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132 records – page 1 of 14.

2-hydroxypropyl-Ã?-cyclodextrin in eye drops: Evaluation in human patients

https://arctichealth.org/en/permalink/ahliterature102117
Source
Pages 55-57 in G. Pétursdóttir et al., eds. Circumpolar Health 93. Proceedings of the 9th International Congress on Circumpolar Health, Reykjavík, Iceland, June 20-25, 1993. Arctic Medical Research. 1994;53(Suppl.2)
Publication Type
Article
Date
1994
~hthalmology and 2 Department of Pharmacy, Faculty of Medicine, University of Iceland, Reykjavfk. 3 Landakot Hospital department of Ophthalmology, Reykjavik, Iceland. 4 Lyfjaverslun nldsins, Reykjavik, Iceland. Abstract: Cyclodextrins facilitate the solubility of hydrophobic compounds in aqueous solutions
  1 document  
Author
Thórisdóttir, S
Stefánsson, E
Loftsson, Th.
Guðmundsson, �G
Friðriksdóttir, H
Guðmundsson, �,
Sigthórsson, Th
Thorisdottir, S
Stefansson, E
Guomundsson, O.G.
Frioriksdottir, H
Guomundsson, O
Sigthorsson, Th
Author Affiliation
Department of Ophthalmology, University of Iceland, Reykjavik
Department of Pharmacy, University of Iceland, Reykjavik
Landakot Hospital Dept. of Ophthalmology, Reykjavik, Iceland
Lyfjaverslun ríkisins, Reykjavik, Iceland
Source
Pages 55-57 in G. Pétursdóttir et al., eds. Circumpolar Health 93. Proceedings of the 9th International Congress on Circumpolar Health, Reykjavík, Iceland, June 20-25, 1993. Arctic Medical Research. 1994;53(Suppl.2)
Date
1994
Language
English
Publication Type
Article
Digital File Format
Text - PDF
Keywords
2-hydroxypropyl-Ã?-cyclodextrin
aqueous eye drops
artificial tear solution
cyclodextrin
dry eyes
hydrophobic drugs
Lipids
ophthalmic formulation
Solubility
toxicity
Abstract
Cyclodextrins facilitate the solubility of hydrophobic compounds in aqueous solutions. This allows the use of hydrophobic drugs and lipids in aqueous eye drops containing cyclodextrin. This study examines the possible toxicity of an eye drop preparation that contains 2-hydroxypropyl-Ã?-cyclodextrin and its possible efficacy as a lubricant in patients with dry eyes. Artificial tear solution that contains a lipid (cholesterol), an oligosaccharide (2-hydroxypropyl-Ã?-cyclodextrin) and saline was produced to mimic the natural tear film of the eye. The toxicity and usefulness of this drug was studied in rabbits and humans. The results demonstrate that the cyclodextrin-cholesterol artificial tear solution is well tolerated by the rabbit and human eye and is not toxic. It had therapeutic value in people with mild dryness of eyes, while those with severe dryness found no beneficial effect.
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238Pu: accumulation, tissue distribution, and excretion in Mayak workers after exposure to plutonium aerosols.

