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Multicenter study of strains of respiratory syncytial virus.

https://arctichealth.org/en/permalink/ahliterature226594
Source
J Infect Dis. 1991 Apr;163(4):687-92
Publication Type
Article
Date
Apr-1991
Author
L J Anderson
R M Hendry
L T Pierik
C. Tsou
K. McIntosh
Author Affiliation
Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, Georgia.
Source
J Infect Dis. 1991 Apr;163(4):687-92
Date
Apr-1991
Language
English
Publication Type
Article
Keywords
Antigens, Viral - analysis
Canada
Child
Child, Preschool
Fluorescent Antibody Technique
Humans
Immunoenzyme Techniques
Infant
Respiratory Syncytial Viruses - classification - immunology - isolation & purification
Respirovirus Infections - microbiology
United States
Abstract
Two major groups of respiratory syncytial virus (RSV) strains, A and B, have been identified and their patterns of isolation determined in different communities but not simultaneously in multiple communities. In this study, we tested 483 RSV isolates from 14 university laboratories in the United States and Canada for the 1984/1985 and 1985/1986 RSV seasons; 303 (63%) isolates were group A, 114 (24%) were group B, and 66 (14%) could not be grouped. Isolates were subdivided into six subgroups within group A and three within group B; up to six and often four or more different subgroups were isolated in the same laboratory during the same RSV season. The pattern of group and subgroup isolations varied among laboratories during the same year and between years for the same laboratory. These differences suggest that RSV outbreaks are community, possibly regional, but not national phenomena. The ability to identify group and subgroup differences in isolates is a powerful tool for epidemiologic studies of RSV.
PubMed ID
2010623 View in PubMed
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Occurrence of respiratory syncytial virus subtypes A and B strains in Sweden.

https://arctichealth.org/en/permalink/ahliterature39186
Source
J Med Virol. 1986 Jul;19(3):241-7
Publication Type
Article
Date
Jul-1986
Author
B. Akerlind
E. Norrby
Source
J Med Virol. 1986 Jul;19(3):241-7
Date
Jul-1986
Language
English
Publication Type
Article
Keywords
Aged
Antibodies, Monoclonal - diagnostic use
Antibodies, viral
Child
Electrophoresis, Polyacrylamide Gel
Fluorescent Antibody Technique
Humans
Infant
Radioimmunoassay
Research Support, Non-U.S. Gov't
Respiratory Syncytial Viruses - classification - immunology - isolation & purification
Respirovirus Infections - diagnosis - epidemiology - microbiology
Sweden
Abstract
The subtype characteristics of 22 strains of respiratory syncytial (RS) virus isolated in Sweden were determined by the use of monoclonal antibodies. Eleven antibodies specific for distinct epitopes on five different structural proteins were used in immunofluorescence and radioimmune precipitation assays. One group of 12 isolates were derived from a three-month epidemic during 1984, whereas the other ten virus isolates were recovered during a time period of 13 years (1971-1983). All isolates could be allocated to the previously defined groups of subtype A and B strains of RS virus. During the single epidemic season, five subtype A and seven subtype B strains were found. During the 13-year period a randomly alternating appearance of six subtype A and four subtype B strains was observed. Thus RS virus strains of different subtype characteristics may occur alternately or concomitantly. The possible significance of consecutive infections with RS virus subtypes for immunopathological events deserves further studies.
PubMed ID
3525747 View in PubMed
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