Skip header and navigation

2 records – page 1 of 1.

Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.

https://arctichealth.org/en/permalink/ahliterature18997
Source
Bull Exp Biol Med. 2002 Apr;133(4):392-5
Publication Type
Article
Date
Apr-2002
Author
T A Korolenko
S Ya Zhyanaeva
O N Poteryaeva
O V Falameeva
O A Levina
V I Kaledin
I. Shandula
Author Affiliation
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. T.A.Korolenko@iph.ma.ru
Source
Bull Exp Biol Med. 2002 Apr;133(4):392-5
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Animals
Carcinoma, Lewis Lung - enzymology - pathology
Cathepsin B - metabolism
Liver - enzymology
Lymphoma, Diffuse - enzymology - pathology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Prognosis
Spleen - enzymology
Tumor Markers, Biological - metabolism
Abstract
We measured activity and content of cathepsin B in tumor tissues, liver, and spleen in mice with Lewis adenocarcinoma and LS-lymphosarcoma. Cathepsin B activity in Lewis adenocarcinoma cells was lower than in LS-lymphosarcoma cells, which was probably related to differences in their metastatic properties. Antitumor therapy increased activity and content of cathepsin B in tumor tissues. Changes in the content and activity of cathepsin B in tumor tissues can serve as a prognostic criterion for tumor regression during therapy. Cathepsin B is probably involved in apoptosis of tumor cells during chemotherapy of lymphosarcoma-LS with cyclophosphamide.
PubMed ID
12124655 View in PubMed
Less detail

[Isoenzymic composition of glucose-6-phosphate dehydrogenase of subcellular fractions of rabbit tissues under alloxan diabetes]

https://arctichealth.org/en/permalink/ahliterature49029
Source
Ukr Biokhim Zh. 1975 May-Jun;47(3):339-41
Publication Type
Article
Author
N M Hula
Ia L Hermaniuk
Source
Ukr Biokhim Zh. 1975 May-Jun;47(3):339-41
Language
Ukrainian
Publication Type
Article
Keywords
Adrenal Glands - enzymology
Animals
Cytoplasm - enzymology
Diabetes Mellitus, Experimental - enzymology
English Abstract
Glucosephosphate Dehydrogenase - metabolism
Isoenzymes - metabolism
Liver - enzymology
Mitochondria - enzymology
Mitochondria, Liver - enzymology
Mitochondria, Muscle - enzymology
Muscles - enzymology
Myocardium - enzymology
Rabbits
Spleen - enzymology
Subcellular Fractions - enzymology
Abstract
The isoenzymes of glucose-6-phosphate dehydrogenase (G-6-PD, EC 1.1.1.49) was studied in hyaloplasm and mitochondria of the liver, myocardium, skeletal muscle, spleen and adrenals of alloxan diabetic rabbits. The most significant changes were found in the liver hyaloplasm: one of the minor isoenzymes, isoenzyme "C", disappears and the zone of the main isoenzyme "E" decreases significantly in comparison with the control. It was found that the intensity of these changes depends on the glycemia level in the diabetic animals.
PubMed ID
1216350 View in PubMed
Less detail