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Association between plasma fibrinogen concentration and five socioeconomic indices in the Kuopio Ischemic Heart Disease Risk Factor Study.

https://arctichealth.org/en/permalink/ahliterature221733
Source
Am J Epidemiol. 1993 Feb 1;137(3):292-300
Publication Type
Article
Date
Feb-1-1993
Author
T W Wilson
G A Kaplan
J. Kauhanen
R D Cohen
M. Wu
R. Salonen
J T Salonen
Author Affiliation
Human Population Laboratory, Western Consortium for Public Health, Berkeley, CA 94704-1011.
Source
Am J Epidemiol. 1993 Feb 1;137(3):292-300
Date
Feb-1-1993
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - adverse effects - epidemiology
Body mass index
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coffee - adverse effects
Comorbidity
Educational Status
Fibrinogen - analysis
Finland - epidemiology
Humans
Income
Leukocyte Count
Longitudinal Studies
Male
Middle Aged
Myocardial Ischemia - blood - epidemiology - etiology
Occupations
Physical Fitness
Prevalence
Regression Analysis
Risk factors
Smoking - adverse effects - epidemiology
Socioeconomic Factors
Abstract
The association between five socioeconomic indices (lifetime occupation, education, income, ownership of material possessions, and childhood socioeconomic status) and plasma fibrinogen levels was investigated in middle-aged Finnish men who were part of the Kuopio Ischemic Heart Disease Risk Factor Study. The Kuopio Ischemic Heart Disease Risk Factor Study is based on a representative age-stratified sample of 2,682 men aged 42, 48, 54, and 60 years. The data were collected between 1984 and 1989. The present analysis is restricted to the 2,011 men for whom information on fibrinogen and all covariates was available. The covariates were alcohol consumption, body mass index, physical fitness, smoking, coffee consumption, high density lipoprotein cholesterol, low density lipoprotein cholesterol, blood leukocyte count, and prevalent disease (at least one sign of ischemic heart disease, hypertension, diabetes, or previous stroke). An age-adjusted inverse association was found between levels of plasma fibrinogen and four of the five socioeconomic indices: current income, education, lifetime occupation status, and current material possessions. After adjustment for the covariates, the association persisted for education, current income, and lifetime occupation. Analysis of the joint effect of childhood and adult socioeconomic status indicated that those who were economically disadvantaged at both times had the highest fibrinogen levels, but the fibrinogen levels of those who were not poor as adults had no variation by childhood socioeconomic status.
PubMed ID
8452137 View in PubMed
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Carotid atherosclerosis in relation to systolic and diastolic blood pressure: Kuopio Ischaemic Heart Disease Risk Factor Study.

https://arctichealth.org/en/permalink/ahliterature226881
Source
Ann Med. 1991 Feb;23(1):23-7
Publication Type
Article
Date
Feb-1991
Author
R. Salonen
J T Salonen
Author Affiliation
Research Institute of Public Health, University of Kuopio, Finland.
Source
Ann Med. 1991 Feb;23(1):23-7
Date
Feb-1991
Language
English
Publication Type
Article
Keywords
Adult
Arteriosclerosis - epidemiology - ultrasonography
Blood Pressure - physiology
Carotid Artery Diseases - epidemiology - ultrasonography
Coronary Disease - epidemiology
Finland - epidemiology
Humans
Hypertension - epidemiology
Male
Middle Aged
Prevalence
Regression Analysis
Risk factors
Abstract
We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atherosclerosis was assessed with high-resolution B-mode ultrasonography. Men with a casual sitting systolic blood pressure of 175 mmHg or more had a 3.17-fold (95% confidence interval 1.79-5.61) prevalence of intima-media thickening--adjusted for age, smoking, S-LDL-cholesterol, IHD history and diabetes--compared to men with lower systolic pressures. The relative prevalence of carotid plaques in men with raised systolic pressures. The relative prevalence of carotid plaques in men with raised systolic blood pressure was 2.61 (95% confidence interval 1.44-4.72) in relation to men with no lesions. Our findings suggest that systolic but not diastolic hypertension is associated with an increased prevalence of both early and advanced atherosclerotic lesions in carotid arteries.
PubMed ID
2036200 View in PubMed
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Leisure-time physical activity is inversely related to risk factors for coronary heart disease in middle-aged Finnish men.

