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The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.

https://arctichealth.org/en/permalink/ahliterature47878
Source
J Clin Endocrinol Metab. 2000 Apr;85(4):1731-4
Publication Type
Article
Date
Apr-2000
Author
S K Rasmussen
S A Urhammer
J N Jensen
T. Hansen
K. Borch-Johnsen
O. Pedersen
Author Affiliation
Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark.
Source
J Clin Endocrinol Metab. 2000 Apr;85(4):1731-4
Date
Apr-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Birth Weight - genetics
Body constitution
Body mass index
Denmark
Diabetes Mellitus, Type 2 - genetics
Female
Genotype
Humans
Insulin - blood
Insulin Resistance - genetics
Lipids - blood
Male
Obesity - genetics
Polymorphism, Restriction Fragment Length
Promoter Regions (Genetics)
Research Support, Non-U.S. Gov't
Tumor Necrosis Factor-alpha - genetics
Abstract
Recently, two G-->A polymorphisms at positions -308 and -238, in the promoter of the tumor necrosis factor alpha (TNF-alpha) gene, have been identified. These variants have, in different ethnic groups, been linked to estimates of insulin resistance and obesity. The objective of the present study was to investigate whether these genetic variants of TNF-alpha were associated with features of the insulin resistance syndrome or alterations in birth weight in two Danish study populations comprising 380 unrelated young healthy subjects and 249 glucose-tolerant relatives of type 2 diabetic patients, respectively. All study participants underwent an iv glucose tolerance test with the addition of tolbutamide after 20 min. In addition, a number of biochemical and anthropometric measures were performed on each subject. The subjects were genotyped for the polymorphisms by applying PCR restriction fragment length polymorphism. Neither of the variants was related to altered insulin sensitivity index or other features of the insulin resistance syndrome (body mass index, waist to hip ratio, fat mass, fasting serum lipids or fasting serum insulin or C-peptide). Birth weight and the ponderal index were also not associated with the polymorphisms. In conclusion, although the study was carried out on sufficiently large study samples, the study does not support a major role of the -308 or -238 substitutions of the TNF-alpha gene in the pathogenesis of insulin resistance or altered birth weight among Danish Caucasian subjects.
PubMed ID
10770222 View in PubMed
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alpha-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation.

https://arctichealth.org/en/permalink/ahliterature51606
Source
Transplantation. 2002 Dec 27;74(12):1678-84
Publication Type
Article
Date
Dec-27-2002
Author
Stefano Gatti
Gualtiero Colombo
Roberto Buffa
Flavia Turcatti
Letizia Garofalo
Nadia Carboni
Luca Ferla
Luigi R Fassati
James M Lipton
Anna Catania
Author Affiliation
Division of Liver Transplantation, Ospedale Maggiore di Milano IRCCS, Milano, Italy.
Source
Transplantation. 2002 Dec 27;74(12):1678-84
Date
Dec-27-2002
Language
English
Publication Type
Article
Keywords
Animals
Endothelin-1 - genetics
Gene Expression - drug effects
Graft Rejection - drug therapy - immunology - pathology
Graft Survival - drug effects - immunology
Heart Transplantation
Intercellular Adhesion Molecule-1 - genetics
Interferon Type II - genetics
Interleukin-1 - genetics
Male
Membrane Glycoproteins - genetics
Monocyte Chemoattractant Protein-1 - genetics
Nitrates - blood
Nitric Oxide - blood
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type II
Nitrites - blood
Proto-Oncogene Proteins c-sis - genetics
RANTES - genetics
Rats
Rats, Inbred BN
Rats, Inbred Lew
Research Support, Non-U.S. Gov't
Transforming Growth Factor beta - genetics
Transplantation, Homologous
Tumor Necrosis Factor-alpha - genetics
Vascular Cell Adhesion Molecule-1 - genetics
alpha-MSH - pharmacology
Abstract
BACKGROUND: With the increasing need for organ transplantation and the use of "marginal" organs, novel approaches are sought to increase the efficiency and survival of transplanted tissue. We tested the idea that treatment with the anti-inflammatory peptide, alpha-melanocyte-stimulating hormone (alpha-MSH), an endogenous hormone that does not cause marked immunosuppression but does reduce reperfusion injury, may protect allografts and prolong their survival. METHODS: Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats. Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection. Allografts were removed on day 1, day 4, or at the time of rejection and examined for histopathology and expression of molecules prominent in reperfusion injury, transplant rejection, and apoptosis. RESULTS: NDP-alpha-MSH treatment caused a significant increase in allograft survival and a marked decrease in leukocyte infiltration. Expression of molecules such as endothelin 1, chemokines, and adhesion molecules, which are involved in allograft rejection, was significantly inhibited in NDP-alpha-MSH-treated rats. CONCLUSIONS: The results indicate that protection of the allograft from early injury with alpha-MSH can postpone rejection. Addition of this early protection with the peptide to usual treatment with immunosuppressive agents may, therefore, improve success of organ transplants.
PubMed ID
12499879 View in PubMed
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[Analysis of linkage and association of alleles of proinflammatory cytokines genes IL-6, IFNg and TNF with multiple sclerosis using transmission disequilibrium test (TDT)].

