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Acetowhitening of the cervix and vulva as a predictor of subclinical human papillomavirus infection: sensitivity and specificity in a population-based study.

https://arctichealth.org/en/permalink/ahliterature21915
Source
Obstet Gynecol. 1997 Nov;90(5):744-7
Publication Type
Article
Date
Nov-1997
Author
M. Jonsson
R. Karlsson
M. Evander
A. Gustavsson
E. Rylander
G. Wadell
Author Affiliation
Department of Family Medicine, University of Umeå, Sweden.
Source
Obstet Gynecol. 1997 Nov;90(5):744-7
Date
Nov-1997
Language
English
Publication Type
Article
Keywords
Acetic Acid - administration & dosage
Adult
Cervix Uteri - pathology - virology
Colposcopy
DNA, Viral - analysis
Female
Humans
Indicators and Reagents - administration & dosage
Papillomavirus, Human - isolation & purification
Papovaviridae Infections - epidemiology - pathology
Predictive value of tests
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Tumor Virus Infections - epidemiology - pathology
Vaginal Smears
Vulva - pathology - virology
Abstract
OBJECTIVE: To evaluate acetowhite changes of the cervix and vulva as a predictor of human papillomavirus (HPV) infection. METHODS: In this population-based study all women aged 19, 21, 23, and 25 years and registered as living in a primary health care area within the city of Umeå, Sweden were eligible for inclusion. Each participant underwent a gynecologic examination with sampling of epithelial cells for HPV-DNA detection and Papanicolaou smear. Colposcopy was performed 5 minutes after application of 5% acetic acid. A two-step polymerase chain reaction (PCR) technique was employed for HPV-DNA detection. RESULTS: Colposcopy and sampling of epithelial cells could be performed in 535 women. The sensitivity of detection of HPV infection by the acetowhitening of the cervix was 22% (95% confidence interval [CI] 18%, 26%). The specificity of detection of HPV infection by the acetowhitening of the cervix was 90% (95% CI 87%, 93%). The sensitivity of detection of HPV infection by cytology was 13% (95% CI 10%, 16%), and the specificity was 99% (95% CI 98%, 100%). The combination of acetowhitening and cytology did not improve the diagnostic value. CONCLUSION: Acetowhitening of the cervix and vulva has low sensitivity as a predictor of HPV infections as determined by PCR.
PubMed ID
9351757 View in PubMed
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[Focal epithelial hyperplasia: first cases in Switzerland and review of the literature]

https://arctichealth.org/en/permalink/ahliterature4212
Source
Dermatologica. 1985;171(5):308-15
Publication Type
Article
Date
1985
Author
J. Samson
G. Fiore-Donno
N. Avizara
Source
Dermatologica. 1985;171(5):308-15
Date
1985
Language
French
Publication Type
Article
Keywords
Adult
English Abstract
Female
Humans
Hyperplasia - pathology
Male
Microscopy, Electron
Middle Aged
Mouth Diseases - epidemiology - etiology - pathology
Mouth Mucosa - pathology
Papillomavirus - isolation & purification
Switzerland
Tumor Virus Infections - epidemiology - pathology
Abstract
Three cases of 'focal epithelial hyperplasia' (FEH) of the oral mucosa observed for the first time in Switzerland are reported. The patients were of Turkish and North African extraction. The lesions of FEH were multiple, painless, located at various sites of the oral mucosa including the tongue, in the form of either soft papules or hard nodules. Evidence of a human papilloma virus origin was ascertained. Among the 1,067 cases reported in the literature and reviewed for this study, this condition has been described to occur among American Indians, Eskimos and Cape Coloureds; also in Israeli and European cases the disorder was often reported in individuals of Turkish or North African extraction.
PubMed ID
3000842 View in PubMed
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HPV infection in cervical-cancer cases in Russia.

