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Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus.

https://arctichealth.org/en/permalink/ahliterature273707
Source
PLoS One. 2015;10(9):e0138654
Publication Type
Article
Date
2015
Author
Jolene Masters Pedersen
Naja Hulvej Rod
Ingelise Andersen
Theis Lange
Gry Poulsen
Eva Prescott
Rikke Lund
Source
PLoS One. 2015;10(9):e0138654
Date
2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Denmark - epidemiology
Diabetes Mellitus, Type 2 - epidemiology - etiology
Female
Follow-Up Studies
Humans
Life Change Events
Logistic Models
Male
Middle Aged
Multivariate Analysis
Risk Assessment - methods - statistics & numerical data
Risk factors
Stress, Psychological - complications
Surveys and Questionnaires
Time Factors
Young Adult
Abstract
The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment.
The study was based on 4,761 participants from the Copenhagen City Heart Study free of diabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or more events. Multivariate logistic regression models adjusted for age, sex, education and family history of diabetes were used to estimate the association between MLE and T2DM.
In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developing T2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulation of MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associated with risk of T2DM in a dose response manner. There was no evidence that experiencing MLE in both childhood and adult life was more strongly associated with T2DM than experiencing events at only one time point. There was some evidence that being simultaneously exposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) and work MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higher risk of T2DM, as the joint effects were greater than the sum of their individual effects.
Findings from this study suggest that the accumulation of MLE in childhood, private adult life and work life, respectively, are risk factors for developing T2DM.
Notes
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PubMed ID
26394040 View in PubMed
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Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn's disease: results from two large prospective cohort studies.

https://arctichealth.org/en/permalink/ahliterature311448
Source
Gut. 2020 09; 69(9):1637-1644
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Date
09-2020
Author
Hamed Khalili
Niclas Håkansson
Simon S Chan
Ye Chen
Paul Lochhead
Jonas F Ludvigsson
Andrew T Chan
Andrew R Hart
Ola Olén
Alicja Wolk
Author Affiliation
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA hkhalili@mgh.harvard.edu.
Source
Gut. 2020 09; 69(9):1637-1644
Date
09-2020
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Keywords
Age of Onset
Aged
Colitis, Ulcerative - diagnosis - diet therapy - epidemiology - prevention & control
Correlation of Data
Crohn Disease - diagnosis - diet therapy - epidemiology - prevention & control
Diet, Mediterranean
Female
Humans
Incidence
Male
Middle Aged
Patient Compliance - psychology - statistics & numerical data
Proportional Hazards Models
Prospective Studies
Risk Assessment - methods - statistics & numerical data
Risk Reduction Behavior
Surveys and Questionnaires
Sweden - epidemiology
Abstract
To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC).
We conducted a prospective cohort study of 83?147 participants (age range: 45-79 years) enrolled in the Cohort of Swedish Men and Swedish Mammography Cohort. A validated food frequency questionnaire was used to calculate an adherence score to a modified Mediterranean diet (mMED) at baseline in 1997. Incident diagnoses of CD and UC were ascertained from the Swedish Patient Register. We used Cox proportional hazards modelling to calculate HRs and 95%?CI.
Through December of 2017, we confirmed 164 incident cases of CD and 395 incident cases of UC with an average follow-up of 17 years. Higher mMED score was associated with a lower risk of CD (Ptrend=0.03) but not UC (Ptrend=0.61). Compared with participants in the lowest category of mMED score (0-2), there was a statistically significant lower risk of CD (HR=0.42, 95%?CI 0.22 to 0.80) but not UC (HR=1.08, 95%?CI 0.74 to 1.58). These associations were not modified by age, sex, education level, body mass index or smoking (all Pinteraction >0.30). The prevalence of poor adherence to a Mediterranean diet (mMED score=0-2) was 27% in our cohorts, conferring a population attributable risk of 12% for later-onset CD.
In two prospective studies, greater adherence to a Mediterranean diet was associated with a significantly lower risk of later-onset CD.
Notes
CommentIn: Gastroenterology. 2020 Jun;158(8):2304-2305 PMID 32315670
PubMed ID
31900290 View in PubMed
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Alcohol consumption and pancreatitis mortality in Russia.

