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131I content in the human thyroid estimated from direct measurements of the inhabitants of Russian areas contaminated due to the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature30700
Source
Radiat Prot Dosimetry. 2003;105(1-4):623-6
Publication Type
Article
Date
2003
Author
A A Bratilova
I A Zvonova
M I Balonov
N G Shishkanov
V I Trushin
M. Hoshi
Author Affiliation
Institute of Radiation Hygiene, Mira st. 8, 197136, St Petersburg, Russia. bratilov@comset.net
Source
Radiat Prot Dosimetry. 2003;105(1-4):623-6
Date
2003
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Adult
Aged
Child
Child, Preschool
Computer simulation
Female
Humans
Infant
Infant, Newborn
Iodine Radioisotopes - analysis - pharmacokinetics
Male
Metabolic Clearance Rate
Middle Aged
Models, Biological
Power Plants
Radiation Dosage
Radioactive fallout - analysis
Radiometry - methods
Russia
Thyroid Gland - metabolism
Ukraine
Abstract
The method of processing and the results of measurements of 131I content in the thyroids of Russian people performed in May-June 1986 are presented. The contribution of radiation from Cs radionuclides in the human body was taken into account in the processing of measurement data with an SRP-68-01 device. The greatest individual 131I content was found in the thyroids of inhabitants of the Bryansk region, up to 250-350 kBq, and in the Tula and Orel regions, up to 100 kBq. The average 131I thyroid activity in the middle of May 1986 reached 80 kBq for inhabitants of some settlements in the Bryansk region, 5-8 kBq in the Tula region and 5 kBq in the Orel region.
PubMed ID
14527038 View in PubMed
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131I dose to the human fetal thyroid in the Zagreb district, Yugoslavia, from the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature65399
Source
Int J Radiat Biol. 1988 Aug;54(2):167-77
Publication Type
Article
Date
Aug-1988
Author
M. Basic
B. Kasal
I. Simonovic
S. Jukic
Author Affiliation
Department of Nuclear Medicine, Clinical Hospital Centre-Rebro and Medical Faculty, Zagreb, Yugoslavia.
Source
Int J Radiat Biol. 1988 Aug;54(2):167-77
Date
Aug-1988
Language
English
Publication Type
Article
Keywords
Accidents
Female
Humans
Iodine Radioisotopes - metabolism
Maternal-Fetal Exchange
Nuclear Reactors
Pregnancy
Radiation Dosage
Radioactive fallout
Thyroid Gland - metabolism
Ukraine
Yugoslavia
Abstract
The 131I activity was measured in 30 human fetal thyroids in Zagreb district after the Chernobyl accident. A model of radioiodine metabolism in the mother and human fetus which takes into account the age dependence of the uptake and retention of radioiodine in the fetal thyroid was developed. Having assessed that the total intake by the average mother was about 1330 Bq, a good correlation between calculated and measured fetal thyroid activities was found (r = 0.77, P less than 0.001). The fetal thyroid dose reached the maximum of 0.43 micro Gy/Bq intake at about the fifth month of gestation. It was concluded that the risk of having a child with a harmful trait due to 131I absorbed by the mother was negligible.
PubMed ID
2900274 View in PubMed
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Age- and sex-specific relative thyroid radiation exposure to 131I in Ukraine after the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature32325
Source
Health Phys. 2001 Mar;80(3):242-50
Publication Type
Article
Date
Mar-2001
Author
W F Heidenreich
I. Kayro
M. Chepurny
P. Jacob
V. Spak
G M Goulko
H G Paretzke
Author Affiliation
GSF--Institut für Strahlenschutz, Neuherberg, Germany. heidenreich@gsf.de
Source
Health Phys. 2001 Mar;80(3):242-50
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Adult
Age Factors
Child
Child, Preschool
Dose-Response Relationship, Radiation
Environmental Exposure
Female
Humans
Infant
Iodine Radioisotopes - analysis - metabolism
Male
Middle Aged
Power Plants
Radiation Dosage
Research Support, Non-U.S. Gov't
Risk assessment
Sex Factors
Thyroid Gland - metabolism - radionuclide imaging
Ukraine
Abstract
The age- and sex-dependence of the 131I induced count rates is determined for the measurements performed in Ukraine after the Chernobyl accident on the thyroids of over 60,000 persons. For this, the individual measurements are scaled in such a way that the mean values over age and sex on one side and the mean values over measurement series on the other side are normalized to one. The resulting distribution of all scaled measurements is roughly log-normal. Half of them lie within a factor 1.6 of the median. 131I induced count rates have a minimum at birth year 1986, about half the value of adults. The maximum count rates with about 30% above adults are reached for males around age 16 y. The count rates are up to about 40% (at age 14-17 y) higher for males than for females. The results are within statistical uncertainties independent of the geographical area and the urban or rural nature of the settlements. Starting from the relative count rates, the age- and sex-dependence is calculated for the thyroid activities 1 mo after the accident for the integrated activities and for the doses. The dose of young children is a factor of about 6.5 higher than that of adults. Uncertainties are estimated throughout.
