Skip header and navigation

Refine By

93 records – page 1 of 10.

Thrombosis is associated with inferior survival in multiple myeloma.

https://arctichealth.org/en/permalink/ahliterature125151
Source
Haematologica. 2012 Oct;97(10):1603-7
Publication Type
Article
Date
Oct-2012
Author
Sigurdur Y Kristinsson
Ruth M Pfeiffer
Magnus Björkholm
Sam Schulman
Ola Landgren
Author Affiliation
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden. sigurdur.kristinsson@karolinska.se
Source
Haematologica. 2012 Oct;97(10):1603-7
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Female
Humans
Male
Multiple Myeloma - complications - mortality
Registries
Sweden
Thrombosis - etiology
Venous Thromboembolism - etiology
Abstract
Patients with multiple myeloma are at an increased risk of venous thromboembolism and arterial thrombosis. We assessed the impact of venous and arterial thrombosis on survival in a population-based study of 9,399 multiple myeloma patients diagnosed in Sweden from 1987 to 2005. We found multiple myeloma patients with venous thromboembolism to have a higher mortality at 1-, 5-, and 10-years of follow up compared with those without, with hazard ratios of 2.9 (95% confidence interval (CI) 2.4-3.5), 1.6 (95% CI: 1.5-1.8), and 1.6 (95% CI: 1.4-1.7), respectively. There was an increase in risk of death among multiple myeloma patients with arterial thrombosis, with hazard ratios of 3.4 (95% CI: 3.0-3.8), 2.2 (95% CI: 2.0-2.3), and 2.1 (95% CI: 1.9-2.1), respectively. In landmark analyses at six months, early arterial but not venous thromboembolism was associated with a higher risk of death. Thus, in contrast to prior smaller studies, we found the development of thrombosis to be associated with significantly poorer survival. The prevention of thrombosis in multiple myeloma is an important goal in the management of these patients.
Notes
Cites: N Engl J Med. 2007 Nov 22;357(21):2123-3218032762
Cites: Int J Cancer. 2007 Nov 15;121(10):2260-617583571
Cites: Blood. 2008 Nov 1;112(9):3582-618559977
Cites: J Clin Oncol. 2010 Jan 1;28(1):132-519901114
Cites: J Clin Oncol. 2010 Feb 10;28(5):830-420038719
Cites: Blood. 2010 Jun 17;115(24):4991-820299513
Cites: Blood. 2010 Jul 8;116(1):22-620339094
Cites: Blood. 2010 Dec 16;116(25):5501-620823456
Cites: Hematology Am Soc Hematol Educ Program. 2010;2010:437-4421239832
Cites: N Engl J Med. 2000 Dec 21;343(25):1846-5011117976
Cites: N Engl J Med. 2001 Jun 21;344(25):1951-211419443
Cites: Blood. 2002 Nov 1;100(9):3063-712384400
Cites: Clin Lymphoma. 2003 Jun;4(1):32-512837152
Cites: Haematologica. 2004 Jul;89(7):826-3115257934
Cites: N Engl J Med. 2004 Oct 28;351(18):1860-7315509819
Cites: Arch Intern Med. 1997 Aug 11-25;157(15):1665-709250227
Cites: J Clin Oncol. 2006 Jan 20;24(3):431-616365178
Cites: Blood. 2006 Jul 1;108(1):403; author reply 40416790586
Cites: Thromb Haemost. 2006 Dec;96(6):816-2117139378
Cites: Br J Haematol. 2007 May;137(3):268-917408469
Cites: J Thromb Haemost. 2007 Apr;5(4):692-917367492
Cites: J Clin Oncol. 2007 May 20;25(15):1993-917420512
Cites: Blood Coagul Fibrinolysis. 2007 Oct;18(7):595-817890944
Cites: Blood. 2008 Mar 1;111(5):2516-2017975015
PubMed ID
22511493 View in PubMed
Less detail

Thrombosis in a mechanical aortic valve prosthesis during subcutaneous heparin therapy in pregnancy; a case report.

