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Association between duration of untreated psychosis and brain morphology in schizophrenia within the Northern Finland 1966 Birth Cohort.

https://arctichealth.org/en/permalink/ahliterature140885
Source
Schizophr Res. 2010 Nov;123(2-3):145-52
Publication Type
Article
Date
Nov-2010
Author
Matti Penttilä
Erika Jääskeläinen
Marianne Haapea
Päivikki Tanskanen
Juha Veijola
Khanum Ridler
Graham K Murray
Anna Barnes
Peter B Jones
Matti Isohanni
Hannu Koponen
Jouko Miettunen
Author Affiliation
University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, P.O. Box 5000, FIN-90014 Oulu, Finland. mattipen@mail.student.oulu.fi
Source
Schizophr Res. 2010 Nov;123(2-3):145-52
Date
Nov-2010
Language
English
Publication Type
Article
Keywords
Adult
Brain - pathology
Diagnostic and Statistical Manual of Mental Disorders
Female
Finland - epidemiology
Follow-Up Studies
Functional Laterality
Hippocampus - pathology
Humans
Limbic System - pathology
Magnetic Resonance Imaging
Male
Medical Records Systems, Computerized
Psychotic Disorders - etiology - pathology
Regression Analysis
Schizophrenia - diagnosis - pathology
Schizophrenic Psychology
Time Factors
Abstract
Duration of untreated psychosis (DUP) has been linked with poor prognosis and changes in the brain structure in schizophrenia at least at the beginning of the disease, but it is still unknown whether DUP relates to brain morphometry in the longer term. Our aim was to analyze the relation between DUP and the brain structure in schizophrenia in the general population, after several years of illness.
Brains of subjects with psychosis from the Northern Finland 1966 Birth Cohort (NFBC 1966) were scanned with MRI during 1999-2001 after an 11-year follow-up. DUP was assessed from medical records and regressed against global and local tissue density measurements. The brain morphometric and the DUP information were available for 46 subjects with DSM-III-R schizophrenia.
The DUP did not correlate with volumes of the total gray or white matter or the cerebrospinal fluid. The length of DUP associated positively with reduced densities of the right limbic area and the right hippocampus.
Long DUP was slightly associated with reductions of gray matter densities in the limbic area and especially the hippocampus after several years follow-up, supporting the hypothesis that, compared to short DUP, long DUP might be a marker of different disease trajectories including subtle morphometric changes.
PubMed ID
20832996 View in PubMed
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Association between the duration of untreated psychosis and short- and long-term outcome in schizophrenia within the Northern Finland 1966 Birth Cohort.

https://arctichealth.org/en/permalink/ahliterature118694
Source
Schizophr Res. 2013 Jan;143(1):3-10
Publication Type
Article
Date
Jan-2013
Author
Matti Penttilä
Jouko Miettunen
Hannu Koponen
Merja Kyllönen
Juha Veijola
Matti Isohanni
Erika Jääskeläinen
Author Affiliation
University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, Oulu, Finland. mattipen@paju.oulu.fi
Source
Schizophr Res. 2013 Jan;143(1):3-10
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Association
Cohort Studies
Community Health Planning
Female
Finland - epidemiology
Hospitalization - statistics & numerical data
Humans
Longitudinal Studies
Male
Middle Aged
Psychotic Disorders - epidemiology - therapy
Regression Analysis
Schizophrenia - epidemiology - therapy
Sex Factors
Time Factors
Abstract
Long duration of untreated psychosis (DUP) may relate to poor outcome in schizophrenia. However, the associations between DUP and outcomes, particularly in later course of illness, remain unclear. Our aim was to explore the associations between DUP and short- and long-term outcomes in schizophrenia.
Data was collected for subjects with schizophrenia (n=89) in the population-based Northern Finland 1966 Birth Cohort. DUP was obtained from medical records, and its associations with short- (under 2years) and long-term clinical and social outcomes were assessed extending to 20years after the onset of the illness.
Longer DUP predicted longer length of first hospitalisation and increased the risk of rehospitalisation during the first two years. Longer DUP associated with decreased probability of disability pension, smaller amount of time spent in hospital, and higher proportion of time at work during the first 10years of the follow-up.
Regarding early outcome, long DUP may be a modest marker and proxy measure of a more severe clinical phenotype. The divergent results of earlier studies and the association between long DUP and better long-term outcome in our study, indicate that the length of DUP does not necessarily predict poor outcome in long-term follow-up. This may also be due to methodical difficulties, e.g. insufficient power and residual confounding linked to long follow-up studies.
PubMed ID
23178106 View in PubMed
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Brain structure in different psychosis risk groups in the Northern Finland 1986 birth cohort.