PubMed ID
11219536 View in PubMed
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Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study.

https://arctichealth.org/en/permalink/ahliterature140214
Source
Eur J Endocrinol. 2011 Jan;164(1):101-5
Publication Type
Article
Date
Jan-2011
Author
Bjørn Olav Asvold
Trine Bjøro
Lars J Vatten
Author Affiliation
Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, PO Box 8905 MTFS, N-7491 Trondheim, Norway. bjorn.o.asvold@ntnu.no
Source
Eur J Endocrinol. 2011 Jan;164(1):101-5
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Humans
Hypothyroidism - blood - complications - metabolism
Male
Middle Aged
Norway - epidemiology
Odds Ratio
Renal Insufficiency, Chronic - blood - epidemiology - etiology - metabolism
Risk factors
Thyroid Function Tests
Thyroid Gland - metabolism
Thyrotropin - blood
Abstract
Low thyroid function may be associated with reduced glomerular filtration rate (GFR). We therefore studied the association of thyroid function with estimated GFR (eGFR) in a population-based study.
A cross-sectional, population-based study of 29?480 individuals above 40 years of age, without previously known thyroid disease.
We calculated geometric mean eGFR and odds ratio (OR) of chronic kidney disease (CKD; eGFR
Notes
Erratum In: Eur J Endocrinol. 2011 Feb;164(2):316
PubMed ID
20930062 View in PubMed
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Does thyroid function influence fracture risk? Prospective data from the HUNT2 study, Norway.

https://arctichealth.org/en/permalink/ahliterature107290
Source
Eur J Endocrinol. 2013 Dec;169(6):845-52
Publication Type
Article
Date
Dec-2013
Author
Anders Svare
Tom Ivar Lund Nilsen
Bjørn Olav Asvold
Siri Forsmo
Berit Schei
Trine Bjøro
Arnulf Langhammer
Author Affiliation
Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.
Source
Eur J Endocrinol. 2013 Dec;169(6):845-52
Date
Dec-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Bone Density
Female
Follow-Up Studies
Fractures, Bone - blood - epidemiology - etiology - metabolism
Hip Fractures - blood - epidemiology
Humans
Incidence
Male
Middle Aged
Norway - epidemiology
Odds Ratio
Prospective Studies
Radius Fractures - blood - epidemiology
Registries
Risk
Thyroid Function Tests
Thyroid Gland - metabolism
Thyrotropin - blood
Ulna Fractures - blood - epidemiology
Abstract
To prospectively study the relation between TSH and risk of hip and forearm fractures.
A population-based cohort study.
In a substudy of the second survey of the Nord Trøndelag Health Study, Norway (HUNT2, 1995-97), linked with a hospital-based fracture registry, we investigated the relation between baseline TSH and risk of hip and/or forearm fractures.
A total of 16?610 women and 8595 men aged 40 years or more, without previous self-reported thyroid disease and hip or forearm fractures.
During 12.5 years follow-up, a total of 1870 women and 342 men experienced hip or forearm fractures. Overall, there was no relation between baseline TSH and fracture risk. However, there was weak evidence that women with TSH 3.5?mU/l had a slightly increased risk of hip fractures (hazard ratio (HR) 1.30, 95% CI 0.97-1.94 and HR 1.19, 95% CI 0.93-1.52) compared with the reference group with TSH of 1.5-2.4?mU/l. Supplementary analyses showed higher hip fracture risk in women with TSH >4.0?mU/l and negative thyroid peroxidase antibodies (TPOAb) compared with the reference group (HR 1.75, 95% CI 1.24-2.46).