https://arctichealth.org/en/permalink/ahliterature126152
Source
Health Phys. 2012 Mar;102(3):243-50
Publication Type
Article
Date
Mar-2012
Author
Klara G Suslova
Alexandra B Sokolova
Viktor V Khokhryakov
Scott C Miller
Author Affiliation
Southern Urals Biophysics Institute (SUBI), Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia. suslova@subi.su
Source
Health Phys. 2012 Mar;102(3):243-50
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Aerosols
Bone and Bones - metabolism - radiation effects
Health Physics
Humans
Liver - metabolism - radiation effects
Lung - metabolism - radiation effects
Occupational Exposure
Plutonium - administration & dosage - pharmacokinetics - toxicity - urine
Russia
Solubility
Tissue Distribution
Abstract
The alpha spectrometry measurements of specific activity of 238Pu and 239Pu in urine from bioassay examinations of 1,013 workers employed at the radiochemical and plutonium production facilities of the Mayak Production Association and in autopsy specimens of lung, liver, and skeleton from 85 former nuclear workers who died between 1974-2009, are summarized.The accumulation fraction of 238Pu in the body and excreta has not changed with time in workers involved in production of weapons-grade plutonium production (e.g., the plutonium production facility and the former radiochemical facility). The accumulation fraction of 238Pu in individuals exposed to plutonium isotopes at the newer Spent Nuclear Fuel Reprocessing Plant ranged from 0.13% up to 27.5% based on the autopsy data. No statistically significant differences between 238Pu and 239Pu in distribution by the main organs of plutonium deposition were found in the Mayak workers. Based on the bioassay data,the fraction of 238Pu activity in urine is on average 38-69% of the total activity of 238Pu and 239Pu, which correlates with the isotopic composition in workplace air sampled at the Spent Nuclear Fuel Reprocessing Plant. In view of the higher specific activity of 238Pu, the contribution of 238Pu to the total internal dose, particularly in the skeleton and liver, might be expected to continue to increase, and continued surveillance is recommended.
PubMed ID
22420016 View in PubMed
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[A method of isolating the main outer membrane protein of Chlamydia]

https://arctichealth.org/en/permalink/ahliterature57559
Source
Mikrobiol Z. 1998 May-Jun;60(3):85-90
Publication Type
Article
Author
O P Bilozorov
Author Affiliation
Ukrainian Research Institute of Dermatology and Venerology, Ministry of Health of Ukraine, Kharkiv.
Source
Mikrobiol Z. 1998 May-Jun;60(3):85-90
Language
Russian
Publication Type
Article
Keywords
Animals
Antibodies, Bacterial - analysis
Bacterial Outer Membrane Proteins - analysis - immunology - isolation & purification
Chick Embryo
Chlamydia trachomatis - immunology
Culture Media
English Abstract
Fluorescent Antibody Technique
Immune Sera - isolation & purification
Immunization
Immunoenzyme Techniques
Rabbits
Solubility
Abstract
Purified chlamydial bodies were solubilized by detergent solutions used in the following sequence: 1) 1% sarcosil, 2) 1% sarcosil + 10 mM dithiotreitol, 3) 2% sodium dodecyl sulfate + 10 mM dithiotreitol. After the third stage a good yield of protein, corresponding to major outer membrane protein as to its molecular weight and antigenic properties was obtained.
PubMed ID
9785804 View in PubMed
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[An assessment of the permissible level of a mixture of radionuclides from the Chernobyl fallout in human lungs]

https://arctichealth.org/en/permalink/ahliterature73504
Source
Radiobiologiia. 1992 Mar-Apr;32(2):163-71
Publication Type
Article
Author
A K Sukhoruchkin
Source
Radiobiologiia. 1992 Mar-Apr;32(2):163-71
Language
Russian
Publication Type
Article
Keywords
Accidents
Aerosols
Air Pollutants, Radioactive - adverse effects - analysis
English Abstract
Female
Health Physics
Humans
Lung - radiation effects
Male
Maximum Allowable Concentration
Nuclear Reactors
Power Plants
Radiation Dosage
Radioactive Fallout - adverse effects - analysis
Radioisotopes - adverse effects - analysis
Solubility
Ukraine
Abstract
The permissible level of a radionuclide mixture, resulted from the Chernobyl burst, in the human being lungs was determined for two kinds of compounds: absolutely insoluble compounds and soluble compounds in the state of equilibrium. For this purpose the data were used concerning the radionuclide composition and aerosol disperse in lower atmosphere which were obtained by the Department for Dosimetric Control (NPO "Pripiat'"). The results of measurements of 137Cs content taken by the use of human radiation spectrometer (HRS) needed an adequate estimation: low level of 137Cs in the human lungs and body within the Chernobyl NPP, zone does not guarantee radiation security. The notion "permissible content" and the possibility of using thereof in the individual dosimetric control are discussed.
PubMed ID
1598388 View in PubMed
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Application of ALOGPS 2.1 to predict log D distribution coefficient for Pfizer proprietary compounds.