https://arctichealth.org/en/permalink/ahliterature262202
Source
Schizophr Res. 2014 Mar;153(1-3):143-9
Publication Type
Article
Date
Mar-2014
Author
Andres Roman-Urrestarazu
Graham K Murray
Anna Barnes
Jouko Miettunen
Erika Jääskeläinen
Pirjo Mäki
Juha Nikkinen
Jukka Remes
Sari Mukkala
Jenni Koivukangas
Markus Heinimaa
Irma Moilanen
John Suckling
Vesa Kiviniemi
Peter B Jones
Juha Veijola
Source
Schizophr Res. 2014 Mar;153(1-3):143-9
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Adult
Brain - pathology
Cohort Studies
Female
Finland
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Prodromal Symptoms
Psychiatric Status Rating Scales
Psychomotor Performance
Psychotic Disorders - classification - pathology
Questionnaires
Regression Analysis
Risk factors
Abstract
We tested the hypothesis that family risk for psychosis (FR) and clinical risk for psychosis (CR) are associated with structural brain abnormalities, with increased deficits in those at both family risk and clinical risk for psychosis (FRCR). The study setting was the Oulu Brain and Mind Study, with subjects drawn from the Northern Finland 1986 Birth Cohort (n=9479) using register and questionnaire based screening, and interviews using the Structured Interview for Prodromal Symptoms. After this procedure, 172 subjects were included in the study, classified as controls (n=73) and three risk groups: FR excluding CR (FR, n=60), CR without FR (CR, n=26), and individuals at both FR and CR (FRCR, n=13). T1-weighted brain scans were acquired and processed in a voxel-based analysis using permutation-based statistics. In the comparison between FRCR versus controls, we found lower grey matter volume (GMV) in a cluster (1689 voxels at -4.00, -72.00, -18.00mm) covering both cerebellar hemispheres and the vermis. This cluster was subsequently used as a mask to extract mean GMV in all four groups: FR had a volume intermediate between controls and FRCR. Within FRCR there was an association between cerebellar cluster brain volume and motor function. These findings are consistent with an evolving pattern of cerebellar deficits in psychosis risk with the most pronounced deficits in those at highest risk of psychosis.
PubMed ID
24462264 View in PubMed
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Changes in alcohol use in relation to sociodemographic factors in early midlife.