https://arctichealth.org/en/permalink/ahliterature215150
Source
Int J Cancer. 1995 May 4;61(3):337-41
Publication Type
Article
Date
May-4-1995
Author
E V Samoylova
G O Shaikhaiev
S V Petrov
N P Kisseljova
F L Kisseljov
Author Affiliation
Department of Molecular Biology of Viruses, Academy of Medical Science, Moscow, Russia.
Source
Int J Cancer. 1995 May 4;61(3):337-41
Date
May-4-1995
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - pathology - virology
Base Sequence
Blotting, Southern
Carcinoma, Squamous Cell - pathology - therapy - virology
Cell Line
Cervix Uteri - virology
DNA Primers
DNA, Viral - analysis
Epithelium - virology
Female
Humans
Molecular Sequence Data
Neoplasm Staging
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology - pathology - virology
Polymerase Chain Reaction
Prevalence
Reference Values
Russia - epidemiology
Tumor Virus Infections - epidemiology - pathology - virology
Uterine Cervical Neoplasms - pathology - therapy - virology
Abstract
The presence of human papillomavirus (HPV) sequences in 21 biopsies from cervical carcinomas, 11 specimens of tissues adjacent to tumours, 2 specimens of cervical tissues with radiation fibrosis from patients after radiation therapy of cervical cancer and 7 normal epithelial tissues from the patients with other genital tumours were examined by polymerase chain reaction (PCR) and Southern-blot analysis. All tumours were HPV-positive by type-specific PCR and 86% by Southern-blot analysis. In normal epithelial and adjacent tissues, HPV sequences were detected in 20% of samples by Southern-blot analysis and in 70% of samples by PCR, including 2 cases of tissues after radiation therapy. HPV16 was the most prevalent type in tumours (18/21) as well as in normal epithelial tissues (5/7). One HPV-positive tumour contained HPV18 DNA and 2 were doubly infected with HPVs 16 and 18 (2/21). The persistence of exclusively episomal HPV16 DNA was observed in 5 out of 11 tumours examined: 3 cases of squamous-cell carcinomas on the early stage of tumour progression and 2 advanced tumours (squamous-cell carcinoma and adenocarcinoma). The integration of HPV16 genome was detected in 6 out of 11 tumours, but most of them contained episomal forms of viral DNA simultaneously (5 out of 6). The integrative HPV18 genome was found in 2 tumours examined, and the persistence of episomal forms was also observed in one of them. Our data demonstrate that cervical tumours are associated invariably with high-risk types of HPV in Russia.
PubMed ID
7729945 View in PubMed
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Human papilloma virus infection among women attending an STD clinic correlated to reason for attending, presence of clinical signs, concomitant infections and abnormal cytology.

https://arctichealth.org/en/permalink/ahliterature23414
Source
Acta Derm Venereol. 1995 Jan;75(1):75-8
Publication Type
Article
Date
Jan-1995
Author
E. Voog
A. Bolmstedt
S. Olofsson
W. Ryd
G B Löwhagen
Author Affiliation
Department of Dermato-Venerology, Sahlgrenska Hospital, Gothenburg, Sweden.
Source
Acta Derm Venereol. 1995 Jan;75(1):75-8
Date
Jan-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Candidiasis, Vulvovaginal - epidemiology - pathology
Chlamydia Infections - epidemiology - pathology
Chlamydia trachomatis - isolation & purification
Comorbidity
Condylomata Acuminata - epidemiology - pathology - virology
DNA, Viral - analysis
Female
Follow-Up Studies
Humans
Middle Aged
Papillomavirus, Human - genetics - isolation & purification
Papovaviridae Infections - epidemiology - pathology
Sexually Transmitted Diseases - epidemiology - pathology
Sweden - epidemiology
Tumor Virus Infections - epidemiology - pathology
Uterine Cervical Diseases - epidemiology - pathology - virology
Vaginal Diseases - epidemiology - pathology - virology
Vaginal Smears
Vulvar Diseases - epidemiology - pathology - virology
Abstract
The purpose of this study was to demonstrate the prevalence of cervical human papilloma virus (HPV) infection correlated to reason for attending an STD clinic, presence of clinical signs of HPV infection, concomitant infection and abnormal cytology. Samples from the cervical canals of 588 consecutive women attending the STD clinic, Department of Dermato-Venereology, Sahlgrenska Hospital, Gothenburg, were taken with a Cytobrush for detection of HPV DNA with the dot blot/Southern-blot technique. Visible condylomata, i.e. filiform or papular condylomata, were registered. Acetic acid test and colposcopy were not routinely performed. Cytological examination was performed as well as isolation of Chlamydia trachomatis on Mc Coy's cells and culture on Sabouraud agar for Candida albicans. The prevalence of HPV DNA was 8% (48/588). In the group of 233 women attending because of concern about HPV infection, 94 (40%) had visible signs of HPV infection and 30 (13%) were positive for HPV DNA in the cervix. In 355 women attending for other reasons, such as discharge, pruritus or STD check-up, 4 (1%) had visible signs of HPV infection and 18 (5%) were HPV DNA positive. Of 98 women with visible signs of vulvar/vaginal HPV infection, 33 (34%) were HPV-positive in the cervix with a commercial Southern-blot test. Of 490 patients without visible signs of HPV infection, 15 (3%) were HPV-positive in the cervix. In the group of HPV-positive women a positive culture for Candida was demonstrated in 26% (11/43), Compared to 16% (79/504) of the HPV-negative women.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
7747543 View in PubMed
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Persistent human papillomavirus infection and cervical neoplasia.