https://arctichealth.org/en/permalink/ahliterature139177
Source
Mol Biol (Mosk). 2010 Sep-Oct;44(5):824-30
Publication Type
Article
Author
O Iu Makarycheva
E Iu Tsareva
M A Sudomoina
O G Kulakova
O V Bykova
N V Gol'tsova
L M Kuzenkova
A N Boiko
O O Favorova
Source
Mol Biol (Mosk). 2010 Sep-Oct;44(5):824-30
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Child
Female
Genetic Predisposition to Disease - ethnology - genetics
Humans
Interferon-gamma - genetics
Interleukin-6 - genetics
Linkage Disequilibrium
Male
Multiple Sclerosis - ethnology - genetics
Polymorphism, Single Nucleotide
Russia
Tumor Necrosis Factor-alpha - genetics
Abstract
Proinflammatory cytokines Interleukin-6 (IL-6), Interferon-gamma (IFNg) and Tumor necrosis factor (TNF) are known as participants of inflammation and play an important role in pathogenesis of multiple sclerosis (MS). Based on literature data about influence of SNPs G(-308)A of TNF gene, A(+874)T of IFNG gene and G(-174)C of IL-6 gene on production of these cytokines, we investigated association of these polymorphic sites with MS. Linkage and association of alleles of these genes with MS was analyzed by transmission disequilibrium test (TDT). In investigated group of 104 nuclear families of Russian ethnicity it was found that TNF* (-308)A allele transmitted from healthy heterozygous parents to affected children more frequently (p = 0.01). Linkage/association of IFNG and IL-6 alleles with MS was not revealed. Thus, data obtained indicate the participation of TNF gene in MS susceptibility in Russians.
PubMed ID
21090238 View in PubMed
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Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia.

https://arctichealth.org/en/permalink/ahliterature296966
Source
Bull Exp Biol Med. 2018 Sep; 165(5):674-677
Publication Type
Journal Article
Date
Sep-2018
Author
I E Malysheva
L V Topchieva
O V Balan
I M Marusenko
O Yu Barysheva
I V Kurbatova
Author Affiliation
Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia. ie.malysheva@yandex.ru.
Source
Bull Exp Biol Med. 2018 Sep; 165(5):674-677
Date
Sep-2018
Language
English
Publication Type
Journal Article
Keywords
Alleles
Arthritis, Rheumatoid - diagnosis - ethnology - genetics - pathology
Case-Control Studies
Female
Gene Expression
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Risk factors
Russia
Tumor Necrosis Factor-alpha - genetics
Abstract
We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele.
PubMed ID
30225702 View in PubMed
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An association study of 21 potential Alzheimer's disease risk genes in a Finnish population.

https://arctichealth.org/en/permalink/ahliterature141682
Source
J Alzheimers Dis. 2010;21(3):763-7
Publication Type
Article
Date
2010
Author
Timo Sarajärvi
Seppo Helisalmi
Leila Antikainen
Petra Mäkinen
Anne Maria Koivisto
Sanna-Kaisa Herukka
Annakaisa Haapasalo
Hilkka Soininen
Mikko Hiltunen
Author Affiliation
Institute of Clinical Medicine-Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Source
J Alzheimers Dis. 2010;21(3):763-7
Date
2010
Language
English
Publication Type
Article
Keywords
Alleles
Alzheimer Disease - genetics
Databases, Factual
European Continental Ancestry Group - genetics
Finland
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Genetic
Risk
Tumor Necrosis Factor-alpha - genetics
Abstract
Alzheimer's disease (AD) is a genetically complex disorder encompassing several individual susceptibility genes with low risk effects. To assess the risk gene effects in a cohort consisting of ~ 1300 Finnish AD patients and controls, 21 candidate gene polymorphisms were selected for genotyping on the basis of the meta-analyses retrieved from the AlzGene database. A significant genotype and allele association with AD was observed with rs1800629 in the tumor necrosis factor a (TNF). Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD.
PubMed ID
20693638 View in PubMed
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[A retrospective study of patients with early onset of multiple sclerosis in Omskaya Oblast].

