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35 years of marine natural product research in Sweden: Cool molecules and models from cold waters.

https://arctichealth.org/en/permalink/ahliterature283493
Source
Prog Mol Subcell Biol. 2017;55:1-34
Publication Type
Article
Date
2017
Author
Lars Bohlin
Paco Cárdenas
Anders Backlund
Ulf Göransson
Source
Prog Mol Subcell Biol. 2017;55:1-34
Date
2017
Language
English
Publication Type
Article
Keywords
Animals
Aquatic Organisms - chemistry - genetics
Biological Products - chemistry - therapeutic use
Biomedical Research - trends
Cold Temperature
Marine Biology - trends
Oceans and Seas
Porifera - chemistry - genetics
Sweden
Technology, Pharmaceutical - trends
Abstract
Currents efforts in marine biodiscovery have essentially focused on temperate to tropical shallow water organisms. With more than 6000 species of marine plants and animals, the Kosterfjord area has the richest marine biodiversity in Swedish waters, but it remains understudied. The overall objective of our marine pharmacognosy research is to explore and reveal the pharmacological potential of organisms from this poorly explored region. More generally, we wish to understand aspects of structure-activity relationships of chemical interactions in cold-water marine environment (shallow and deep). Our strategy is based on ecologically guided search for compounds through studies of physiology and organism interactions coupled to identification of bioactive molecules guided by especially in vivo assays. The research programme originated in the beginning of the 1980s with a broad screening of Swedish marine organisms using both in vitro and in vivo assays, resulting in isolation and identification of several different bioactive molecules. Two congenerous cyclopeptides, i.e. barettin and 8,9-dihydrobarettin, were isolated from the deep-sea sponge Geodia barretti, and structurally elucidated, guided by their antifouling activity and their affinity to a selection of human serotonin receptors. To optimize the activity a number of analogues of barettin were synthezised and tested for antifouling activity. Within the EU project BlueGenics, two larger homologous peptides, barrettides A and B, were isolated from G. baretti. Also, metabolic fingerprinting combined with sponge systematics was used to further study deep-sea natural product diversity in the genus Geodia. Finally, the chemical property space model 'ChemGPS-NP' has been developed and used in our research group, enabling a more efficient use of obtained compounds and exploration of possible biological activities and targets. Another approach is the broad application of phylogenetic frameworks, which can be used in prediction of where-in which organisms-to search for novel molecules or better sources of known molecules in marine organisms. In a further perspective, the deeper understanding of evolution and development of life on Earth can also provide answers to why marine organisms produce specific molecules.
PubMed ID
28238034 View in PubMed
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110 million dollars vaccine research centre to be built in Saskatoon.

https://arctichealth.org/en/permalink/ahliterature164710
Source
CMAJ. 2007 Mar 13;176(6):751
Publication Type
Article
Date
Mar-13-2007

2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary].

https://arctichealth.org/en/permalink/ahliterature164223
Source
CMAJ. 2007 Apr 10;176(8):S1-13
Publication Type
Article
Date
Apr-10-2007
Author
David C W Lau
James D Douketis
Katherine M Morrison
Irene M Hramiak
Arya M Sharma
Ehud Ur
Author Affiliation
Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta. dcwlau@ucalgary.ca
Source
CMAJ. 2007 Apr 10;176(8):S1-13
Date
Apr-10-2007
Language
English
Publication Type
Article
Keywords
Adult
Algorithms
Anti-Obesity Agents - therapeutic use
Bariatric Surgery
Behavior Therapy
Body mass index
Bulimia Nervosa - psychology
Canada - epidemiology
Child
Depressive Disorder - psychology
Diet
Disease Management
Evidence-Based Medicine
Exercise
Health Behavior
Health education
Humans
Life Style
Obesity - classification - epidemiology - psychology - therapy
Patient care team
Research - trends
Waist-Hip Ratio
Notes
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Comment In: CMAJ. 2007 Nov 20;177(11):139118025434
PubMed ID
17420481 View in PubMed
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[ACTUAL PROBLEMS OF HYGIENE SCIENCE AND PRACTICE IN THE PRESERVATION OF PUBLIC HEALTH].