https://arctichealth.org/en/permalink/ahliterature190900
Source
Lancet Oncol. 2002 Jan;3(1):11-6
Publication Type
Article
Date
Jan-2002
Author
Alex Ferenczy
Eduardo Franco
Author Affiliation
McGill University and the Sir Mortimer B Davis Jewish General Hospital, Montreal, Québec, Canada. aferen@po-box.mcgill.ca
Source
Lancet Oncol. 2002 Jan;3(1):11-6
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Biopsy, Needle
Canada - epidemiology
Chronic Disease
Female
Humans
Incidence
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology - pathology
Precancerous Conditions - pathology - virology
Prognosis
Risk assessment
Tumor Virus Infections - epidemiology - pathology
Uterine Cervical Neoplasms - epidemiology - pathology - virology
Abstract
The development of cervical cancer is preceded by precursor lesions (cervical intraepithelial neoplasia). Evidence-based epidemiological and molecular data suggest that persistent infections with human papillomavirus (HPV) types that carry ahigh oncogenic risk are the intermediate endpoints, leading to both intraepithelial and invasive cervical neoplasia. Integration of highly oncogenic HPVs into host-cell chromosomes is followed by binding of HPV E6 and E7 oncoproteins to tumour-suppressor genes p53 and RB, respectively. This process results in impaired tumour-suppressor-gene function, involving DNA repair, decreased apoptosis, and eventual cell immortalisation. Mutations causing chromosomal alterations, loss of heterozygosity, and proto-oncogene and telomerase activation in immunopermissive individuals have important roles in virus-induced cervical carcinogenesis. The so-called non-European variants of HPV 16 and 18 may increase the degradation potential of p53. HPV 16 is polymorphic and, although the evidence is controversial, the Arg/Arg genotype of p53 could have greater susceptibility to HPV-E6 degradation than the other genotypes. The coincident interplay between the non-European genomic variants of HPV 16/18 and p53 Arg/Arg may explain, at least in part, the persistence of HPV infection and tumour progression in women with cervical neoplasia. Further epidemiological and molecular research is needed, to gain insight into HPV-mediated cervical carcinogenesis. The evidence highlights the need to develop appropriate prophylactic HPV vaccines and diagnostic and screening tests.
PubMed ID
11905599 View in PubMed
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Prevalence of genital human papillomavirus infections in a mass-screened Finnish female population aged 20-65 years.

https://arctichealth.org/en/permalink/ahliterature228176
Source
Int J STD AIDS. 1990 Nov;1(6):410-5
Publication Type
Article
Date
Nov-1990
Author
K. Syrjänen
M. Yliskoski
V. Kataja
M. Hippeläinen
S. Syrjänen
S. Saarikoski
A. Ryhänen
Author Affiliation
Department of Pathology, University of Kuopio, Finland.
Source
Int J STD AIDS. 1990 Nov;1(6):410-5
Date
Nov-1990
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Female
Finland - epidemiology
Genital Neoplasms, Female - epidemiology - pathology - prevention & control
Humans
Mass Screening - methods - standards
Middle Aged
Papanicolaou test
Papillomaviridae
Prevalence
Tumor Virus Infections - epidemiology - pathology - prevention & control
Vaginal Smears - standards
Abstract
The results of the nationwide, population-based cervical cancer screening programme (organized by the Finnish Cancer Society since early 1960s) were analysed to establish the prevalence figures (and their changes) for genital human papillomavirus (HPV) infections in an unselected Finnish female population (aged between 20 and 65 years) screened in Kuopio Province between 1981 and 1989. During the study period 82,393 women were invited on a regular basis for the mass-screening, and also 4131 women in a risk group. Of these, a total of 63,115 and 3249 women attended, resulting in the attendance rates of 76.6% and 78.6%, respectively. As a result of the screening, a total of 509 (0.80%) of the 63,115 smears were diagnosed as having the cytological changes consistent with HPV infection in the mass screening. The corresponding figures in the risk group screening were 58/3249 (1.78%). There was a sharply increasing trend in the prevalence of genital HPV infections from 1981 through 1987, from 0.04% to 1.76% (ie a 44-fold increase in 7 years) which, surprisingly, then declined to 1.43% in 1988 and 1.04% in 1989. Based on a random sample of 2084 routine (non-mass-screening) Pap smears (out of (28,861) collected from the files of our laboratory, the prevalence of HPV infections was stratified by age groups. The highest prevalence (6.1%) was observed in women aged between 20 and 29 years, followed by 2.2% in those aged 30-39 years. Using the figures of the relative risk (RR) of HPV infections by age, an estimation was made to assess the prevalence of clinical HPV infections in the Finnish female population in general.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
1965568 View in PubMed
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7 records – page 1 of 1.