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Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden.

https://arctichealth.org/en/permalink/ahliterature20782
Source
Int J Cancer. 1999 Nov 26;83(5):585-90
Publication Type
Article
Date
Nov-26-1999
Author
V. Chajès
K. Hultén
A L Van Kappel
A. Winkvist
R. Kaaks
G. Hallmans
P. Lenner
E. Riboli
Author Affiliation
Laboratoire de Biologie des Tumeurs, E.A. 2103, Unité de Recherche Associée Université-INRA, Faculté de Médecine, Tours, France.
Source
Int J Cancer. 1999 Nov 26;83(5):585-90
Date
Nov-26-1999
Language
English
Publication Type
Article
Keywords
Breast Neoplasms - blood - chemistry - epidemiology
Case-Control Studies
Fatty Acids, Unsaturated - analysis - blood
Female
Humans
Incidence
Middle Aged
Palmitic Acid - analysis - blood
Phospholipids - blood - chemistry
Prospective Studies
Risk
Stearic Acids - analysis - blood
Sweden - epidemiology
Abstract
The study of the relationship between dietary intake of fatty acids and the risk of breast cancer has not yielded definite conclusions with respect to causality, possibly because of methodological issues inherent to nutritional epidemiology. To evaluate the hypothesis of possible protection of n-3 polyunsaturated fatty acids (PUFA) against breast cancer in women, we examined the fatty-acid composition of phospholipids in pre-diagnostic sera of 196 women who developed breast cancer, and of 388 controls matched for age at recruitment and duration of follow-up, in a prospective cohort study in Umeâ, northern Sweden. Individual fatty acids were measured as a percentage of total fatty acids, using capillary gas chromatography. Conditional logistic-regression models showed no significant association between n-3 PUFA and breast-cancer risk. In contrast, women in the highest quartile of stearic acid had a relative risk of 0.49 (95% confidence interval, 0.22-1.08) compared with women in the lowest quartile (trend p = 0.047), suggesting a protective role of stearic acid in breast-cancer risk. Besides stearic acid, women in the highest quartile of the 18:0/18:1 n-9c ratio had a relative risk of 0.50 (95% confidence interval, 0.23-1.10) compared with women in the lowest quartile (trend p = 0.064), suggesting a decrease in breast-cancer risk in women with low activity of the enzyme delta 9-desaturase (stearoyl CoA desaturase), which may reflect an underlying metabolic profile characterized by insulin resistance and chronic hyper-insulinemia.
PubMed ID
10521790 View in PubMed
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