https://arctichealth.org/en/permalink/ahliterature234626
Source
Eur Heart J. 1987 Oct;8(10):1047-55
Publication Type
Article
Date
Oct-1987
Author
J. Tuomilehto
B. Marti
J T Salonen
E. Virtala
T. Lahti
P. Puska
Author Affiliation
National Public Health Institute, Department of Epidemiology, Helsinki, Finland.
Source
Eur Heart J. 1987 Oct;8(10):1047-55
Date
Oct-1987
Language
English
Publication Type
Article
Keywords
Adult
Coronary Disease - etiology
Cross-Sectional Studies
Finland
Humans
Leisure Activities
Life Style
Male
Middle Aged
Physical Exertion
Regression Analysis
Risk factors
Abstract
Coronary risk factors and levels of physical activity at leisure were measured in a random sample of 3975 men 25-64 years of age residing in four areas of Finland. An index of leisure-time physical activity (LTPA) as the product of weekly exercise sessions times their usual intensity (expressed as metabolic equivalents) was computed. It showed a graded, inverse association with mean arterial blood pressure, smoking and serum thiocyanate, coronary heart disease risk estimate (combining blood pressure, total cholesterol and smoking), and a nonlinear favorable association with serum lipoproteins. In multiple regression analysis, LTPA contributed significantly and independently to the variation in mean arterial pressure; the standardized regression coefficients were -0.06 for LTPA, 0.09 for weekly alcohol consumption, 0.25 for body mass index, 0.25 for age. In the regression of coronary risk estimate, the standardized regression coefficients were -0.19 for LTPA, 0.22 for weekly alcohol consumption, 0.09 for body mass index, 0.15 for age. There was no evidence that LTPA above 2000 kcal of weekly energy expenditure was associated with further reduced coronary risk factor levels. These findings thus support the inverse direction of the association between exercise and coronary risk factors but they also point towards an independent, but modest, role of leisure-time physical activity as a determinant of coronary risk estimate and blood pressure.
PubMed ID
3500045 View in PubMed
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Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion.

https://arctichealth.org/en/permalink/ahliterature49999
Source
Free Radic Res. 1998 Dec;29(6):565-71
Publication Type
Article
Date
Dec-1998
Author
H E Poulsen
S. Loft
H. Prieme
K. Vistisen
J. Lykkesfeldt
K. Nyyssonen
J T Salonen
Author Affiliation
Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark. henrikep@rh.dk
Source
Free Radic Res. 1998 Dec;29(6):565-71
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Antioxidants - analysis
Ascorbic Acid - analysis - blood
Carotenoids - blood
Creatinine - urine
Cytochrome P-450 CYP1A2 - metabolism
DNA Damage
Denmark
Deoxyguanosine - analogs & derivatives - urine
Female
Glutathione Transferase - metabolism
Humans
Male
Middle Aged
Pharmaceutical Preparations - metabolism
Regression Analysis
beta Carotene - analysis - blood
Abstract
Oxidative DNA modification has been implicated in development of certain cancers and 8-oxodG, the most abundant and mutagenic DNA modification, has for some time been considered a biomarker of this activity. Urinary excretion of 8-oxodG over 24h has been used to estimate the rate of damage to DNA, and animal studies have supported this rationale. Reported determinants include tobacco smoking, heavy exercise, environmental pollution and individual oxygen consumption. Samples from three published studies were used to determine the association of urinary 8-oxodG excretion with age, plasma antioxidants, the glutathione-S-transferase phenotype and the activity of the xenobiotic metabolising enzyme CYP1A2. In the age range 35-65 years, age was not related to urinary 8-oxodG excretion, and there were no relations to either the glutathione-S-transferase phenotype or to the plasma antioxidants: vitamin C, alpha-tocopherol, beta-carotene, lycopene or coenzyme Q10. The activity of CYP1A2 showed a significant correlation in two of the three studies, as well as a significant correlation of 0.26 (p
PubMed ID
10098460 View in PubMed
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Physical activity and serum lipids: a cross-sectional population study in eastern Finnish men.