https://arctichealth.org/en/permalink/ahliterature262739
Source
JOP. 2014 Jul;15(4):365-70
Publication Type
Article
Date
Jul-2014
Author
Yury E Razvodovsky
Source
JOP. 2014 Jul;15(4):365-70
Date
Jul-2014
Language
English
Publication Type
Article
Keywords
Alcohol Drinking - adverse effects
Female
Humans
Male
Pancreatitis - etiology - mortality
Risk Assessment - methods - statistics & numerical data
Risk factors
Russia - epidemiology
Survival Rate - trends
Time Factors
Abstract
Pancreatitis is a major public health problem with high associated economic costs. The incidence of pancreatitis has increased in many European countries in recent decade. Accumulated research and empirical evidence suggests that excessive alcohol consumption is a major risk factor for both acute and chronic pancreatitis.
The aim of this study was to examine the aggregate-level relation between the alcohol consumption and pancreatitis mortality rates in Russia.
Age-standardized sex-specific male and female pancreatitis mortality data for the period 1970-2005 and data on overall alcohol consumption were analyzed by means ARIMA (autoregressive integrated moving average) time series analysis.
Alcohol consumption was significantly associated with both male and female pancreatitis mortality rates: a 1 liter increase in overall alcohol consumption would result in a 7.0% increase in the male pancreatitis mortality rate and in 2.3% increase in the female mortality rate. The results of the analysis suggest that 63.1% of all male pancreatitis deaths and 26.8% female deaths in Russia could be attributed to alcohol. Conclusions The outcomes of this study provide indirect support for the hypothesis that unfavorable mixture of higher overall level of alcohol consumption and binge drinking pattern is an important contributor to the pancreatitis mortality rate in Russian Federation.
PubMed ID
25076345 View in PubMed
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Assessing the effect of treatment duration on the association between anti-diabetic medication and cancer risk.

https://arctichealth.org/en/permalink/ahliterature265055
Source
PLoS One. 2014;9(11):e113162
Publication Type
Article
Date
2014
Author
Anna But
Haining Wang
Satu Männistö
Eero Pukkala
Jari Haukka
Source
PLoS One. 2014;9(11):e113162
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Body mass index
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 2 - drug therapy
Female
Finland - epidemiology
Follow-Up Studies
Health Surveys - methods - statistics & numerical data
Humans
Hypoglycemic agents - therapeutic use
Incidence
Male
Middle Aged
Neoplasms - epidemiology
Registries - statistics & numerical data
Risk Assessment - methods - statistics & numerical data
Risk factors
Smoking
Time Factors
Abstract
Most studies that have evaluated the association between anti-diabetic medication and cancer risk have suffered from methodological drawbacks. To avoid time-related biases, we evaluated the effect of treatment duration on the cancer risk among naive users of anti-diabetic medication as compared to non-users. In addition, we addressed the influence of common risk factors such as smoking and BMI. The study population comprised 23,394 participants of FINRISK surveys. Data on cancer and anti-diabetic medication were linked with the study cohorts. We applied Lexis tabulation to the data and analyzed split records by using Poisson regression. Changes in cancer incidence in relation to treatment duration were examined by modeling the rate ratio (RR). After a median follow-up of 9 years, 53 cancer cases among users of anti-diabetic medication and 1,028 among non-users were diagnosed. No significant difference in cancer risk between users and non-users was observed after adjustment. The RR for all medication regardless of its duration was 1.01 [95% CI 0.75-1.33], and 1.37 [0.94-1.94] for period of 1-4 years. The results were similar for metformin, sulfonylurea, and insulin. This study demonstrates that evaluation of the variation in cancer risk in relation to treatment duration is of particular importance for enhancing the accuracy of conclusions on the link between exposure to anti-diabetic medication and cancer risk.
Notes
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PubMed ID
25419576 View in PubMed
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[Assessment of carcinogenic risks to workers of the main enterprises of the Irkutsk region].

