To determine if sinusitis is associated with arterial hypertension in the Canadian population.
Complex survey design incorporating stratification, multiple stages of selection, and unequal probabilities of selection of respondents. Cross-sectional data from 52,992 subjects (25,324 males and 27,668 females) 20-64 years of age who participated in the second cycle of the National Population Health Survey (NPHS), conducted in 1996-1997. All these individuals were asked if they had certain chronic health conditions, that had lasted or were expected to last 6 months or more, including sinusitis and high blood pressure.
Overall, males with sinusitis were just over 2% more likely to have hypertension (9.3% vs. 7.1%) whereas the difference was 4% for women (11.8% vs. 7.6%). Adjusted for age, region, habitation, immigrant status, household size, number of bedrooms, income adequacy, education level, smoking status, alcohol consumption, regular exercise and body mass index, the adjusted odds ratio for females was 1.42 (95% CI 1.04, 1.95).
Reported sinusitis is associated with hypertension but only in women. Mechanisms linking upper respiratory disorders to hypertension merit investigation.
Previous studies have shown that cystic fibrosis (CF) gene mutations are linked to several severe chronic infections. Chronic sinusitis is one condition that may well be influenced by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. We studied two prevalent CF mutations (AF508 and 394delTT) in a population with a low incidence of CF. The carrier frequency of the CF mutations in the Finnish population is approximately 1 in 80. We examined DNA specimens from 127 chronic sinusitis patients and found one patient who was heterozygous for 394delTT gene mutation. None of the DNA specimens had any AF508 mutation. This study shows that in a population with a low incidence of CF there was no abnormal carrier distribution of the two most common CF gene mutations in a group of chronic sinusitis patients. Routine screening of sinusitis patients for CF mutations provides no additional information on the etiology of chronic sinusitis.
The number of patients hospitalized for acute infection in the frontal sinuses at the Department of Oto-Rhino-Laryngology of Turku University Hospital has increased markedly during the last decade. Causes for this increase were evaluated by comparing the backgrounds and medical findings of the 134 patients treated in the years 1977-81 and those of the 421 patients treated in the years 1982-86. Nasal polyps and history of allergic rhinitis were considerably more common in the latter patient group. The disease also seems to recur increasingly in the same patients. Of the aerobic bacteria Streptococcus pneumoniae and Haemophilus influenzae were the most common pathogens and the share of H. influenzae increased slightly, becoming the commonest pathogen in the latter 5-year period. Increasing air pollution in the city area of Turku is worth consideration and should be investigated further.
To determine the effect on patients' quality of life of functional endoscopic sinus surgery performed for chronic rhinosinusitis within a tertiary care centre in Montreal, Canada.
A prospective cohort study was undertaken. Subjects were consecutive patients with a diagnosis of chronic rhinosinusitis who had failed medical treatment and were undergoing functional endoscopic sinus surgery. Questionnaires assessing general health outcomes (i.e. the second version of the Short Form 12 questionnaire) and disease-specific outcomes (i.e. the Chronic Sinusitis Survey) were completed pre-operatively and a minimum of three months post-operatively.
A total of 152 patients were enrolled over a seven-month period, of whom 120 completed the post-operative surveys. The most common co-morbidity was asthma (40 per cent). Of the 120 patients with completed questionnaires, 72 per cent reported clinical improvement, 12 per cent reported deterioration and 15 per cent remained unchanged. The average improvement in Chronic Sinusitis Survey score was 17 per cent.
Patients with chronic rhinosinusitis achieved a significant improvement in disease-specific quality of life after functional endoscopic sinus surgery. There was no significant improvement in general health related quality of life, as measured using the Short Form 12 questionnaire.
Questionnaire distribution among ENT specialist's examinees was employed to study the prevalence of polypous rhynosinusitis in urban and rural population of the Kalinin region (organized groups of preschool and school children, industrial workers, medical students, district outpatients, collective farmers). Out of 6748 examinees the disease was registered in 89 (1.3%), the incidence rate being higher for men (2.3:1) and rural population (1.14 and 5.6%). In urban examinees polypous rhinosinusitis prevailed in workers (3.5%) followed by office workers (1.3%), students (0.2%) and schoolchildren (0.1%). The results obtained necessitate further study of etiopathogenesis and development of prophylactic measures for this disease, in the first place in industry and agriculture.