https://arctichealth.org/en/permalink/ahliterature9356
Source
J Med Chem. 2004 Nov 4;47(23):5601-4
Publication Type
Article
Date
Nov-4-2004
Author
Igor V Tetko
Gennadiy I Poda
Author Affiliation
Biomedical Department, Institute of Bioorganic and Petroleum Chemistry, Ukrainian Academy of Sciences, Murmanskaya 1, Kyiv, 02094, Ukraine. itetko@vcclab.org
Source
J Med Chem. 2004 Nov 4;47(23):5601-4
Date
Nov-4-2004
Language
English
Publication Type
Article
Keywords
1-Octanol
Administration, Oral
Biological Availability
Chemistry, Pharmaceutical
Databases, Factual
Drug Design
Drug Industry
Hydrogen-Ion Concentration
Neural Networks (Computer)
Pharmaceutical Preparations - chemistry - metabolism
Private Sector
Quantitative Structure-Activity Relationship
Research Support, Non-U.S. Gov't
Software
Solubility
Water
Abstract
Evaluation of the ALOGPS, ACD Labs LogD, and PALLAS PrologD suites to calculate the log D distribution coefficient resulted in high root-mean-squared error (RMSE) of 1.0-1.5 log for two in-house Pfizer's log D data sets of 17,861 and 640 compounds. Inaccuracy in log P prediction was the limiting factor for the overall log D estimation by these algorithms. The self-learning feature of the ALOGPS (LIBRARY mode) remarkably improved the accuracy in log D prediction, and an rmse of 0.64-0.65 was calculated for both data sets.
PubMed ID
15509156 View in PubMed
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Assessment of androgenicity in leachates from Swedish landfills and treatments for its elimination.

https://arctichealth.org/en/permalink/ahliterature177513
Source
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2004;39(11-12):2817-25
Publication Type
Article
Date
2004
Author
Anders Svenson
Ann-Sofie Allard
Christian Junestedt
Olof Cerne
Mats Ek
Author Affiliation
IVL, Swedish Environmental Research Institute, Stockholm, Sweden. anders.svenson@ivl.se
Source
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2004;39(11-12):2817-25
Date
2004
Language
English
Publication Type
Article
Keywords
Humans
Industrial Waste
Receptors, Androgen - drug effects
Refuse Disposal
Soil Pollutants - toxicity
Solubility
Sweden
Toxicity Tests
Transfection
Water Pollutants - toxicity
Yeasts - genetics
Abstract
An in vitro recombinant yeast strain, transfected with the human androgen receptor was used to assess androgenic hormone disrupting potencies in leachates from Swedish landfills. It was shown that components in extracts of these affected the androgenic receptor and promoted a response in the beta-galactosidase marker system. Levels were within the range of those determined for domestic sewage effluents but lower than the highest levels found in an industrial effluent. These leachates finally enter receiving waters with or without wastewater treatment. Evidence was found for transformation during some of the wastewater treatments.
PubMed ID
15533006 View in PubMed
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Association of CD44 isoform immunohistochemical expression with myometrial and vascular invasion in endometrioid endometrial carcinoma.

