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46 records – page 1 of 5.

5-HT(1A) receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats.

https://arctichealth.org/en/permalink/ahliterature9998
Source
Neurosci Lett. 2002 Mar 29;322(1):1-4
Publication Type
Article
Date
Mar-29-2002
Author
Nina K Popova
Elena A Ivanova
Author Affiliation
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia. npopova@bionet.nsc.ru
Source
Neurosci Lett. 2002 Mar 29;322(1):1-4
Date
Mar-29-2002
Language
English
Publication Type
Article
Keywords
Acute Disease
Alcohol-Induced Disorders, Nervous System - drug therapy - metabolism - physiopathology
Aminopyridines - pharmacology
Animals
Brain - drug effects - metabolism - physiopathology
Dose-Response Relationship, Drug
Drug Interactions - physiology
Drug Tolerance - physiology
Ethanol - pharmacology
Hypothermia - chemically induced - drug therapy - physiopathology
Male
Mice
Mice, Inbred C3H
Neurons - drug effects - metabolism
Piperazines - pharmacology
Rats
Rats, Wistar
Receptors, Serotonin - drug effects - metabolism
Receptors, Serotonin, 5-HT1
Research Support, Non-U.S. Gov't
Serotonin - metabolism
Serotonin Antagonists - pharmacology
Sleep - drug effects - physiology
Startle Reaction - drug effects - physiology
Abstract
The effect of a selective 5-HT(1A) antagonist, 4-(2'-methoxy-)phenyl-1-[2'-(N-2"-pyridinyl)-p-iodobenzamino-]ethyl-piperazine (p-MPPI), on acute ethanol-induced hypothermia, sleep and suppression of acoustic startle reflex in C3H/He mice and Wistar rats was studied. Administration of p-MPPI at the doses of 0.4, 0.7 and 1.0 mg/kg reduced in a dose-dependent manner the ethanol-induced hypothermia and the sleep time and attenuated the ethanol-induced decrease of acoustic startle reflex magnitude in mice. Similar p-MPPI (0.4 mg/kg) effects on ethanol-induced sleep and hypothermia were obtained in rats. It was concluded that 5-HT(1A) receptors were involved in the mechanisms of the ethanol-induced hypothermia and sleep, and that 5-HT(1A) antagonist increased acute ethanol tolerance.
PubMed ID
11958829 View in PubMed
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Alterations in intracellular reactive oxygen species generation and redox potential modulate mast cell function.

https://arctichealth.org/en/permalink/ahliterature14273
Source
Eur J Immunol. 1997 Jan;27(1):297-306
Publication Type
Article
Date
Jan-1997
Author
K. Wolfreys
D B Oliveira
Author Affiliation
Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, GB.
Source
Eur J Immunol. 1997 Jan;27(1):297-306
Date
Jan-1997
Language
English
Publication Type
Article
Keywords
Animals
Catalase - pharmacology
Cell Survival
Deferoxamine - pharmacology
Glutathione - metabolism
Hydrogen Peroxide - pharmacology
Mast Cells - physiology
Oxidation-Reduction
Peritoneal Cavity - cytology
Rats
Reactive Oxygen Species - metabolism
Research Support, Non-U.S. Gov't
Serotonin - metabolism
Spleen - cytology
Sulfhydryl Reagents - pharmacology
Abstract
The administration of mercuric chloride (HgCl2), gold compounds, or D-penicillamine to Brown Norway (BN) rats causes a T helper (Th)2 cell-associated autoimmune syndrome characterized by the production of a number of autoantibodies, marked elevation of serum IgE concentration, and tissue injury in the form of a vasculitis and arthritis. We have recently shown that the same compounds in vitro sensitize BN rat peritoneal mast cells for IgE-triggered mediator release and interleukin-4 mRNA production. We wished to test the hypothesis that these agents influence mast cell function via an effect on intracellular reactive oxygen species (ROS) production/redox balance. Mast cells were obtained from BN rats by peritoneal washout. Incubation with HgCl2, gold compounds or D-penicillamine (the latter only in the presence of copper ions) led to the intracellular production of ROS as shown by the oxidative production of the fluorescent compound 2',7'-dichlorofluorescein. Mast cells were more sensitive than splenocytes to this effect. Direct oxidative stress (exposure to H2O2) produced a similar sensitization for mediator release to that caused by HgCl2. Inhibition of ROS formation by desferrioxamine or catalase diminished the enhancement of IgE-mediated serotonin release caused by HgCl2, as did replenishment of intracellular glutathione. 2-Mercaptoethanol exacerbated the toxicity of HgCl2, perhaps due to the formation of a lipophilic complex that enhanced HgCl2 uptake. Blocking of glutathione synthesis increased the toxicity of HgCl2, but also abolished any sensitizing effect on mediator release. These results support three main predictions of our hypothesis: (1) the compounds known to influence mast cell function all lead to the generation of ROS within the mast cell; (2) direct oxidative stress causes sensitization for mediator release by the mast cell; and (3) modulation of ROS production/redox balance within the mast cell modulates the effects of these compounds on mast cell function. The balance of oxidative/antioxidative influences may play an important role in the modulation of mast cell function, particularly in the context of chemically induced autoimmunity.
PubMed ID
9022032 View in PubMed
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[Association of the hSERT and SLC6A4 polymorphic markers of the serotonin transporter gene with schizophrenia in different ethnic groups].

