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[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].

https://arctichealth.org/en/permalink/ahliterature122008
Source
Med Tr Prom Ekol. 2012;(5):41-8
Publication Type
Article
Date
2012
Author
A R Irmiakova
O V Kochetova
M K Gainullina
O V Sivochalova
T V Viktorova
Source
Med Tr Prom Ekol. 2012;(5):41-8
Date
2012
Language
Russian
Publication Type
Article
Keywords
Adult
Case-Control Studies
Chemical Industry
Cytochrome P-450 CYP1A1 - genetics
Cytochrome P-450 CYP1A2 - genetics
Female
Fibrocystic Breast Disease - enzymology - epidemiology - etiology - genetics
Gene Frequency
Genetic Predisposition to Disease
Homozygote
Humans
Leiomyoma - enzymology - epidemiology - etiology - genetics
Middle Aged
Occupational Exposure - adverse effects - analysis
Occupational Health
Petroleum Pollution - adverse effects - analysis
Polymorphism, Genetic
Regression Analysis
Russia
Thyroid Diseases - enzymology - epidemiology - etiology - genetics
Abstract
The article presents results obtained in study of relationship between polymorph variants of CYP1A1 and CYP1A2 genes with reproductive and thyroid diseases risk in female workers of petrochemical industry, when compared with reference group females. Variants TD and DD of CYP1A2 gene appeared to be associated with nodes formation in uterus and breast in female workers and reference group females. Following liability markers are obtained: homozygous in rare allele genotype CC of CYP1A1 gene for reproductive and thyroid diseaes (fibrous cystic mastopathy and nodular goitre), heterozygous genotype AG of CYP1A1 gene in uterine myoma and fibrous cystic mastopathy, homozygous in deleted T genotype of CYP1A2 gene in autoimmune thyroiditis. Occupational hazards and long length of service at hazardous industries increase effects of rare alleles of the genes studied.
PubMed ID
22855999 View in PubMed
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