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Alterations in T-lymphocyte subsets among Danish haemophiliacs: relation to source of factor VIII preparations and high dose factor VIII treatment.

https://arctichealth.org/en/permalink/ahliterature39856
Source
Scand J Haematol. 1984 May;32(5):544-51
Publication Type
Article
Date
May-1984
Author
J. Gerstoft
K. Bentsen
E. Scheibel
J. Dalsgård-Nielsen
J. Gormsen
E. Dickmeiss
Source
Scand J Haematol. 1984 May;32(5):544-51
Date
May-1984
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alanine Transaminase - metabolism
Antibodies, Viral - analysis
Child
Child, Preschool
Cytomegalovirus - isolation & purification
Denmark
Drug Industry
Europe
Factor VIII - therapeutic use
Hemophilia A - immunology
Humans
Immunoglobulin G - analysis
Infant
Liver - enzymology
Middle Aged
T-Lymphocytes, Helper-Inducer - classification
T-Lymphocytes, Regulatory - classification
United States
Abstract
Screening of 43 healthy Danish haemophiliacs revealed a significantly lower helper/suppressor (H/S) ratio than in controls. 8 of the haemophiliacs had an H/S ratio less than or equal to 1.0. A significant negative correlation occurred between the total lifetime factor VIII treatment and the H/S ratio. However, high-dose factor VIII treatment given to patients with antibodies against factor VIII was not associated with immunological abnormalities. Children had a significantly higher H/S ratio than the adult haemophiliacs. Patients exclusively treated with Danish cryoprecipitate during the last year had a significantly higher H/S ratio than patients receiving preparations from other sources. This difference might, however, be explained by lower age and lower total lifetime dose in the group receiving Danish preparations. Haemophiliacs treated with American preparations did not differ immunologically from those treated with preparations of other origin. Total serum IgG was increased in 23% of the patients. This parameter was negatively correlated with the H/S ratio. The possible relation of the observed immunological alterations among otherwise healthy haemophiliacs to the acquired immune deficiency syndrome warrants further attention.
PubMed ID
6328639 View in PubMed
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Low T-lymphocyte ratios in homosexual men. Epidemiologic evidence for a transmissible agent.

https://arctichealth.org/en/permalink/ahliterature240704
Source
JAMA. 1984 Mar 16;251(11):1441-6
Publication Type
Article
Date
Mar-16-1984
Author
R J Biggar
M. Melbye
P. Ebbesen
D L Mann
J J Goedert
R. Weinstock
D M Strong
W A Blattner
Source
JAMA. 1984 Mar 16;251(11):1441-6
Date
Mar-16-1984
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antibodies, Viral - analysis
Denmark
Homosexuality
Humans
Male
Middle Aged
Sexual Behavior
Substance-Related Disorders - epidemiology
T-Lymphocytes - classification - immunology
T-Lymphocytes, Helper-Inducer - classification
T-Lymphocytes, Regulatory - classification
Travel
United States
Abstract
To investigate risk factors for immunologic abnormalities among homosexual men, T-lymphocyte helper/suppressor (OKT4/OKT8) ratios were determined in 78 healthy Danish homosexual men. Ratios in 26 men (33%) were low (less than 1.00). Visiting the United States in 1980 to 1981 was a strong (7.7-fold) risk factor for having a ratio less than 1.00. Among nine travelers who visited only once, the risk of having a low ratio increased significantly if the visit had occurred in 1981. A risk of similar magnitude (6.9-fold) was found among the three men who had not been to the United States but who reported homosexual contact with a Danish man who became ill with Kaposi's sarcoma. Risk of low ratios did not correlate with age or years of homosexual activity. Promiscuity was not a significant risk factor, but these men generally had fewer sex partners than that which has been reported from the United States. Neither nitrite inhalant use nor cytomegalovirus antibody (prevalence or titer) was associated with low ratios. These data support the hypothesis that a transmissible biologic agent may be etiologically responsible for the low helper/suppressor ratios in homosexual men.
PubMed ID
6230466 View in PubMed
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