https://arctichealth.org/en/permalink/ahliterature275744
Source
Scand J Public Health. 2016 May;44(3):249-57
Publication Type
Article
Date
May-2016
Author
Daniel Vladimirov
Solja Niemelä
Juha Auvinen
Markku Timonen
Sirkka Keinänen-Kiukaanniemi
Leena Ala-Mursula
Jaana Laitinen
Jouko Miettunen
Source
Scand J Public Health. 2016 May;44(3):249-57
Date
May-2016
Language
English
Publication Type
Article
Keywords
Adult
Alcohol drinking - epidemiology
Educational Status
Employment - statistics & numerical data
Female
Finland - epidemiology
Humans
Male
Marital Status - statistics & numerical data
Middle Aged
Prospective Studies
Regression Analysis
Risk factors
Sex Distribution
Abstract
To describe changes in alcohol use in relation to employment, education and relationship statuses in a general population sample in early midlife using prospective birth cohort data.
In the Northern Finland Birth Cohort 1966 (N=5621) alcohol use was studied in participants at two time points: ages 31 and 46. The total mean consumption was calculated and participants were classified into steady drinkers, increasers and reducers based on the change in consumption between the ages of 31 and 46. Multinomial regression analysis was conducted with changes in employment and relationship statuses.
Daily alcohol consumption rose by 30% for men and 40% for women. Persons who were unemployed, single or had a low level of education consumed most. Of the alcohol users, 70% were classified as steady drinkers, 10% as reducers and 20% as increasers. For men, leaving a relationship (odds ratio, OR 1.5; 95% confidence interval, CI: 1.0-2.1) predicted increased alcohol use. The predictors of reducing consumption were entering a relationship for men (OR 1.9; 95% CI: 1.2-2.9) and women (OR 1.9; 95% CI: 1.1-3.1), and leaving a relationship (OR 2.6; 95% CI: 1.6-4.3) for women.
Alcohol consumption among Finns of northern origin does not seem to decline with age. Alcohol usage is fairly stable in the majority of middle-aged people. A substantial proportion of alcohol users engage in either binge or heavy drinking. Gender differences in predictors exist-- changes in relationship status predict a reduction in alcohol usage in women, whereas in men, divorce predicts an increase in usage.
PubMed ID
26685194 View in PubMed
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Early-life origins of schizotypal traits in adulthood.

https://arctichealth.org/en/permalink/ahliterature149354
Source
Br J Psychiatry. 2009 Aug;195(2):132-7
Publication Type
Article
Date
Aug-2009
Author
Jari Lahti
Katri Raïkkönen
Ulla Sovio
Jouko Miettunen
Anna-Liisa Hartikainen
Anneli Pouta
Anja Taanila
Matti Joukamaa
Marjo-Riitta Järvelin
Juha Veijola
Author Affiliation
Department of Psychology, University of Helsinki, FI 00014 University of Helsinki, Finland. jari.lahti@helsinki.fi
Source
Br J Psychiatry. 2009 Aug;195(2):132-7
Date
Aug-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Birth Order
Birth weight
Body Size
Cephalometry - statistics & numerical data
Cohort Studies
Disease Susceptibility
Female
Finland
Humans
Infant
Infant, Newborn
Male
Organ Size
Placenta - anatomy & histology
Pregnancy - psychology
Prenatal Exposure Delayed Effects - epidemiology
Questionnaires
Regression Analysis
Risk factors
Schizotypal Personality Disorder - etiology
Seasons
Sex Factors
Smoking - epidemiology
Abstract
Although schizotypal traits, such as anhedonia and aberrant perceptions, may increase the risk for schizophrenia-spectrum disorders, little is known about early-life characteristics that predict more pronounced schizotypal traits.
To examine whether birth size or several other early-life factors that have been previously linked with schizophrenia predict schizotypal traits in adulthood.
Participants of the Northern Finland 1966 Birth Cohort Study (n = 4976) completed a questionnaire on positive and negative schizotypal traits at the age of 31 years.
Lower placental weight, lower birth weight and smaller head circumference at 12 months predicted elevated positive schizotypal traits in women after adjusting for several confounders (P
PubMed ID
19648543 View in PubMed
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Novelty seeking among adult women is lower for the winter borns compared to the summer borns: replication in a large Finnish birth cohort.