https://arctichealth.org/en/permalink/ahliterature290289
Source
Gig Sanit. 2016; 95(12):1163-7
Publication Type
Journal Article
Author
N V Efimova
V S Rukavishnikov
V A Pankov
A N Perezhogin
S F Shayakhmetov
N M Meshchakova
L G Lisetskaya
Source
Gig Sanit. 2016; 95(12):1163-7
Language
Russian
Publication Type
Journal Article
Keywords
Air Pollutants, Occupational - analysis - toxicity
Carcinogenesis - chemically induced
Carcinogens, Environmental - analysis - toxicity
Chromium - analysis - toxicity
Formaldehyde - analysis - toxicity
Humans
Manufacturing Industry - methods - standards
Occupational Exposure - adverse effects - analysis - prevention & control
Risk Assessment - methods - statistics & numerical data
Risk factors
Siberia - epidemiology
Time
Vinyl Chloride - analysis - toxicity
Abstract
The purpose of research is the assessment of the individual cancer risk (ICR) for workers of the basic occupations in key branches of industry of the Irkutsk region. There was executed the calculation of ICR levels for workers of the basic occupations of the aircraft industry, aluminum smelters and vinyl chloride production plants. The estimation of the exposure for workers was carried out according to long-term time-weighted average concentrations in the air of the working area, for the population - on annual average concentrations in the ambient air. To assess the risk that is not associated with the profession, the dose was calculated for the period of life (70 years). When calculating the toxicant doses in the working area there were used the “standard” indices ofpulmonary ventilation for adults, body weight, the work experience in the contact with carcinogens of 30 years, the number of days in the contact of 240, the duration of the working time 8 or 12 hours (in accordance with the working hours) duration. ICR for the Irkutsk population amounted of 3.08E-04, in Shelekhov - 4.8E-05, Sayansk - 1.1E-05. The amount of risk depends on the content offormaldehyde in all territories and chromium VI in cities of Irkutsk and Shelekhov. ICR for workers of basic occupations of studied plants in dozens of times are higher than for the urban population. Priority carcinogens are: chromium VI, nickel, formaldehyde, silicon dioxide -for the aircraft plant employees; 1,2-dichloretan, vinyl chloride - for the workers of vinyl chloride production plant; benzopyrene - for the aluminum smelter workers.
PubMed ID
29446294 View in PubMed
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Association of blood pressure and hypertension with the risk of Parkinson disease: the National FINRISK Study.

https://arctichealth.org/en/permalink/ahliterature134840
Source
Hypertension. 2011 Jun;57(6):1094-100
Publication Type
Article
Date
Jun-2011
Author
Chengxuan Qiu
Gang Hu
Miia Kivipelto
Tiina Laatikainen
Riitta Antikainen
Laura Fratiglioni
Pekka Jousilahti
Jaakko Tuomilehto
Author Affiliation
Aging Research Center, Karolinska Institutet, Gävlegatan 16, S-11330 Stockholm, Sweden. chengxuan.qiu@ki.se
Source
Hypertension. 2011 Jun;57(6):1094-100
Date
Jun-2011
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects - physiology
Diastole
Female
Finland - epidemiology
Follow-Up Studies
Health Surveys - statistics & numerical data
Humans
Hypertension - complications - drug therapy - physiopathology
Incidence
Male
Middle Aged
Parkinson Disease - epidemiology - etiology - physiopathology
Proportional Hazards Models
Prospective Studies
Registries - statistics & numerical data
Risk Assessment - methods - statistics & numerical data
Risk factors
Sex Factors
Systole
Abstract
Cardiovascular risk factors, such as diabetes mellitus and central obesity, have been associated with Parkinson disease (PD), but data on blood pressure and PD are lacking. We sought to examine the association of blood pressure and hypertension with the risk of PD among men and women. This study consisted of 7 surveys (1972-2002) on representative samples of the general population in Finland (National FINRISK Study). A total number of 59 540 participants (age 25 to 74 years; 51.8% women) who were free of PD and stroke at baseline were prospectively followed until December 31, 2006, to identify incident PD cases using the National Social Insurance Register database. Cox proportional hazards models were constructed to estimate the hazard ratio of PD associated with blood pressure. During a mean follow-up period of 18.8 years (SD: 10.2 years), 423 men and 371 women were ascertained to have developed PD. In women, compared with normotensive subjects (
PubMed ID
21536985 View in PubMed
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Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study.