https://arctichealth.org/en/permalink/ahliterature266203
Source
Gig Sanit. 2015 May-Jun;94(3):5-9
Publication Type
Article
Author
G G Onishchenko
Source
Gig Sanit. 2015 May-Jun;94(3):5-9
Language
Russian
Publication Type
Article
Keywords
Biomedical Research - trends
Humans
Hygiene
Public Health
Russia
Abstract
In the article there are designated the state and actual hygiene tasks on the issue of environmental pollution and its effects on health of the population. There was emphasized the growing importance of chemical contamination of various objects of environment--air water, soil, and living environment. There is presented the analysis of data on different types of treatment of municipal waste in selected countries. There were shown the significance of the developed Guidance on risk assessmentfor public health as a toolfor making sound management decisions, prospects of using of the methodology of epidemiological mapping based on geoinformational technology (GIS technology). There was marked an important role of the younger generation of hygienists and health officers in further work on both preservation and improvement the health of the population in their countries, harmonization of scientific and practical solutions of actual problems of hygiene.
PubMed ID
26302549 View in PubMed
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Adolescent gambling: a review of an emerging field of research.

https://arctichealth.org/en/permalink/ahliterature141553
Source
J Adolesc Health. 2010 Sep;47(3):223-36
Publication Type
Article
Date
Sep-2010
Author
Lynn Blinn-Pike
Sheri Lokken Worthy
Jeffrey N Jonkman
Author Affiliation
Department of Sociology, Indiana University-Purdue University, Indianapolis, Indiana 46202, USA. pikel@iupui.edu
Source
J Adolesc Health. 2010 Sep;47(3):223-36
Date
Sep-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adolescent Behavior - psychology
Adolescent Psychology - methods
Adult
Canada
Child
Forecasting
Gambling - psychology
Great Britain
Humans
Research - trends
United States
Young Adult
Abstract
The purpose of this review was to summarize the research on adolescent gambling with implications for research and prevention or intervention.
The methodology involved a comprehensive and systematic search of "adolescent or youth gambling" in three diverse electronic databases (MedlineAdvanced, PsycINFO, and Sociological Abstracts) and three peer-reviewed journals (International Journal of Gambling Studies, International Journal of Mental Health and Addiction, and Journal of Gambling Issues).
The search resulted in 137 articles (1985-2010) focusing on gambling among youth aged between 9 and 21 years: 103 quantitative, 8 qualitative, and 26 non-empirical. The study of adolescent gambling can be summarized as follows: (a) it is conducted by a relatively small group of researchers in Britain, Canada, and the United States; (b) it is primarily prevalence-focused, quantitative, descriptive, school-based, and atheoretical; (c) it has most often been published in the Journal of Gambling Studies; (d) it is most often examined in relation to alcohol use; (e) it has relatively few valid and reliable screening instruments that are developmentally appropriate for adolescents, and (f) it lacks racially diverse samples.
Four recommendations are presented for both research and prevention or intervention which are as follows: (1) to provide greater attention to the development and validation of survey instruments or diagnostic criteria to assess adolescent problem gambling; (2) to begin to develop and test more gambling prevention or intervention strategies; (3) to not only examine the co-morbidity of gambling and alcohol abuse, but also include other behaviors such as sexual activity; and (4) to pay greater attention to racial and ethnic differences in the study of adolescent gambling.
PubMed ID
20708560 View in PubMed
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Alzheimer's disease. Physician-patient communication.