https://arctichealth.org/en/permalink/ahliterature3943
Source
Gynecol Oncol. 2002 Jan;84(1):58-61
Publication Type
Article
Date
Jan-2002
Author
Gary N Stokes
Jack B Shelton
Christopher M Zahn
Brian S Kendall
Author Affiliation
Department of Pathology, Third Medical Group, Elmendorf AFB, Alaska 99506, USA.
Source
Gynecol Oncol. 2002 Jan;84(1):58-61
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Antigens, CD44 - biosynthesis
Carcinoma, Endometrioid - blood supply - metabolism - pathology
Endometrial Neoplasms - blood supply - metabolism - pathology
Female
Glycoproteins - biosynthesis
Humans
Immunohistochemistry
Myometrium - pathology
Neoplasm Invasiveness
Neovascularization, Pathologic - metabolism
Protein Isoforms
Solubility
Abstract
OBJECTIVE: Appropriate clinical management of cases of FIGO Grade I and II endometrial carcinoma relies heavily on the determination of myometrial invasion (MI). There are no reports addressing expression of the cell adhesion molecule CD44 in the subset of Grade I and II endometrioid carcinoma (EC) as it relates to prognosis, including MI. METHODS: Immunohistochemical staining for CD44s and CD44v6 was evaluated in 40 hysterectomy specimens with Grade I and II EC, including 11 noninvasive ECs, 14 with MI 50%). Staining characteristics according to the presence of MI and vascular space invasion (VSI) were evaluated. Strong membranous staining of >10% of tumor cells was interpreted as positive. RESULTS: CD44v6 staining was positive in 20% (8/40) of cases, including 45% (5/11) of EC without MI but only 10% (3/29) with MI (P = 0.025). CD44v6 staining was not present in deeply invasive tumors (0/15), while it was present in 8/25 superficially or noninvasive tumors (P = 0.016). Sensitivity and specificity were 25 and 100%, respectively, using CD44v6 in evaluating deep myometrial invasion. CD44s showed a trend toward positive staining when comparing noninvasive versus invasive tumors and noninvasive/superficially invasive versus deeply invasive tumors (P = 0.08 and 0.12, respectively). CD44s or CD44v6 staining was highly specific for absence of VSI, although statistical comparison did not reach significance. CONCLUSION: Deeply invasive EC was associated with a consistent lack of CD44v6 expression. This may have potential clinical utility if this finding is demonstrated in further study of prehysterectomy sampling specimens containing EC.
PubMed ID
11748977 View in PubMed
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Bioavailability of elemental iron powders to rats is less than bakery-grade ferrous sulfate and predicted by iron solubility and particle surface area.

https://arctichealth.org/en/permalink/ahliterature61593
Source
J Nutr. 2003 Nov;133(11):3546-52
Publication Type
Article
Date
Nov-2003
Author
James H Swain
Samuel M Newman
Janet R Hunt
Author Affiliation
U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA.
Source
J Nutr. 2003 Nov;133(11):3546-52
Date
Nov-2003
Language
English
Publication Type
Article
Keywords
Animals
Biological Availability
Diet
Ferrous Compounds - chemistry - pharmacokinetics
Food Handling
Hemoglobins - metabolism
Iron - chemistry - pharmacokinetics
Male
Microscopy, Electron, Scanning
Powders
Rats
Rats, Sprague-Dawley
Regression Analysis
Research Support, U.S. Gov't, Non-P.H.S.
Solubility
Surface Properties
Abstract
Foods are fortified with elemental forms of iron to reduce iron deficiency. However, the nutritional efficacy of current, commercially produced elemental iron powders has not been verified. We determined the bioavailability of six commercial elemental iron powders and examined how physicochemistry influences bioavailability. Relative biological value (RBV) of the iron powders was determined using a hemoglobin repletion/slope ratio method, treating iron-deficient rats with repletion diets fortified with graded quantities of iron powders, bakery-grade ferrous sulfate or no added iron. Iron powders were assessed physicochemically by measuring iron solubility in hydrochloric acid at pH 1.0 and 1.7, surface area by nitrogen gas adsorption and surface microstructure by electron microscopy. Bioavailability from the iron powders, based on absolute iron intake, was significantly less than from FeSO4 (100%; P Electrolytic (54%; A-131, U.S.) > Electrolytic (46%; Electrolytic Iron, India) > H-Reduced (42%; AC-325, U.S.) > Reduced (24%; ATOMET 95SP, Canada) > CO-Reduced (21%; RSI-325, Sweden). Solubility testing of the iron powders resulted in different relative rankings and better RBV predictability with increasing time at pH 1.7 (R2 = 0.65 at 150 min). The prediction was improved with less time and lower pH (R2 = 0.82, pH 1.0 at 30 min). Surface area, ranging from 90 to 370 m2/kg, was also highly predictive of RBV (R2 = 0.80). Bioavailability of iron powders is less than bakery-grade ferrous sulfate and varies up to three times among different commercial forms. Solubility at pH 1.0 and surface area were predictive of iron bioavailability in rats.
PubMed ID
14608072 View in PubMed
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132 records – page 1 of 14.