https://arctichealth.org/en/permalink/ahliterature222972
Source
Am J Epidemiol. 1992 Oct 1;136(7):806-18
Publication Type
Article
Date
Oct-1-1992
Author
T A Lakka
J T Salonen
Author Affiliation
Research Institute of Public Health, University of Kuopio, Finland.
Source
Am J Epidemiol. 1992 Oct 1;136(7):806-18
Date
Oct-1-1992
Language
English
Publication Type
Article
Keywords
Adult
Cholesterol - blood
Coronary Disease - blood
Cross-Sectional Studies
Finland
Humans
Lipids - blood
Male
Middle Aged
Multivariate Analysis
Physical Exertion - physiology
Regression Analysis
Triglycerides - blood
Abstract
The authors studied the association of the type, amount, and intensity of physical activity with serum lipids in 2,492 randomly selected eastern Finnish men aged 42-60 years during 1984-1989, controlling for the major confounding factors. High density lipoprotein cholesterol (HDL cholesterol) and HDL2 cholesterol were associated positively and triglycerides inversely with total, occupational, and leisure time activity in a multivariate regression model (p
PubMed ID
1442746 View in PubMed
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Plasma total homocysteine concentration and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.

https://arctichealth.org/en/permalink/ahliterature197388
Source
J Intern Med. 2000 Sep;248(3):217-22
Publication Type
Article
Date
Sep-2000
Author
S. Voutilainen
T A Lakka
P. Hämelahti
T. Lehtimäki
H E Poulsen
J T Salonen
Author Affiliation
Research Institute of Public Health, University of Kuopio, Kuopio, Finland.
Source
J Intern Med. 2000 Sep;248(3):217-22
Date
Sep-2000
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Case-Control Studies
Confounding Factors (Epidemiology)
Coronary Disease - blood - epidemiology
Finland - epidemiology
Homocysteine - blood
Humans
Incidence
Male
Middle Aged
Prospective Studies
Regression Analysis
Risk factors
Abstract
Results from prospective studies concerning the association between plasma total homocysteine (tHcy) concentration and coronary heart disease (CHD) are conflicting. The purpose of this study was to test the hypothesis that plasma tHcy is associated with an increased risk of acute coronary events in middle-aged men.
We investigated this association in a prospective nested case-control study among Eastern Finnish men aged 42-60 years. Plasma tHcy measurements were carried out for 163 men who had an acute coronary event during an average 8 years and 11 months follow-up of the whole cohort and for 163 control subjects. Both the cases and the controls were from a cohort of 2005 men who had no clinical CHD at the Kuopio Ischaemic Heart Disease (KIHD) baseline.
Men in the highest plasma tHcy concentration quarter had no increase in the risk of coronary events compared with men with lower tHcy concentrations (odds ratio = 0.88, 95% confidence interval 0.44-1.76). Average follow-up time before the first coronary event was 4.9 years (SD 3.2) in men in the highest plasma tHcy quarter and 5.5 years (SD 3.1) in men in the three lowest quarters (P = 0.368).
We conclude that plasma tHcy is not associated with an increased risk of coronary events in the middle-aged male population in eastern Finland.
PubMed ID
10971788 View in PubMed
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Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study.