https://arctichealth.org/en/permalink/ahliterature183887
Source
Mol Biol (Mosk). 2003 Jul-Aug;37(4):601-6
Publication Type
Article
Author
A G Zainullina
E B Iur'ev
S R Bikbulatova
E K Khusnutdinova
Author Affiliation
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054 Russia.
Source
Mol Biol (Mosk). 2003 Jul-Aug;37(4):601-6
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Bashkiria - ethnology
Carrier Proteins - genetics - metabolism
Case-Control Studies
Genetic markers
Genetic Predisposition to Disease
Homozygote
Humans
Membrane Glycoproteins - genetics - metabolism
Membrane Transport Proteins
Minisatellite Repeats
Nerve Tissue Proteins
Polymorphism, Genetic
Schizophrenia - epidemiology - etiology - genetics
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins
Abstract
Insertion/deletion and VNTR polymorphisms of the serotonin transporter gene were tested for association with schizophrenia in patients varying in ethnicity. A difference in genetic predisposition was observed for continuous and shift-like schizophrenia forms, the former tending to be associated with genotype 12/12 in Tatars and L/L in Russians.
PubMed ID
12942632 View in PubMed
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Biochemical reconstruction of three cases of death--results of international cooperation.

https://arctichealth.org/en/permalink/ahliterature248433
Source
Forensic Sci. 1978 Jul-Aug;12(1):25-32
Publication Type
Article
Author
J. Raekallio
P L Mäkinen
Source
Forensic Sci. 1978 Jul-Aug;12(1):25-32
Language
English
Publication Type
Article
Keywords
Adult
Autopsy
Female
Finland
Forensic Medicine
Histamine - metabolism
Homicide
Humans
International Cooperation
Male
Postmortem Changes
Serotonin - metabolism
Suicide
Time Factors
Wounds and Injuries - metabolism
Abstract
Biochemical serotonin and histamine determinations were applied to the reconstruction of three suspected homicide cases. To distinguish between ante-mortem and post-mortem wounds and to time the ante-mortem injuries the concentrations of free histamine and serotonin in the wound samples and in the control samples from neighbouring intact skin were examined. The results of these biochemical determinations allowed a reconstruction of the events and one of the three cases was shown to be suicide instead of homicide. The methods can be used at least during the first 4--5 days after death and sometimes even longer. This allows for international cooperation when investigating and reconstructing complicated cases of death.
PubMed ID
711083 View in PubMed
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Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population.

https://arctichealth.org/en/permalink/ahliterature81681
Source
Biol Psychiatry. 2007 Jan 15;61(2):223-30
Publication Type
Article
Date
Jan-15-2007
Author
Christiansen Lene
Tan Qihua
Iachina Maria
Bathum Lise
Kruse Torben A
McGue Matthew
Christensen Kaare
Author Affiliation
Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark. lchristiansen@health.sdu.dk
Source
Biol Psychiatry. 2007 Jan 15;61(2):223-30
Date
Jan-15-2007
Language
English
Publication Type
Article
Keywords
Affect - physiology
Aged
Aged, 80 and over
Denmark
Depressive Disorder - diagnosis - genetics - psychology
Diseases in Twins - diagnosis - genetics - psychology
Female
Genotype
Haplotypes
Humans
Longitudinal Studies
Male
Minisatellite Repeats - genetics
Monoamine Oxidase - genetics
Phosphoric Monoester Hydrolases - genetics
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Receptor, Serotonin, 5-HT2A - genetics
Risk factors
Serotonin - metabolism
Sex Factors
Variation (Genetics) - genetics
Vesicular Monoamine Transport Proteins - genetics
Abstract
BACKGROUND: Depressed mood is a major concern in the elderly, with consequences for morbidity and mortality. Previous studies have demonstrated that genetic factors in depression and subsyndromal depressive symptoms are no less important in the elderly than during other life stages. Variations in genes included in the serotonin system have been suggested as risk factors for various psychiatric disorders but may also serve as candidates for normal variations in mood. METHODS: This study included 684 elderly Danish twins to investigate the influence of 11 polymorphisms in 7 serotonin system genes on the mean level of depression symptomatology assessed over several years, reflecting individuals' underlying mood level. RESULTS: A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. We also found that a specific haplotype in VMAT2, the gene encoding the vesicular monoamine transporter, was significantly associated with depression symptoms in men (p= .007). CONCLUSIONS: These results suggest that variations in genes encoding the components of serotonin metabolism may influence the basic mood level and that different genetic factors may apply in men and women.
PubMed ID
16806099 View in PubMed
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Chlorpromazine-induced alterations in hypothalamic amine metabolism and stress responses in severe cold.