https://arctichealth.org/en/permalink/ahliterature218088
Source
Can Fam Physician. 1994 Jun;40:1160-8
Publication Type
Article
Date
Jun-1994
Author
J B Orange
D W Molloy
J A Lever
P. Darzins
C R Ganesan
Author Affiliation
Department of Communicative Disorders, University of Western Ontario, London.
Source
Can Fam Physician. 1994 Jun;40:1160-8
Date
Jun-1994
Language
English
Publication Type
Article
Keywords
Aged
Alzheimer Disease - complications - diagnosis - epidemiology
Attitude of Health Personnel
Canada - epidemiology
Communication Disorders - etiology - psychology
Diagnosis, Differential
Forecasting
Geriatric Assessment
Humans
Kinesics
Language
Memory Disorders - etiology - psychology
Physician-Patient Relations
Research - trends
Severity of Illness Index
Abstract
The number of cognitively impaired elderly in Canada has increased greatly during the past two decades; nearly all have Alzheimer's disease (AD). The memory problems and changes in language and communication of these patients place tremendous strain on physicians who are searching for a differential diagnosis and are trying to communicate with them. Reviewing the salient language and communication features of AD patients leads to strategies for improving effective physician-patient communication.
Notes
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PubMed ID
8019193 View in PubMed
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An agenda for research and a plan of action.

https://arctichealth.org/en/permalink/ahliterature233787
Source
Am J Prev Med. 1988;4(4 Suppl):190-1
Publication Type
Article
Date
1988
Author
R. Goldbloom
Author Affiliation
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Source
Am J Prev Med. 1988;4(4 Suppl):190-1
Date
1988
Language
English
Publication Type
Article
Keywords
Canada
Health Plan Implementation
Health planning
Health services research - trends
Humans
Preventive Health Services - trends
United States
PubMed ID
3274749 View in PubMed
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An overview of Aboriginal health research in the social sciences: current trends and future directions.

https://arctichealth.org/en/permalink/ahliterature92194
Source
Int J Circumpolar Health. 2008 Jun;67(2-3):179-89
Publication Type
Article
Date
Jun-2008
Author
Wilson Kathi
Young T Kue
Author Affiliation
Department of Geography, University of Toronto Mississauga, Toronto, Canada. kathi.wilson@utoronto.ca
Source
Int J Circumpolar Health. 2008 Jun;67(2-3):179-89
Date
Jun-2008
Language
English
Publication Type
Article
Keywords
Arctic Regions
Canada
Health Services Research
Health status
Humans
Indians, North American
Inuits
Research - trends
Rural Population
Social Sciences - trends
Urban Population
Abstract
OBJECTIVES: To examine if Aboriginal health research conducted within the field of social sciences reflects the population and geographic diversity of the Aboriginal population. STUDY DESIGN: Review. METHODS: We searched the Web of Science Social Science Citation Index, the Arts and Humanities Citation Index and Scholars Portal for the time period 1995-2005 using search terms to reflect different names used to refer to Canada's Aboriginal peoples. Citations that did not focus on health or Canada were eliminated. Each paper was coded according to 7 broad categories: Aboriginal identity group; geography; age; health status; health determinants; health services; and methods. RESULTS: Based on the 96 papers reviewed, the results show an under-representation of Métis and urban Aboriginal peoples. Most of the papers are on health status and non-medical determinants of health, with a particular focus on chronic conditions and life-style behaviours. Only 6 papers examined traditional approaches to healing and/or access to traditional healers/medicines. A small number involved the use of community-based research methods. CONCLUSIONS: Further research is required to address gaps in the current body of literature. Community-based research studies are necessary to address gaps that are most relevant to Aboriginal peoples.
PubMed ID
18767338 View in PubMed
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[A report on the topic of the basic trends in research in pediatric neurosurgery].

https://arctichealth.org/en/permalink/ahliterature217213
Source
Zh Vopr Neirokhir Im N N Burdenko. 1994 Oct-Dec;(4):45-7
Publication Type
Article
Author
S K Gorelyshev
Source
Zh Vopr Neirokhir Im N N Burdenko. 1994 Oct-Dec;(4):45-7
Language
Russian
Publication Type
Article
Keywords
Brain Neoplasms - surgery
Child
Humans
Neurosurgery - trends
Pediatrics - trends
Research - trends
Russia
PubMed ID
7900479 View in PubMed
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194 records – page 1 of 20.