https://arctichealth.org/en/permalink/ahliterature65184
Source
Eur J Obstet Gynecol Reprod Biol. 1990 Jul-Aug;36(1-2):175-7
Publication Type
Article
Author
J. Tapanainen
M. Ikäheimo
P. Jouppila
M L Kortelainen
P. Salmela
Author Affiliation
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Source
Eur J Obstet Gynecol Reprod Biol. 1990 Jul-Aug;36(1-2):175-7
Language
English
Publication Type
Article
Keywords
Adult
Aortic Valve
Female
Heart Valve Prosthesis - adverse effects
Heparin - therapeutic use
Humans
Pregnancy
Pregnancy Complications, Cardiovascular
Thrombosis - etiology
Abstract
Maternal death due to thrombosis in a mechanical aortic valve prosthesis during heparin therapy is described. The patient had a normal pregnancy during warfarin therapy. In this pregnancy, warfarin therapy was replaced by subcutaneous heparin injections, and the patient died of massive thrombosis in the valvuloprosthesis at 20 weeks of pregnancy. The effectiveness of heparin therapy and difficulties in the follow-up of heparin treatment during pregnancy are discussed.
PubMed ID
2365123 View in PubMed
Less detail

The blower: a useful tool to complete thrombectomy of the mechanical prosthetic valve.

https://arctichealth.org/en/permalink/ahliterature82390
Source
Ann Thorac Surg. 2006 May;81(5):1911-2
Publication Type
Article
Date
May-2006
Author
Aroussi Aziz Alami
Sami Ibrahim Mohamed
Leguerrier Alain
Verhoye Jean Phillippe
Author Affiliation
Department of Thoracic and Cardiovascular Surgery, University Hospital Ponchaillou, Rennes, France.
Source
Ann Thorac Surg. 2006 May;81(5):1911-2
Date
May-2006
Language
English
Publication Type
Article
Keywords
Aged
Heart Valve Diseases - surgery
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation - adverse effects
Humans
Male
Thrombectomy - instrumentation
Thrombosis - etiology - surgery
Abstract
Thrombectomy could be an excellent approach on one condition (ie, that all parts of the thrombus are removed). We propose to use a tool (ie, the blower) to complete thrombectomy of the prosthetic mechanical valve. The blower is a vaporizer that mixes air and heparinized saline with regulator of flow and proportion used in beating heart surgery. For thrombectomy, we have modified the air-water mixing part and intensity until we obtained a jet that enabled us to remove the micro thrombus that covered the prosthetic valve and surrounding tissues. The blower completely cleaned the prosthetic valve. With this tool, thrombectomy seems easier, more complete, and more reliable with the advantages of short cross-clamping time.
PubMed ID
16631711 View in PubMed
Less detail

Pathogenesis and morphogenesis of microcirculatory disorders in myocardial infarction. Clinical and ultrastructural examination.

https://arctichealth.org/en/permalink/ahliterature54706
Source
Pol J Pathol. 1996;47(1):27-32
Publication Type
Article
Date
1996
Author
J H Kiyak
D D Zerbino
Author Affiliation
Department of Therapy, Medical Institute, Lviv, Ukraine.
Source
Pol J Pathol. 1996;47(1):27-32
Date
1996
Language
English
Publication Type
Article
Keywords
Case-Control Studies
Coronary Circulation - physiology
Coronary Thrombosis - etiology - pathology
Female
Humans
Male
Microcirculation - ultrastructure
Middle Aged
Morphogenesis
Myocardial Infarction - complications - pathology
Abstract
Major advances in the understanding of myocardial infarction (MI) have been made on animal models of ischemia and infarction. We performed ultrastructural examinations of the hearts of 36 patients who died during the acute phase of MI. Tissue for investigation was obtained by express necropsy immediately after death at the clinic. All components of the microcirculatory system of the heart were damaged during the acute phase of MI. Coronary thrombosis led to arteriolar spasm and intravascular blood coagulation in the vicinity of the damaged artery. Microvessels reduction in ischemic, necrotic, and near-infarct zones was caused by endothelial cell injury and rheological disturbances. Thrombocytes played a decisive role in thrombus formation and arteriolar constriction. Leukocytes nearly always impaired the microhemodynamics in ischemic zones due to their size and rigidity. Microcirculatory disorders seemed to precede myocardial cell injury and death.
PubMed ID
8705266 View in PubMed
Less detail