https://arctichealth.org/en/permalink/ahliterature286263
Source
PLoS One. 2017;12(7):e0181042
Publication Type
Article
Date
2017
Author
Ragnhild E Brandlistuen
Eivind Ystrom
Sonia Hernandez-Diaz
Svetlana Skurtveit
Randi Selmer
Marte Handal
Hedvig Nordeng
Source
PLoS One. 2017;12(7):e0181042
Date
2017
Language
English
Publication Type
Article
Keywords
Adult
Anxiety - chemically induced - psychology
Benzodiazepines - adverse effects
Child Behavior Disorders - chemically induced - psychology
Child, Preschool
Cohort Studies
Depression - chemically induced - psychology
Female
Gestational Age
Humans
Infant
Maternal Age
Norway
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - psychology
Risk Assessment - methods - statistics & numerical data
Risk factors
Siblings
Surveys and Questionnaires
Time Factors
Abstract
During pregnancy, many women experience sleep problems and anxiety that require treatment. The long-term safety for the child of maternal benzodiazepine (BZD) and z-hypnotic use during pregnancy remains controversial.
We conducted a cohort and a sibling control study using data from the Norwegian Mother and Child Cohort Study. Data on use of BZD and z-hypnotics, internalizing and externalizing outcomes, and covariates were collected from mothers at gestational weeks 17 and 30 and when children were 0.5, 1.5, and 3 years of age. The total sample consisted of 71,996 children (19,297 siblings) at 1.5 years and 55,081 children (13,779 siblings) at 3 years. Short-term use was defined as use in one pregnancy period only. Long-term use was defined as use in two or more pregnancy periods. Linear full cohort random-effect and sibling-matched fixed-effect regression models were used to compare internalizing and externalizing behavior in children prenatally exposed compared to those unexposed in the full cohort of pregnancies accounting for family clusters, as well as within sibling clusters comparing pregnancies with discordant exposures. Propensity score (PS) adjustment included variables on indication for use (sleep problems, symptoms of anxiety and depression) and other potential confounding factors.
Long-term prenatal exposure to BZD or z-hypnotics was associated with increased internalizing behavior in crude cohort analyses and at age 1.5 years after PS adjustment in sibling-matched fixed-effect models [ß 0.60, 95% confidence interval 0.17-0.95]. Analyses on specific drug groups showed that prenatal exposure to BZD-anxiolytics was associated with increased internalizing problems at both 1.5 years [ß 0.25, 0.01-0.49] and 3 years [ß 0.26, 0.002-0.52] while exposure to z-hypnotics was not associated with any adverse outcomes after adjustment.
The findings suggest a moderate association between BZD-anxiolytic exposure and child internalizing problems that is not likely due to stable familial confounding factors.
Notes
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PubMed ID
28746341 View in PubMed
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Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies.

https://arctichealth.org/en/permalink/ahliterature153966
Source
Hum Exp Toxicol. 2008 Sep;27(9):721-7
Publication Type
Article
Date
Sep-2008
Author
D. Boers
L. van Amelsvoort
C. Colosio
E. Corsini
S. Fustinoni
L. Campo
C. Bosetti
C. La Vecchia
T. Vergieva
M. Tarkowski
J. Liesivuori
P. Steerenberg
H. van Loveren
Author Affiliation
Department of Epidemiology, Maastricht University, The Netherlands.
Source
Hum Exp Toxicol. 2008 Sep;27(9):721-7
Date
Sep-2008
Language
English
Publication Type
Article
Keywords
Adult
Asthma - etiology - immunology - urine
Bulgaria
Ethylenebis(dithiocarbamates) - poisoning
Ethylenethiourea - analysis
Female
Finland
Fungicides, Industrial - poisoning
Humans
Italy
Male
Multivariate Analysis
Netherlands
Occupational Diseases - etiology - immunology - urine
Occupational Exposure - adverse effects - analysis
Odds Ratio
Pesticides - poisoning
Prospective Studies
Questionnaires
Respiratory Sounds - etiology - immunology
Risk Assessment - methods - statistics & numerical data
Abstract
We conducted a multicenter prospective study to assess the effects of occupational exposure to ethylenebisdithiocarbamate fungicides and/or other pesticides on self-reported asthma and asthmatic symptoms. This multicenter study was conducted among 248 workers exposed to pesticides and 231 non-exposed workers from five field studies. The five field studies were carried out in The Netherlands, Italy, Finland, and two studies in Bulgaria. Subjects constituting this cohort completed a self-administered questionnaire at baseline (before the start of exposure). Ethylenethiourea in urine was determined to assess exposure to ethylenebisdithiocarbamates. In multivariate analyses adjusted for all potential confounders (age, education, residence, smoking, gender, and field study), we found inverse associations, all not statistically significant, between occupational exposure to pesticides and asthma diagnosis (OR 0.41; 95% CI 0.15-1.11), complains of chest tightness (OR 0.60; 95% CI 0.36-1.02), wheeze (OR 0.56; 95% CI 0.32-0.98), asthma attack (OR 0.52; 95% CI 0.12-2.25), and asthma medication (OR 0.79; 95% CI 0.25-2.53). Furthermore, we reported null associations for multivariate analysis using ethylenethiourea as determinant for exposure. Although exposure to pesticides remains a potential health risk, our results do not suggest an association between exposure to ethylenebisdithiocarbamates and/or other pesticides used in our study on asthma and asthmatic symptoms.
PubMed ID
19042955 View in PubMed
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At-fault motor vehicle crash risk in elderly patients treated with antidepressants.