https://arctichealth.org/en/permalink/ahliterature147867
Source
Compr Psychiatry. 2009 Nov-Dec;50(6):562-6
Publication Type
Article
Author
Jayanti Chotai
Matti Joukamaa
Anja Taanila
Dirk Lichtermann
Jouko Miettunen
Author Affiliation
Division of Psychiatry, Department of Clinical Sciences, University of Umeå, 901 85 Umeå, Sweden. jayanti.chotai@vll.se
Source
Compr Psychiatry. 2009 Nov-Dec;50(6):562-6
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Exploratory Behavior
Female
Finland
Humans
Male
Personality Inventory
Regression Analysis
Seasons
Sex Factors
Abstract
Earlier general population studies have shown that novelty seeking (NS) of the Temperament and Character Inventory (TCI) of personality is lower for persons born in winter compared to those born in summer, particularly for women. Here, we investigate if this result can be replicated in another population.
The Northern Finland 1966 Birth Cohort, comprising 4968 subjects (2725 women, 2243 men), was investigated with regard to the temperament dimensions of the TCI and the season of birth.
Novelty seeking and reward dependence (RD) showed significant variations according to the month of birth. We found that women born during winter have significantly lower levels of NS compared to women born during summer, with a minimum for the birth month November and maximum for May. These results are similar to those found in a previous Swedish study. Furthermore, our study showed that men born during spring had significantly lower mean scores of RD compared to men born during autumn, with a minimum for birth month March. This was in contrast to the Swedish study, where the minimum of RD was obtained for the birth month December.
Women born in winter have lower NS as adults compared to women born in summer. Because NS is modulated by dopamine, this study gives further support to the studies in the literature that show that dopamine turnover for those born in winter is higher than for those born in summer.
PubMed ID
19840595 View in PubMed
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Somatic morbidity and criminality: the Northern Finland 1966 Birth Cohort Study.

https://arctichealth.org/en/permalink/ahliterature185884
Source
Forensic Sci Int. 2003 Mar 12;132(1):68-75
Publication Type
Article
Date
Mar-12-2003
Author
Markku Timonen
Taru Mäkikyrö
Jouko Miettunen
Helinä Hakko
Paavo Zitting
Juha Kinnunen
Pirkko Räsänen
Author Affiliation
Department of Psychiatry, University of Oulu, Box 5000, FIN-90014, Oulu Finland. markku.timonen@oulu.fi
Source
Forensic Sci Int. 2003 Mar 12;132(1):68-75
Date
Mar-12-2003
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Comorbidity
Crime - statistics & numerical data
Female
Finland - epidemiology
Forensic Medicine
Humans
Logistic Models
Male
Morbidity
Prospective Studies
Registries
Regression Analysis
Sex Factors
Violence - statistics & numerical data
Abstract
The aim of this study was to investigate the association between adverse physical disorders and violent/non-violent criminal behaviour.
The study material consisted of the large, prospectively followed, unselected and genetically homogeneous Northern Finland 1966 Birth Cohort, the Finnish Hospital Discharge Registers and the National Crime Register (n=10934).
The results of the logistic regression analyses showed that male offenders had statistically significantly more injuries (adj. OR=1.81, 95% CI=1.51-2.17), when compared with males without a criminal history. Violent male offenders exhibited greater morbidity to the diseases of the respiratory system (adj. OR=1.64, 95% CI=1.03-2.60) when compared with non-violent criminals. Female offenders suffered more commonly from poisonings (adj. OR=3.84, 95% CI=1.69-8.72), injuries (adj. OR=2.79, 95% CI=1.67-4.66), infections (adj. OR=1.87, 95% CI=1.16-2.99) and indefinite symptoms (adj. OR=2.02, 95% CI=1.20-3.40) than non-offending females.
At epidemiological level, criminal behaviour seems to be associated especially with an increased risk of injuries for both sexes. The observed increase of the diseases of the respiratory system among violent but not among non-violent males calls for further investigations.
PubMed ID
12689754 View in PubMed
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Tests of linear and nonlinear relations between cumulative contextual risk at birth and psychosocial problems during adolescence.

