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Exposure to wear particles generated from studded tires and pavement induces inflammatory cytokine release from human macrophages.

https://arctichealth.org/en/permalink/ahliterature82501
Source
Chem Res Toxicol. 2006 Apr;19(4):521-30
Publication Type
Article
Date
Apr-2006
Author
Lindbom John
Gustafsson Mats
Blomqvist Göran
Dahl Andreas
Gudmundsson Anders
Swietlicki Erik
Ljungman Anders G
Author Affiliation
Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
Source
Chem Res Toxicol. 2006 Apr;19(4):521-30
Date
Apr-2006
Language
English
Publication Type
Article
Keywords
Base Sequence
Cell Line
Cytokines - secretion
DNA Primers
Humans
Inflammation Mediators - metabolism
Macrophages - secretion
Microscopy, Electron, Scanning
Particle Size
Rubber - chemistry
X-Ray Diffraction
Abstract
Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. Lately, wear particles generated from traffic have been recognized to be a major contributing source to the overall particle load, especially in the Nordic countries were studded tires are used. In this work, we investigated the inflammatory effect of PM10 generated from the wear of studded tires on two different types of pavement. As comparison, we also investigated PM10 from a traffic-intensive street, a subway station, and diesel exhaust particles (DEP). Human monocyte-derived macrophages, nasal epithelial cells (RPMI 2650), and bronchial epithelial cells (BEAS-2B) were exposed to the different types of particles, and the secretion of IL-6, IL-8, IL-10, and TNF-alpha into the culture medium was measured. The results show a significant release of cytokines from macrophages after exposure for all types of particles. When particles generated from asphalt/granite pavement were compared to asphalt/quartzite pavement, the granite pavement had a significantly higher capacity to induce the release of cytokines. The granite pavement particles induced cytokine release at the same magnitude as the street particles did, which was higher than what particles from both a subway station and DEP did. Exposure of epithelial cells to PM10 resulted in a significant increase of TNF-alpha secreted from BEAS-2B cells for all types of particles used (DEP was not tested), and the highest levels were induced by subway particles. None of the particle types were able to evoke detectable cytokine release from RPMI 2650 cells. The results indicate that PM10 generated by the wear of studded tires on the street surface is a large contributor to the cytokine-releasing ability of particles in traffic-intensive areas and that the type of pavement used is important for the level of this contribution. Furthermore, the airway inflammatory potential of wear particles from tires and pavement might be of a greater magnitude than that of DEP.
PubMed ID
16608163 View in PubMed
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[Species specificity of fungi isolated from the affected rubber tires and their components]

https://arctichealth.org/en/permalink/ahliterature97041
Source
Mikrobiol Z. 2010 Mar-Apr;72(2):21-9
Publication Type
Article
Author
A I Chuienko
L T Nakonechna
N M Zhdanova
Source
Mikrobiol Z. 2010 Mar-Apr;72(2):21-9
Language
Ukrainian
Publication Type
Article
Keywords
Classification
Environmental monitoring
Fungi - classification - growth & development - isolation & purification
Plasticizers - analysis - chemistry
Rubber - chemistry - standards
Species Specificity
Surface Properties
Abstract
The mycobiota of the rubber technical wares, containing different plasticizers (natural and synthetic) have been investigated. Violation of production technology and storage conditions of the staggered rubber tires, caused their deterioration by the microfungi. Twenty seven (27) species of micromycetes, related to 16 genera were isolated from the surface and internal layers of such objects and their components. A number of species, which can exist theoretically on investigated rubber tires and their components, is calculated. The unfavorableness of the existence conditions for majority of fungi on such substrates is proved. The groups of species, which make the most contribution to deterioration of rubber tires and their components were revealed. These data were obtained using the methods of floristic analysis and computer processing of the data.
PubMed ID
20455438 View in PubMed
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Tire tread wear particles in ambient air--a previously unknown source of human exposure to the biocide 2-mercaptobenzothiazole.

https://arctichealth.org/en/permalink/ahliterature263220
Source
Environ Sci Pollut Res Int. 2014 Oct;21(19):11580-6
Publication Type
Article
Date
Oct-2014
Author
Rozanna Avagyan
Ioannis Sadiktsis
Christoffer Bergvall
Roger Westerholm
Source
Environ Sci Pollut Res Int. 2014 Oct;21(19):11580-6
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Air Pollutants - analysis
Benzothiazoles - analysis
Disinfectants - analysis
Environmental Exposure
Environmental monitoring
Humans
Particulate Matter - analysis
Risk assessment
Rubber - chemistry
Sweden
Urban health
Abstract
Urban particulate matter (PM), asphalt, and tire samples were investigated for their content of benzothiazole and benzothiazole derivates. The purpose of this study was to examine whether wear particles, i.e., tire tread wear or road surface wear, could contribute to atmospheric concentrations of benzothiazole derivatives. Airborne particulate matter (PM10) sampled at a busy street in Stockholm, Sweden, contained on average 17 pg/m(3) benzothiazole and 64 pg/m(3) 2-mercaptobenzothiazole, and the total suspended particulate-associated benzothiazole and 2-mercaptobenzothiazole concentrations were 199 and 591 pg/m(3), respectively. This indicates that tire tread wear may be a major source of these benzothiazoles to urban air PM in Stockholm. Furthermore, 2-mercaptobenzothiazole was determined in urban air particulates for the first time in this study, and its presence in inhalable PM10 implies that the human exposure to this biocide is underestimated. This calls for a revision of the risk assessments of 2-mercaptobenzothiazole exposure to humans which currently is limited to occupational exposure.
PubMed ID
25028318 View in PubMed
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