[Prevention of a brain infarct in patients with non-rheumatic atrial fibrillation]

https://arctichealth.org/en/permalink/ahliterature55403
Source
Ned Tijdschr Geneeskd. 1989 Jul 29;133(30):1485-6
Publication Type
Article
Date
Jul-29-1989

[The clinical picture and pathogenesis of complications in food poisonings (salmonellosis)].

https://arctichealth.org/en/permalink/ahliterature212526
Source
Zh Mikrobiol Epidemiol Immunobiol. 1996 Mar-Apr;(2):95-7
Publication Type
Article
Author
L E Brodov
V V Maleev
N D Iushchuk
Source
Zh Mikrobiol Epidemiol Immunobiol. 1996 Mar-Apr;(2):95-7
Language
Russian
Publication Type
Article
Keywords
Acute Disease
Acute Kidney Injury - etiology
Humans
Moscow
Myocardial Infarction - etiology
Pneumonia - etiology
Respiratory Distress Syndrome, Adult - etiology
Salmonella Food Poisoning - complications - diagnosis
Thrombosis - etiology
Abstract
Observation on 32,448 salmonellosis patients was carried out. In 653 cases (2.01%) the complicated course of the disease was observed. It was caused by generalized disturbances in blood circulation, or shock, in 0.09% of cases, or by regional disturbances in blood circulation (myocardial infarction in 0.4%, acute disturbances in cerebral circulation in 0.4%, thrombosis of mesenterial vessels in 0.1% of cases). In addition, infectious complications developed in the form of pneumonia (0.5%) and acute renal insufficiency (0.6% of cases). Acute adrenal insufficiency, observed in the past, did not practically occur during the recent 20 years, having lost its importance due to the use of adequate therapy with polyionic crystalloid solutions.
PubMed ID
8701671 View in PubMed
Less detail

Clinical experience of arteriovenous fistulae for dialysis during an eighteen year period.

https://arctichealth.org/en/permalink/ahliterature233982
Source
Ann Chir Gynaecol. 1988;77(3):108-10
Publication Type
Article
Date
1988
Author
T. Sisto
H. Riekkinen
Author Affiliation
Department of Surgery, University Central Hospital, Tampere, Finland.
Source
Ann Chir Gynaecol. 1988;77(3):108-10
Date
1988
Language
English
Publication Type
Article
Keywords
Aneurysm - etiology
Arteriovenous Shunt, Surgical - adverse effects
Female
Finland
Humans
Kidney Failure, Chronic - therapy
Male
Middle Aged
Renal Dialysis
Surgical Wound Infection - etiology
Thrombosis - etiology
Abstract
382 Brescia-Cimino type arteriovenous fistulae were created for chronic haemodialysis. Success rate at the first attempt was 73.6% of 281 cases. The most common method of anastomosis was endtoside vein to artery type. Thrombosis was the most frequent complication, other miscellaneous complications were less common.
PubMed ID
3223729 View in PubMed
Less detail

Risk factors for venous thrombosis in Swedish children and adolescents.