https://arctichealth.org/en/permalink/ahliterature12418
Source
Z Rechtsmed. 1989;102(6):377-90
Publication Type
Article
Date
1989
Author
M L Kortelainen
T. Lapinlampi
J. Hirvonen
Author Affiliation
Department of Forensic Medicine, University of Oulu, Finland.
Source
Z Rechtsmed. 1989;102(6):377-90
Date
1989
Language
English
Publication Type
Article
Keywords
Animals
Arousal - drug effects
Blood Glucose - metabolism
Body Temperature Regulation - drug effects
Chlorpromazine - toxicity
Cold - adverse effects
Dopamine - metabolism
Epinephrine - metabolism
Glycogen - metabolism
Guinea Pigs
Homovanillic Acid - metabolism
Hydroxyindoleacetic Acid - metabolism
Hypothalamus - drug effects
Liver Glycogen - metabolism
Male
Methoxyhydroxyphenylglycol - metabolism
Muscles - drug effects
Neurotransmitter Agents - metabolism
Norepinephrine - metabolism
Research Support, Non-U.S. Gov't
Serotonin - metabolism
Vitreous Body - drug effects
Abstract
To investigate the effects on the central nervous system of severe cold stress with and without chlorpromazine, guinea pigs were treated with chlorpromazine or 0.9% NaCl and exposed to -20 degrees C or +23 degrees C for 1 h. Hypothalamic noradrenaline (NA), dopamine (DA), 5-hydroxy-tryptamine (5-HT), 3-methoxy-4-hydroxyphenyl ethylene glycol (MHPG), homovanillinic acid (HVA) and 5-hydroxy-indoleacetic acid (5-HIAA) were determined by high-performance liquid chromatography. Serum, urinary and vitreous fluid catecholamines, muscle and liver glycogen, and blood glucose were also measured. Chlorpromazine caused distinct hypothermia at -20 degrees C and slight hypothermia at +23 degrees C. The rise in hypothalamic MHPG, 5-HIAA and MHPG/NA and in 5-HIAA/5-HT ratios in the cold indicate increased noradrenergic and serotonergic activity. The latter was inhibited by chlorpromazine and a drug-induced inhibition of noradrenergic neurons could not be ruled out. Chlorpromazine increased the turnover of DA at room temperature and the same tendency was seen in the cold. The hypothermic animals had low serum catecholamines, indicating diminished sympathetic activity. The chlorpromazine-treated cold-exposed animals did not react to the environmental stress by sympathetic activation, as urinary NA and adrenaline were not elevated, but DA was excreted by all the drug-treated animals. Vitreous fluid NA and DA were elevated as an indicator of cold stress, and no drug effect was seen in this fluid.
PubMed ID
2472037 View in PubMed
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Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock.