https://arctichealth.org/en/permalink/ahliterature289793
Source
J Adolesc. 2017 Oct; 60:64-73
Publication Type
Journal Article
Date
Oct-2017
Author
Gilbert R Parra
Gail L Smith
W Alex Mason
Jukka Savolainen
Mary B Chmelka
Jouko Miettunen
Marjo-Riitta Järvelin
Author Affiliation
Department of Child, Youth and Family Studies, University of Nebraska-Lincoln, 135 Mabel Lee Hall, Lincoln, NE 68588, United States. Electronic address: gparra2@unl.edu.
Source
J Adolesc. 2017 Oct; 60:64-73
Date
Oct-2017
Language
English
Publication Type
Journal Article
Keywords
Academic Failure
Adolescent
Adolescent Behavior - psychology
Adolescent Development
Affective Symptoms - epidemiology
Child
Cigarette Smoking - epidemiology
Cohort Studies
Female
Finland
Humans
Infant, Newborn
Juvenile Delinquency - statistics & numerical data
Linear Models
Male
Regression Analysis
Risk factors
Self Report
Underage Drinking - statistics & numerical data
Abstract
This study tested whether there are linear or nonlinear relations between prenatal/birth cumulative risk and psychosocial outcomes during adolescence. Participants (n = 6963) were taken from the Northern Finland Birth Cohort Study 1986. The majority of participants did not experience any contextual risk factors around the time of the target child's birth (58.1%). Even in this low-risk sample, cumulative contextual risk assessed around the time of birth was related to seven different psychosocial outcomes 16 years later. There was some evidence for nonlinear effects, but only for substance-related outcomes; however, the form of the association depended on how the cumulative risk index was calculated. Gender did not moderate the relation between cumulative risk and any of the adolescent psychosocial outcomes. Results highlight the potential value of using the cumulative risk framework for identifying children at birth who are at risk for a range of poor psychosocial outcomes during adolescence.
Notes
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PubMed ID
28755649 View in PubMed
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Use of inverse probability weighting to adjust for non-participation in estimating brain volumes in schizophrenia patients.

https://arctichealth.org/en/permalink/ahliterature129695
Source
Psychiatry Res. 2011 Dec 30;194(3):326-32
Publication Type
Article
Date
Dec-30-2011
Author
Marianne Haapea
Juha Veijola
Päivikki Tanskanen
Erika Jääskeläinen
Matti Isohanni
Jouko Miettunen
Author Affiliation
Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Finland. marianne.haapea@oulu.fi
Source
Psychiatry Res. 2011 Dec 30;194(3):326-32
Date
Dec-30-2011
Language
English
Publication Type
Article
Keywords
Age of Onset
Analysis of Variance
Brain - pathology
Cohort Studies
Disability Evaluation
Female
Finland
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Odds Ratio
Probability
Regression Analysis
Retrospective Studies
Schizophrenia - cerebrospinal fluid - pathology
Abstract
Low participation is a potential source of bias in population-based studies. This article presents use of inverse probability weighting (IPW) in adjusting for non-participation in estimation of brain volumes among subjects with schizophrenia. Altogether 101 schizophrenia subjects and 187 non-psychotic comparison subjects belonging to the Northern Finland 1966 Birth Cohort were invited to participate in a field study during 1999-2001. Volumes of grey matter (GM), white matter (WM) and cerebrospinal fluid (CSF) were compared between the 54 participating schizophrenia subjects and 100 comparison subjects. IPW by illness-related auxiliary variables did not affect the estimated GM and WM mean volumes, but increased the estimated CSF mean volume in schizophrenia subjects. When adjusted for intracranial volume and family history of psychosis, IPW led to smaller estimated GM and WM mean volumes. Especially IPW by a disability pension and a higher amount of hospitalisation due to psychosis had effect on estimated mean brain volumes. The IPW method can be used to improve estimates affected by non-participation by reflecting the true differences in the target population.
PubMed ID
22079654 View in PubMed
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9 records – page 1 of 1.