https://arctichealth.org/en/permalink/ahliterature123674
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2 Pt 2):16-21
Publication Type
Article
Date
2012
Author
A V Kakulia
A S Rozhdestvenskii
E V Khanokh
R A Delov
M L Filipenko
Source
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2 Pt 2):16-21
Date
2012
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Alleles
Child
Disease Progression
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Multiple Sclerosis - diagnosis - epidemiology - genetics
Optic Neuritis - diagnosis - epidemiology
Polymorphism, Genetic
Retrospective Studies
Siberia - epidemiology
Tumor Necrosis Factor-alpha - genetics
Young Adult
Abstract
To study the features of multiple sclerosis (MS) with child age-at-onset, we examined 254 patients with confirmed diagnosis of MS. The disease developed at the age younger than 16 years in 27 patients. A control group included 303 healthy volunteers. Correlations between the rate of disease progression and the age-at-onset were found. The more benign course of MS was noted in patients with earlier disease onset. There were more women and the disease frequently manifested with retrobulbar nephritis in the group with early onset. The results indicated that a G allele of -308G/A polymorphism of the TNF-a gene might be a risk factor for MS. The A allele may play a protective function. No association between -137G/C IL-18 polymorphism and MS was found. These polymorphisms did not contribute to the predisposition to early onset of MS.
PubMed ID
22677674 View in PubMed
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Association between genetic variants in the tumour necrosis factor/lymphotoxin a/lymphotoxin ß locus and primary Sjogren's syndrome in Scandinavian samples.

https://arctichealth.org/en/permalink/ahliterature127439
Source
Ann Rheum Dis. 2012 Jun;71(6):981-8
Publication Type
Article
Date
Jun-2012
Author
Anne Isine Bolstad
Stephanie Le Hellard
Gudlaug Kristjansdottir
Lilian Vasaitis
Marika Kvarnström
Christopher Sjöwall
Svein Joar Auglænd Johnsen
Per Eriksson
Roald Omdal
Johan G Brun
Marie Wahren-Herlenius
Elke Theander
Ann-Christine Syvänen
Lars Rönnblom
Gunnel Nordmark
Roland Jonsson
Author Affiliation
Department of Clinical Dentistry--Periodontics, University of Bergen, Bergen, Norway. anne.bolstad@iko.uib.no
Source
Ann Rheum Dis. 2012 Jun;71(6):981-8
Date
Jun-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cohort Studies
European Continental Ancestry Group - genetics - statistics & numerical data
Female
Genetic Predisposition to Disease - epidemiology - genetics
Genetic Variation
Haplotypes
Humans
Linkage Disequilibrium
Lymphotoxin-alpha - genetics - immunology
Lymphotoxin-beta - genetics - immunology
Male
Middle Aged
Norway - epidemiology
Polymorphism, Single Nucleotide
Risk factors
Salivary Glands - immunology
Sjogren's Syndrome - epidemiology - genetics - immunology
Sweden - epidemiology
Tumor Necrosis Factor-alpha - genetics - immunology
Abstract
Lymphotoxin ? (LTB) has been found to be upregulated in salivary glands of patients with primary Sj?gren's syndrome (pSS). An animal model of pSS also showed ablation of the lymphoid organisation and a marked improvement in salivary gland function on blocking the LTB receptor pathway. This study aimed to investigate whether single-nucleotide polymorphisms (SNP) in the lymphotoxin a (LTA)/LTB/tumour necrosis factor (TNF) gene clusters are associated with pSS.
527 pSS patients and 532 controls participated in the study, all of Caucasian origin from Sweden and Norway. 14 SNP markers were genotyped and after quality control filtering, 12 SNP were analysed for their association with pSS using single marker and haplotype tests, and corrected by permutation testing.
Nine markers showed significant association with pSS at the p=0.05 level. Markers rs1800629 and rs909253 showed the strongest genotype association (p=1.64E-11 and p=4.42E-08, respectively, after correcting for sex and country of origin). When the analysis was conditioned for the effect of rs1800629, only the association with rs909253 remained nominally significant (p=0.027). In haplotype analyses the strongest effect was observed for the haplotype rs909253G_rs1800629A (p=9.14E-17). The associations were mainly due to anti-Ro/SSA and anti-La/SSB antibody-positive pSS.
A strong association was found between several SNP in the LTA/LTB/TNFa locus and pSS, some of which led to amino acid changes. These data suggest a role for this locus in the development of pSS. Further studies are needed to examine if the genetic effect described here is independent of the known genetic association between HLA and pSS.
PubMed ID
22294627 View in PubMed
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Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study.