https://arctichealth.org/en/permalink/ahliterature57439
Source
Shock. 2003 Jan;19(1):71-8
Publication Type
Article
Date
Jan-2003
Author
Abdelouahab Bellou
Henri Lambert
Pierre Gillois
Chantal Montémont
Philippe Gerard
Eliane Vauthier
Jean Sainte-Laudy
Dan Longrois
Jean Louis Guéant
Jean Pierre Mallié
Author Affiliation
Experimental Nephrology Laboratory, Vandoeuvre les Nancy, 54505, France.
Source
Shock. 2003 Jan;19(1):71-8
Date
Jan-2003
Language
English
Publication Type
Article
Keywords
Anaphylaxis - mortality
Animals
Arteries - pathology
Cimetidine - pharmacology
Dihydroergotamine - pharmacology
Dinoprostone - metabolism
Eicosanoids - blood
Enzyme Inhibitors - pharmacology
Heart - drug effects
Histamine - metabolism - pharmacology
Hypotension - metabolism
Leukotriene C4 - metabolism
Male
Myocardium - enzymology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide Synthase - antagonists & inhibitors
Ovalbumin - metabolism
Pressure
Rats
Rats, Inbred BN
Receptors, Serotonin - metabolism
Research Support, Non-U.S. Gov't
Serotonin - metabolism - pharmacology
Thromboxane B2 - metabolism
Time Factors
Abstract
Anaphylactic shock accidents after allergen exposure are frequent. After immunization with ovalbumin (OVA), a common dietary constituent, we evaluated the efficacy of pretreatment with histamine-receptor or serotonin-receptor blockers administered alone or in combination with a nitric oxide synthase inhibitor (L-NAME) on OVA-induced anaphylactic shock in Brown Norway rats. Animals were allocated to the following groups (n = 6 each): control (0.9% saline); diphenydramine (15 mg kg(-1)); cimetidine (20 mg kg(-1)); diphenydramine + cimetidine; dihydroergotamine (50 microg kg(-1)); diphenydramine + cimetidine + dihydroergotamine; L-NAME (100 mg/kg) alone or associated with diphenydramine, cimetidine, diphenydramine + cimetidine, dihydroergotamine, or diphenydramine + cimetidine + dihydroergotamine. Mean arterial blood pressure (MABP), heart rate (HR), and survival time were monitored for 60 min following treatment. The shock was initiated with i.v. OVA. The MABP drop after i.v. OVA was worsened by diphenydramine and was modestly attenuated by cimetidine, dihydroergotamine, or both together. L-NAME potentiated slightly the effects of cimetidine and dihydroergotamine by lessening the initial MABP decrease, but this transient effect was not sufficient to prevent the final collapse or to improve survival time. Decreased vasodilatory (prostaglandins E2), increased vasoconstrictory (thromboxane B2) prostaglandins, and unchanged leukotriene C4 concentrations were contributory to the overall hemodynamic changes. Thus, the combined blockade of vasodilator mediators (histamine, serotonin, and nitric oxide) slowed the MABP drop in anaphylactic shock, but did not improve survival. More studies are needed to understand these discordant effects.
PubMed ID
12558148 View in PubMed
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[Correlative interconnections between impulse activity of aminergic neurons of the brainstem and spectral components of electroencephalogram during action of bemitil]

https://arctichealth.org/en/permalink/ahliterature84263
Source
Fiziol Zh. 2007;53(4):73-7
Publication Type
Article
Date
2007
Author
Kolotilova O I
Pavlenko V B
Koreniuk I I
Kulychenko O M
Fokina Iu O
Source
Fiziol Zh. 2007;53(4):73-7
Date
2007
Language
Ukrainian
Publication Type
Article
Keywords
Action Potentials - drug effects
Animals
Benzimidazoles - pharmacology
Brain Stem - drug effects - metabolism - physiology
Cats
Electroencephalography
Electrons
Female
Locus Coeruleus - drug effects - metabolism - physiology
Male
Neocortex - drug effects - metabolism - physiology
Neurons - drug effects - metabolism - physiology
Norepinephrine - metabolism
Psychotropic Drugs - pharmacology
Serotonin - metabolism
Abstract
Correlative interconnections between frequency of impulse activity of aminergic neurons and neocortex electrical activity during action of bemitil (50 mg/kg) were investigated in 5 cats. It was shown that bemitil affects correlations between frequency of impulses of aminergic neurons and electrical activity of neocortex.
PubMed ID
17902374 View in PubMed
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[Distribution of structural polymorphisms of angiotensin-converting enzyme and serotonin receptor 5-HT2A genes among long-livers of North-Western Russia].

https://arctichealth.org/en/permalink/ahliterature138283
Source
Adv Gerontol. 2011;24(4):620-5
Publication Type
Article
Date
2011
Author
T Iu Smirnova
D L Spivak
G S Iakupova
A G Zakharchuk
I M Spivak
Source
Adv Gerontol. 2011;24(4):620-5
Date
2011
Language
Russian
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Blood Pressure - genetics
Depression - genetics - metabolism
Female
Gene Frequency
Genome-Wide Association Study
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Receptors, Serotonin, 5-HT2 - genetics
Renin-Angiotensin System - genetics
Russia
Serotonin - metabolism
Synaptic Transmission - genetics
Abstract
In the group of long-livers of the North-West of Russia, I/D polymorphism of angiotensin-converting enzyme (ACE) gene and C102T polymorphism of serotonin receptor (5-HT2A) gene were studied. No reliable differences in allele frequency of these genes between long-livers and young people were detected. Nevertheless, highly pronounced difference in the A1/A2 allele frequency of 5-HT2A gene between populations of the North-West of Russia, on the one hand, and of the USA, on the other hand, was discovered (i.e. 0.397(A1), 0.603(A2), and 0.615(A1), 0.385(A2), respectively). Differences of this kind between the two populations deserve special consideration, conditioning the necessity of further detailed analysis of other genes of the serotonin system in the populations of other regions of Russia.
PubMed ID
22550870 View in PubMed
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46 records – page 1 of 5.