliation
RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Source
Pediatr Hematol Oncol. 1999 Jul-Aug;16(4):355-60
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Child
Child, Preschool
Female
Humans
Leukemia, Lymphocytic, Acute, L1 - epidemiology
Leukemia, Myelocytic, Acute - epidemiology
Leukemia, Radiation-Induced - epidemiology
Male
Power Plants
Ukraine - epidemiology
Abstract
During 1993-1997, 247 cases of childhood acute leukemia (AL) were analyzed among inhabitants of the city of Kiev and Kiev region, excluding the most contaminated areas belonging to the strict control zone. The criteria of an FAB classification supplemented by immunophenotyping data were applied. The AL pattern was shown to be quite typical except for several peculiar features characteristic of this regional group of patients, especially the absence of age peaks in children with acute myelogenous leukemias (AML), increased frequency of the T1 variant in T-cell acute lymphoblastic leukemia (ALL), and higher levels of M4 and M5 variants in AML. A typical variant of M5a-AML with minimal signs of differentiation was found.
PubMed ID
10407873 View in PubMed
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[Allelic polymorphism of endothelial NO-synthase (T(-786)-->C) promoter gene as risk factor of acute coronary syndrome]

https://arctichealth.org/en/permalink/ahliterature53180
Source
Fiziol Zh. 2005;51(1):72-6
Publication Type
Article
Date
2005
Author
V Ie Dosenko
V Iu Zahorii
Ia M Lutai
O M Parkhomenko
O O Moibenko
Source
Fiziol Zh. 2005;51(1):72-6
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Acute Disease
Adult
Aged
Aged, 80 and over
Alleles
Coronary Disease - enzymology - epidemiology - genetics
English Abstract
Female
Genetic Predisposition to Disease
Genetic Screening
Humans
Male
Middle Aged
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type III
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Promoter Regions (Genetics)
Risk factors
Ukraine - epidemiology
Abstract
Frequency of promoter endothelial NO-synthase gene allelic polymorphism by using polymerase chain reaction and restriction fragment length polymorphism (RFLP-PCR) was determined in 221 patients with acute coronary syndrome (ACS) and in 83 almost healthy subjects. Data obtained indicate that different promoter allelic variant frequency differs significantly in patients with ACS and in control group. Correlation of normal homozygotes (T/T), heterozygotes (T/C) and pathologic homozygotes (C/C) was 48%, 36% and 16% respectively in patients, and in control it was 48%, 46%, 6% (P
PubMed ID
15801202 View in PubMed
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725 records – page 1 of 73.