https://arctichealth.org/en/permalink/ahliterature145403
Source
Arch Otolaryngol Head Neck Surg. 2010 Feb;136(2):187-92
Publication Type
Article
Date
Feb-2010
Author
Leandra Mfuna Endam
Chantale Cormier
Yohan Bossé
Abdelali Filali-Mouhim
Martin Desrosiers
Author Affiliation
Department of Otolaryngology, Centre de Recherche du Centre Hospitalier de l'Université de Montréal Hôtel-Dieu, Canada.
Source
Arch Otolaryngol Head Neck Surg. 2010 Feb;136(2):187-92
Date
Feb-2010
Language
English
Publication Type
Article
Keywords
Adult
Aged
Canada
Case-Control Studies
Chronic Disease
Female
Humans
Interleukin-1alpha - genetics
Interleukin-1beta - genetics
Male
Middle Aged
Nasal Polyps - genetics
Polymorphism, Single Nucleotide
Rhinitis - genetics
Sinusitis - genetics
Tumor Necrosis Factor-alpha - genetics
Abstract
To replicate and extend recent findings in a Turkish population of associations between chronic rhinosinusitis (CRS) with nasal polyposis and single-nucleotide polymorphisms (SNPs) in the IL1A (rs17561 and Ser114Ala), IL1B (rs16944), and TNF (rs361525 and rs1800629) genes.
In a case-control replication study, DNA samples were obtained from 206 patients with severe CRS (cases) and from 196 postal code-matched controls. For IL1A and TNF, the 3 reported SNPs were complemented with tagging SNPs using an International HapMap genotyping data set to ensure complete genetic coverage. For IL1B, only the single reported SNP was assessed. A total of 24 SNPs (7 in IL1A, 1 in IL1B, and 16 in TNF) were individually genotyped. The PLINK software package was used to perform genetic association tests.
Academic research.
Canadian population of individuals with severe CRS.
Allelic differences between cases and controls.
Significant allelic differences between cases and controls were obtained for IL1A rs17561 (odds ratio [OR], 1.48; P = .02). The following 3 additional SNPs in this gene were associated with CRS: rs2856838 (OR, 0.63; P = .003), rs2048874 (OR, 0.57; P = .01), and rs1800587 (OR, 1.49; P = .02). These 3 SNPs remained significant after correction for multiple testing. No association was found with IL1B or TNF.
We replicated the previously reported association between the IL1A polymorphism and severe CRS and identified 3 potential new associations in the same gene. This further supports the potential contribution of IL1A to the development of CRS. We were unable to replicate previous reports of associations with IL1B or TNF.
PubMed ID
20157068 View in PubMed
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Association of the -159 CD14 gene polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians.

https://arctichealth.org/en/permalink/ahliterature175159
Source
J Clin Periodontol. 2005 May;32(5):474-9
Publication Type
Article
Date
May-2005
Author
Mauro Donati
Tord Berglundh
Ann-Marie Hytönen
Mirjana Hahn-Zoric
Lars-A Hanson
Leonid Padyukov
Author Affiliation
Department of Periodontology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. mauro.donati@odontologi.gu.se
Source
J Clin Periodontol. 2005 May;32(5):474-9
Date
May-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alleles
Alveolar Bone Loss - genetics - immunology
Antigens, CD14 - genetics
Case-Control Studies
Chronic Disease
European Continental Ancestry Group - genetics
Female
Gene Frequency
Humans
Male
Middle Aged
Periodontitis - genetics - immunology
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Receptors, Interleukin-4 - antagonists & inhibitors
Sweden
Tumor Necrosis Factor-alpha - genetics
Abstract
Severe forms of periodontitis are suggested to have a genetic basis.
The aim of the present investigation was to study the association of gene polymorphisms related to some immune regulation components (G-308A TNFA, Q551R IL-4RA and C-159T CD14) with severe chronic periodontitis.
Sixty patients (aged 36-74 years; mean 54.5+/-8.5) with severe and generalized chronic periodontitis were included. The patients exhibited bone loss >50% at all teeth. Thirty-nine periodontally healthy subjects between 35 and 78 years of age (mean 51.0+/-10.9) were recruited as controls. DNA was isolated from peripheral blood cells and genotyping was performed by combination of PCR and restriction endonuclease mapping.
While gene polymorphisms for TNFA and IL-4RA did not show any association with severe chronic periodontitis, the analysis of the -159 CD14 gene polymorphism revealed significant differences between test and control groups. The proportion of subjects that exhibited the TT genotype was significantly smaller in the group with severe periodontitis than in periodontal healthy group (p=0.028; Fisher's exact test). The C allele carriage was 90% in the periodontitis group and significantly higher than in the healthy control group (72%).
It is suggested that the -159 CD14 gene polymorphism is associated with chronic periodontitis in Caucasian subjects of a north European origin.
PubMed ID
15842262 View in PubMed
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60 records – page 1 of 6.