We found no statistically significant relation between baseline TSH and subsequent fracture risk, but the data suggest a weak positive association with hip fracture risk among women with both low and high TSH. The latter association was confined to women with negative TPOAb status.
PubMed ID
24031093 View in PubMed
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Effect of lifelong iodine supplementation on thyroid 131-I uptake: a decrease in uptake in euthyroid but not hyperthyroid individuals compared to observations 50 years ago.

https://arctichealth.org/en/permalink/ahliterature172261
Source
Eur J Clin Nutr. 2006 Feb;60(2):210-3
Publication Type
Article
Date
Feb-2006
Author
M. Milakovic
G. Berg
R. Eggertsen
E. Nyström
Author Affiliation
Mölnlycke Primary Health Care and Research Centre, Department of Primary Health Care, Sahlgrenska Academy at Göteborg University, Sweden.
Source
Eur J Clin Nutr. 2006 Feb;60(2):210-3
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Aged
Female
Humans
Hyperthyroidism - metabolism - radionuclide imaging
Hypothyroidism - metabolism - radionuclide imaging
Iodine - administration & dosage - therapeutic use
Iodine Radioisotopes - metabolism
Male
Middle Aged
Radionuclide Imaging - methods
Sodium Chloride, Dietary - administration & dosage - therapeutic use
Sweden
Thyroid Gland - metabolism - radionuclide imaging
Time Factors
Abstract
In Sweden, iodine has been added to table salt (10 mg/kg) since 1936; this amount was increased in 1966 to 50 mg/kg.
To investigate a euthyroid Swedish population (n = 44, 60-65 years) with its entire lifespan with iodine supplementation as for 24-h 131-I uptake (24 h IU) and thyroid nodularity (thyroid scintigraphy). To compare the euthyroid 24 h IU with uptake of thyrotoxic individuals, and with observations from 1955.
The 24 h IU was used in euthyroid individuals after oral administration of 0.1 MBq/2.7 microCi radioiodine and imaging of the thyroid gland was carried out using 99mTc-pertechnetate.
In 1999-2000, the mean 24 h IU in the euthyroid individuals was 21% (range 11-33%) and the normal (central 95%) reference interval was 14-30%. Scintigraphy suggested multinodular goitre in three euthyroid individuals. In Graves' patients (n = 53, 50-65 years), the mean 24 h IU was 61% (range 29-89%). In 1955, the 24 h IU in euthyroid individuals was higher (38%, range 10-70%), while hyperthyroid patients had uptake values similar to those recorded in the present investigation (mean 62%, range 40-90%).
The population sample studied had to be small for ethical reasons. We conclude that the reference interval for 24 h IU is 14-30% in this population that had spent its entire lifespan with iodine supplementation. This is lower than that recorded in a Swedish euthyroid population half a century ago having had low-grade table-salt iodine supplementation for 20 years. Values for hyperthyroid patients, however, do not appear to have been affected likewise.