https://arctichealth.org/en/permalink/ahliterature218741
Source
Atherosclerosis. 1994 Mar;106(1):9-19
Publication Type
Article
Date
Mar-1994
Author
G. Alfthan
J. Pekkanen
M. Jauhiainen
J. Pitkäniemi
M. Karvonen
J. Tuomilehto
J T Salonen
C. Ehnholm
Author Affiliation
Department of Nutrition, National Public Health Institute, Helsinki, Finland.
Source
Atherosclerosis. 1994 Mar;106(1):9-19
Date
Mar-1994
Language
English
Publication Type
Article
Keywords
Adult
Arteriosclerosis - blood - epidemiology
Case-Control Studies
Cerebrovascular Disorders - blood - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Homocysteine - blood
Humans
Lipoprotein(a) - blood
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood - epidemiology
Odds Ratio
Prospective Studies
Regression Analysis
Risk factors
Abstract
The relation of serum total homocysteine and lipoprotein(a) (Lp(a)) with the incidence of atherosclerotic disease was investigated among 7424 men and women aged 40-64 years free of atherosclerotic disease at baseline in 1977. During the 9-year follow-up, 134 male and 131 female cases with either myocardial infarction or stroke were identified. For each case a control subject was selected belonging to the same sex and 5-year age group. Serum samples collected in 1977 were stored at -20 degrees C and analyzed in 1991. The mean serum homocysteine concentration of male cases and controls was 9.99 mumol/l and 9.82 mumol/l at baseline and that of female cases and controls 9.58 mumol/l and 9.24 mumol/l, respectively. The median serum Lp(a) concentration of male cases and controls was 73 mg/l and 108 mg/l and that of female cases and controls 113 mg/l and 91 mg/l, respectively. The differences between cases and controls were not statistically significant. There was also no significant association between either homocysteine or Lp(a) and atherosclerotic disease, myocardial infarction or stroke in logistic regression analyses. The odds ratios varied from 1.00 to 1.26 for homocysteine and from 0.81 to 1.06 for Lp(a). The results of this prospective population-based study do not support the hypotheses that serum homocysteine or Lp(a) are risk factors for atherosclerotic disease. The lack of association between serum homocysteine and atherosclerotic disease may be due to the exceptionally low gene frequency predisposing to homocysteinemia in Finland.
PubMed ID
8018111 View in PubMed
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Risk factors for carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study.

https://arctichealth.org/en/permalink/ahliterature230711
Source
Ann Med. 1989 Jun;21(3):227-9
Publication Type
Article
Date
Jun-1989
Author
J T Salonen
K. Seppänen
R. Rauramaa
R. Salonen
Author Affiliation
Department of Community Health and General Practice, University of Kuopio, Finland.
Source
Ann Med. 1989 Jun;21(3):227-9
Date
Jun-1989
Language
English
Publication Type
Article
Keywords
Adult
Carotid Artery Diseases - diagnosis - epidemiology
Cross-Sectional Studies
Finland
Humans
Intracranial Arteriosclerosis - diagnosis - epidemiology
Male
Middle Aged
Regression Analysis
Risk factors
Smoking - adverse effects
Ultrasonography
Abstract
We assessed the severity of carotid atherosclerosis in 412 men from eastern Finland aged 42, 48, 54 or 60 years at examination with B-mode ultrasonography in 1987 in the Kuopi ischaemic Heart Disease Risk Factor Study (KIHD). Thirty-seven per cent of participants had intimal-medial thickening, 10% had plaques and 2% had stenosis. Age (P less than 0.001), cigarette-years (P less than 0.001), serum LDL cholesterol (P = 0.005), low income (P = 0.020) and low alcohol consumption (P = 0.048) had significant partial associations with the severity of carotid atherosclerosis. A linear regression model including these variables and plasma fibrinogen (NS) and serum HDL-cholesterol (NS) accounted for 33% of the variation in atherosclerosis severity. Our data provide further evidence on the role of smoking and LDL-cholesterol in atherosclerosis.
PubMed ID
2669852 View in PubMed
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8 records – page 1 of 1.