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12 records – page 2 of 2.

Serum selenium and risk of cancer. A prospective follow-up of nine years.

https://arctichealth.org/en/permalink/ahliterature234968
Source
Cancer. 1987 Jul 15;60(2):145-8
Publication Type
Article
Date
Jul-15-1987
Author
J. Virtamo
E. Valkeila
G. Alfthan
S. Punsar
J K Huttunen
M J Karvonen
Source
Cancer. 1987 Jul 15;60(2):145-8
Date
Jul-15-1987
Language
English
Publication Type
Article
Keywords
Aged
Finland
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms - blood - epidemiology
Prospective Studies
Risk
Rural Health
Selenium - blood - deficiency
Abstract
The association between serum selenium concentration and the risk of cancer was studied in 1110 men aged 55 to 74 years in two rural areas of Finland. The men were followed-up prospectively for 9 years and there were 109 new cases of cancer, with the cases of the first follow-up year excluded. The serum selenium concentrations were adjusted for age, area, smoking, serum cholesterol, and alcohol intake. The patients had a slightly lower adjusted mean serum selenium than the subjects without cancer at the end of the follow-up (+/- standard error of mean) 53.9 +/- 1.5 and 55.3 +/- 0.5 micrograms/l, respectively. The relative risks of cancer were essentially the same when these were calculated in the tertiles of the serum selenium distribution. Thirty-seven men had a history of cancer at baseline or had cancer diagnosed during the first follow-up year and their adjusted mean serum selenium was 49.4 +/- 2.6 micrograms/l, which was significantly lower (P less than 0.05) than that of the subjects without cancer during the follow-up.
PubMed ID
3594351 View in PubMed
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[The clinical significance of selenium deficiency in patients from the Samara region with cardiovascular diseases and its correction with the preparation Selena].

https://arctichealth.org/en/permalink/ahliterature214360
Source
Eksp Klin Farmakol. 1995 Sep-Oct;58(5):26-8
Publication Type
Article
Author
G P Kuznetsov
P A Lebedev
Source
Eksp Klin Farmakol. 1995 Sep-Oct;58(5):26-8
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Antioxidants - therapeutic use
Cardiovascular Diseases - blood - drug therapy
Drug Evaluation
Female
Humans
Male
Malondialdehyde - blood
Middle Aged
Russia
Selenium - blood - deficiency
Selenomethionine - therapeutic use
Tablets
Abstract
Selenium concentration in blood, glutathionperoxidase (GSH-Px) activity in erythrocytes and lipid peroxides in plasma were studied in patients with ischemic heart disease, hypertrophic (HCMP) and dilated cardiomyopathy (DCMP). Patients with IHD, HCMP and DCMP revealed depressed activity of GSH-Px with activation of lipid peroxides associated with lowered selenium content in blood. The selenium content in blood was lower in patients with severe forms of IHD Daily intake of 300 micrograms selenium with "Selena" during a month increases selenium concentration by 71% in patients with IHD and DCMP. This increase change inversely with primary selenium concentration in plasma. Plasma Malone dialdehyde concentration decreased by 17%. The results obtained suggest participation of selenium in cardiomyopathy and IHD pathogenesis, thus forming a basis for selecting the patients with selenium deficiency for its further correction with "Selena."
PubMed ID
8704583 View in PubMed
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12 records – page 2 of 2.