PubMed ID
16251883 View in PubMed
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[Effect of radio therapy on the magnitude of iodine radioisotope half-life in the thyroid tissue remnants in patients with differentiated thyroid cancer]

https://arctichealth.org/en/permalink/ahliterature89809
Source
Lik Sprava. 2008 Jul-Sep;(5-6):17-23
Publication Type
Article
Author
Kozak O V
Trembach O M
Romanenko L V
Butrym O I
Source
Lik Sprava. 2008 Jul-Sep;(5-6):17-23
Language
Ukrainian
Publication Type
Article
Keywords
Half-Life
Humans
Iodine Radioisotopes - administration & dosage - pharmacokinetics - therapeutic use
Lymph Node Excision
Lymphatic Metastasis
Radiotherapy - methods
Thyroid Gland - metabolism - pathology - radiation effects - surgery
Thyroid Neoplasms - pathology - radiotherapy - surgery
Thyroidectomy
Abstract
The use of external irradiation in the treatment of patients with differentiated thyroid cancer is still under consideration. The aim of the study was to compare Tef in the thyroid remnants in patients with and without external irradiation prior to radioiodine treatment. 70 patients with thyroid remnants after resection of thyroid and dissection of pathological lymph nodes were treated by I-131. Patients were divided into two groups: Group 1--with external irradiation (25-60 Gy)-21 patient, and Group 2--patients who did not received external irradiation prior to radioiodine treatment (49 patients). Activities administered ranged from 1000 to 4500 MBq. I-131 kinetics was followed daily during first 4 days after activity administration on the basis of mathematical analysis of scintigraphy. T(ef) was calculated under the assumption of exponential excretion of 131-I from remnants. It was shown that in Group 1 T(eff) = 3.87 +/- 2.5 days, in Group 2 T(eff) amounted to 2.9 +/- 2.2 days. Thus, external irradiation resulted in slowing down of 131-I excretion in thyroid remnants. The probability of the full remnants ablation after the first course of 131-I treatment (p) has been calculated. It was shown that p is higher in the Group 2 in every activity interval. Teff in sequential courses of 131-I treatment has been measured at the same patients. Thus, external irradiation influences in different way at the previously irradiated and not irradiated cells.
PubMed ID
19253734 View in PubMed
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Effects of a complex contaminant mixture on thyroid hormones in breeding hooded seal mothers and their pups.

https://arctichealth.org/en/permalink/ahliterature294790
Source
Environ Pollut. 2018 Sep; 240:10-16
Publication Type
Journal Article
Date
Sep-2018
Author
Randi Grønnestad
Gro D Villanger
Anuschka Polder
Kit M Kovacs
Christian Lydersen
Bjørn M Jenssen
Katrine Borgå
Author Affiliation
Department of Biosciences, University of Oslo, Oslo, Norway; Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
Source
Environ Pollut. 2018 Sep; 240:10-16
Date
Sep-2018
Language
English
Publication Type
Journal Article
Keywords
Animals
Breeding
Endocrine Disruptors - metabolism
Environmental monitoring
Female
Mothers
Polychlorinated Biphenyls - metabolism
Seals, Earless - blood
Thyroid Gland - metabolism
Thyroid Hormones - blood - metabolism
Thyroxine - blood
Abstract
There is a general lack of information on the possible effects of perfluoroalkyl substances (PFASs) on thyroid hormones (THs) in wildlife species. The effects of PFASs, which are known endocrine disruptors, on the TH homeostasis in hooded seals (Cystophora cristata) have yet to be investigated. Previously, correlations were found between plasma thyroid hormone (TH) concentrations in hooded seals, and organohalogen contaminants (OHCs) and hydroxyl (OH)-metabolites. Because animals are exposed to multiple contaminants simultaneously in nature, the effects of the complex contaminant mixtures that they accumulate should be assessed. Herein, we analyse relationships between plasma concentrations of multiple contaminants including protein-associated PFASs, hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) and lipid soluble OHCs and plasma concentrations of free and total THs, i.e. triiodothyronine (FT3, TT3) and thyroxine (FT4, TT4) in hooded seal mothers and their pups. The perfluoroalkyl carboxylates (PFCAs) were the most important predictors for FT3 concentrations and TT3:FT3 ratios in the mothers. The FT3 levels decreased with increasing PFCA levels, while the TT3:FT3 ratios increased. In the pups, hexachlorocyclohexanes (HCHs) were the most important predictors for TT3:FT3 ratios, increasing with increasing HCHs levels. Additionally, perfluoroalkyl sulfonates (PFSAs) and PFCAs were important predictors for FT4:FT3 ratios in hooded seal pups, and the ratio increased with increasing concentrations. The study suggests that PFASs contribute to thyroid disruption in hooded seals exposed to complex contaminant mixtures that include chlorinated and fluorinated organic compounds.
PubMed ID
29729564 View in PubMed
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Effects of radiation on the production of immunoglobulins in children subsequent to the Chernobyl disaster.

https://arctichealth.org/en/permalink/ahliterature35248
Source
Allergy Proc. 1995 Jul-Aug;16(4):185-93
Publication Type
Article
Author
L P Titov
G D Kharitonic
I E Gourmanchuk
S I Ignatenko
Author Affiliation
Belarus State Institute of Microbiology and Immunology, Minsk, Belarus.