https://arctichealth.org/en/permalink/ahliterature129278
Source
Am J Geriatr Psychiatry. 2011 Dec;19(12):998-1006
Publication Type
Article
Date
Dec-2011
Author
Mark J Rapoport
Brandon Zagorski
Dallas Seitz
Nathan Herrmann
Frank Molnar
Donald A Redelmeier
Author Affiliation
University of Toronto, Toronto, Ontario, Canada. mark.rapoport@sunnybrook.ca
Source
Am J Geriatr Psychiatry. 2011 Dec;19(12):998-1006
Date
Dec-2011
Language
English
Publication Type
Article
Keywords
Accidents, Traffic - statistics & numerical data
Aged
Aged, 80 and over
Antidepressive Agents - administration & dosage - adverse effects
Automobile Driving - statistics & numerical data
Benzodiazepines - administration & dosage - adverse effects
Cholinergic Antagonists - administration & dosage - adverse effects
Drug Therapy, Combination - adverse effects
Female
Humans
Male
Ontario
Risk Assessment - methods - statistics & numerical data
Time Factors
Abstract
To assess whether antidepressant treatment is associated with a temporary increase in the risk of a motor vehicle crash among older adults.
Population-based case-only time-to-event analysis.
Data from transportation and healthcare databases for adults age 65 and older in Ontario, Canada, between January 1, 2000, and October 31, 2007. Consecutive adults who had a motor vehicle crash anytime following their 66th birthday.
The primary exposure variable was treatment with antidepressant medication, and the primary outcome measure was a motor vehicle crash.
A total of 159,678 individuals had a crash during the study, of whom 7,393 (5%) received an antidepressant in the month prior to the crash. The hazard ratio (HR) of crash associated with second-generation antidepressants was 1.10 (95% confidence interval [CI]: 1.07-1.13, ?? = 41.77, df = 1, p
PubMed ID
22123273 View in PubMed
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Biological monitoring and questionnaire for assessing exposure to ethylenebisdithiocarbamates in a multicenter European field study.

https://arctichealth.org/en/permalink/ahliterature153970
Source
Hum Exp Toxicol. 2008 Sep;27(9):681-91
Publication Type
Article
Date
Sep-2008
Author
S. Fustinoni
L. Campo
J. Liesivuori
S. Pennanen
T. Vergieva
Lgpm van Amelsvoort
C. Bosetti
H. Van Loveren
C. Colosio
Author Affiliation
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy. silvia.fustinoni@unimi.it
Source
Hum Exp Toxicol. 2008 Sep;27(9):681-91
Date
Sep-2008
Language
English
Publication Type
Article
Keywords
Adult
Agriculture
Bulgaria
Creatine - urine
Environmental Monitoring - methods - statistics & numerical data
Ethylenebis(dithiocarbamates) - poisoning
Ethylenethiourea - analysis
Female
Finland
Humans
Italy
Male
Middle Aged
Netherlands
Occupational Exposure - adverse effects - analysis
Occupations - classification
Questionnaires
Risk Assessment - methods - statistics & numerical data
Time Factors
Abstract
This study deals with pesticide exposure profile in some European countries with a specific focus on ethylenebisdithiocarbamates (EBDC). In all, 55 Bulgarian greenhouse workers, 51 Finnish potato farmers, 48 Italian vineyard workers, 42 Dutch floriculture farmers, and 52 Bulgarian zineb producers entered the study. Each group was matched with a group of not occupationally exposed subjects. Exposure data were gained through self-administered questionnaires and measuring ethylenethiourea (ETU) in two spot urine samples collected, respectively, before the beginning of seasonal exposure (T0), and after 30 days, at the end of the exposure period (T30). Controls underwent a similar protocol. Study agriculture workers were involved in mixing and loading pesticides, application of pesticide mixture with mechanical or manual equipments, re-entry activities, and cleaning equipments. Chemical workers were involved in synthesis, quality controls, and packing activities. The number of pesticides to whom these subjects were exposed varied from one (zineb production) to eight (potato farmers). The use of personal protective devices was variegate and regarded both aerial and dermal penetration routes. EBDC exposure, assessed by T30 urinary ETU, was found to follow the order: greenhouse workers, zineb producers, vineyard workers, potato farmers, floriculture farmers with median levels of 49.6, 23.0, 11.8, 7.5, and 0.9 microg/g creatinine; the last group having ETU at the same level of controls (approximately 0.5 microg/g creatinine). Among agriculture workers, pesticide application, especially using manual equipment, seems to be the major determinant in explaining internal dose. Although the analysis of self-administered questionnaires evidenced difficulties especially related to lack and/or poor quality of reported data, biological monitoring confirms to be a powerful tool in assessing pesticide exposure.
PubMed ID
19042950 View in PubMed
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