https://arctichealth.org/en/permalink/ahliterature29449
Source
Acta Paediatr. 2005 Jun;94(6):717-22
Publication Type
Article
Date
Jun-2005
Author
Olof Rask
Erik Berntorp
Rolf Ljung
Author Affiliation
Department of Paediatrics, University Hospital, Malmö, Sweden. olof.rask@pediatrik.mas.lu.se
Source
Acta Paediatr. 2005 Jun;94(6):717-22
Date
Jun-2005
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Research Support, Non-U.S. Gov't
Retrospective Studies
Risk factors
Sweden - epidemiology
Venous Thrombosis - etiology - genetics
Abstract
AIM: To identify prothrombotic risk profiles in children and adolescents referred to a regional coagulation centre in southern Sweden for a first thrombotic event. METHODS: One hundred and twenty-eight consecutive children and adolescents (newborn to 20 y) referred for evaluations of a first episode of venous thrombosis were investigated. Clinical data were collected retrospectively, and the following variables were investigated: protein C, protein S, antithrombin; resistance to activated protein C; the genotypes FV-G1691A, F II-G20210A, MTHFR-C677T, MTHFR- A1298C; coagulation factors VIII and XI. RESULTS: 104/128 subjects (81%) had identifiable acquired risk factors, most often indwelling catheters and hormone therapy. Predisposing genetic factors related to thromboembolic events were revealed in 53/83 (64%) of subjects who agreed to follow-up blood sampling, and 17/83 (20%) had two or more inherited risk factors. Combinations of genetic and acquired risk factors were identified in 45/83 (54%) of the subjects, and 77/83 (93%) had at least one such risk factor. Both sexes had one peak in frequency at less than 1 y of age and then an increase during adolescence, more in females than in males. Plasma values for coagulation factors VIII and XI were age appropriate and showed a normal Gaussian distribution. CONCLUSION: This study identified prothrombotic risk profiles in almost all children and adolescents with venous thrombosis, which underlines the importance of careful evaluation of genetic and acquired risk factors.
PubMed ID
16188774 View in PubMed
Less detail

Dilated cardiomyopathy with recurrent intraventricular thrombosis.

https://arctichealth.org/en/permalink/ahliterature55119
Source
Jpn Heart J. 1992 Jul;33(4):487-91
Publication Type
Article
Date
Jul-1992
Author
Z. Arslan
T. Tezic
A. Akinci
I. Gur
E. Haspolat
S. Karademir
Author Affiliation
Department of Allergy, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
Source
Jpn Heart J. 1992 Jul;33(4):487-91
Date
Jul-1992
Language
English
Publication Type
Article
Keywords
Aspirin - therapeutic use
Cardiomyopathy, Dilated - complications - diagnosis - drug therapy
Coronary Thrombosis - etiology - prevention & control
Echocardiography
Electrocardiography
Heart Ventricles
Heparin - therapeutic use
Humans
Infant
Male
Radiography, Thoracic
Recurrence
Abstract
Dilated cardiomyopathy with intraventricular thrombosis is a rare disease, most frequently encountered in adults. It rarely occurs in infants. We report here the case of a 2-year-old boy with intraventricular thrombosis due to dilated cardiomyopathy and emphasize the importance of prophylactic anticoagulant therapy in this case.
PubMed ID
1453553 View in PubMed
Less detail

[Characteristic of fatal thrombotic complications based on the materials from the Thanatology Department of Forensic Medicine Bureau of the Rostov region, for 2004-2007].

https://arctichealth.org/en/permalink/ahliterature145982
Source
Sud Med Ekspert. 2009 Nov-Dec;52(6):3-7
Publication Type
Article
Author
D P Berezovskii
V V Kolkutin
V V Kovtunov
I V Kornienko
Source
Sud Med Ekspert. 2009 Nov-Dec;52(6):3-7
Language
Russian
Publication Type
Article
Keywords
Aged
Cities
Female
Forensic Pathology
Humans
Male
Middle Aged
Pulmonary Embolism - etiology - mortality - pathology
Russia
Sex Factors
Thanatology
Venous Thrombosis - etiology - mortality - pathology
Wounds and Injuries - complications
Abstract
The authors report statistical data on the spectrum and frequency of fatal thrombotic complications based on the analysis of materials available from the regional bureau of forensic medical examination collected in the period from 2004 to 2007. All lethal cases are categorized in terms of the patients' age, gender, time and clinical characteristics of the injury, time of surgical intervention. Results of the analysis indicate the necessity of examination of fatal cases of thrombotic complications following a standardized protocol.
PubMed ID
20088128 View in PubMed
Less detail

93 records – page 1 of 10.