Source
Allergy Proc. 1995 Jul-Aug;16(4):185-93
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Cesium Radioisotopes - metabolism
Child
Humans
Immune System - metabolism
Immunity - radiation effects
Immunoglobulins - biosynthesis - radiation effects
Iodine - metabolism
Iodine Radioisotopes
Power Plants
Thyroid Gland - metabolism
Time Factors
Ukraine
Abstract
Studies on the immediate and long-term effects of radiation on the B-system immunity of children who were affected by radiation after the Chernobyl disaster (from 1986-1992) are summarized in this paper. Complete clinical and immunological examination of more than 6000 children have been carried out. The dynamics of the immune system, with ongoing reactions of cell proliferation and differentiation, gene amplification, transcription, translation, biosynthesis and switching production of isotypes and subclasses of immunoglobulins, as well as specific and nonspecific (natural) antibodies, make it highly susceptible to the action of radiation in addition to other ecological factors. B-system of immunity (B-cel level, concentration of immunoglobulins-M, G, A, E; subclasses of IgG (IgG1-IgG4) in the serum and saliva, and the level of nonspecific heterophilic autoantibodies (RF, antithyroglobulin) were investigated in children of differing ages and sex living in the territories of the Republic of Belarus contaminated with radionuclides. Research showed decreased levels of B-cell and IgM and IgG isotopes 40-50 days after the disaster and increased levels of IgA immunoglobulins at that time. Long-term effects of low doses of radiation showed increased concentrations of IgM and IgG, correlating changes in the B-system of immunity with the level of 137Cs contamination in the territory of residence and also with the amount of 137Cs found in the children.
PubMed ID
8566726 View in PubMed
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[Evaluation of equivalent body burden in the thyroid for the people of Poland on results of 131I absorption after the disaster in Czernobyl. Determination of thyroid blockade with potassium iodide]

https://arctichealth.org/en/permalink/ahliterature37441
Source
Endokrynol Pol. 1991;42(2):189-202
Publication Type
Article
Date
1991
Author
P. Krajewski
Author Affiliation
Centralne Laboratorium Ochrony Radiologicznej.
Source
Endokrynol Pol. 1991;42(2):189-202
Date
1991
Language
Polish
Publication Type
Article
Keywords
Accidents, Radiation
Air Pollutants, Radioactive - analysis - pharmacokinetics
Body Burden
Child
Child, Preschool
English Abstract
Humans
Infant
Iodine Radioisotopes - analysis - pharmacokinetics
Maximum Allowable Concentration
Poland
Potassium Iodide - therapeutic use
Power Plants
Radiation Dosage
Thyroid Diseases - prevention & control
Thyroid Gland - metabolism - radiation effects
Ukraine
Abstract
An assessment of effectiveness of the administering of single dose of stable iodine in Poland on the reduction of 131I doses in thyroid has been performed. 5-compartment model of metabolism of iodine developed by Johnson has been used to evaluate predicted levels of stable iodine and 131I content in thyroid and commitment dose equivalent H50 for different doses of stable iodine and various age and sex group population. The measured values of 131I concentration in air and in milk and standard values for milk and food consumption and inhalation rate as well as metabolic parameters were used. Theoretical calculations showed that administering of stable iodine on 1986-04-28, 1986-04-29, 1986-04-30 and 1986-05-01 could have reduced committed dose equivalent H50 form ingestion with inhalation pathway by about 44%, 40%, 26%, 12% respectively. On the basis of measured 131I activity in the thyroid for inhabitants from different districts in Poland (1400 measurement) committed dose equivalents were determined and analysis of radiation hazard from 131I were performed. In the most contaminated regions of Poland average H50 doses for children 1-5 and 5-10 years old are close to 50 mSv (permissible level for population) and maximal doses exceed this limit four times. These maximal doses occurred for about from 5% inhabitants from these area. In the moderate and low contaminated regions of Poland the average doses are fivefold and tenfold less respectively.
PubMed ID
1364472 View in PubMed
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43 records – page 1 of 5.