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Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men.

https://arctichealth.org/en/permalink/ahliterature190890
Source
Calcif Tissue Int. 2002 Jan;70(1):22-9
Publication Type
Article
Date
Jan-2002
Author
P. Gillberg
H. Olofsson
H. Mallmin
W F Blum
S. Ljunghall
A G Nilsson
Author Affiliation
Department of Medical Sciences, University Hospital, S-75185 Uppsala, Sweden.
Source
Calcif Tissue Int. 2002 Jan;70(1):22-9
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon
Adult
Aged
Aged, 80 and over
Aging - physiology
Bone Density
Femur Neck - metabolism - radiography
Gonadal Steroid Hormones - blood
Humans
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - analysis
Lumbar Vertebrae - metabolism - radiography
Male
Middle Aged
Regression Analysis
Sweden
Abstract
Studies on the hormonal regulation of bone metabolism in men have indicated covariation between insulin-like growth factor-I (IGF-I) and sex hormones with bone mineral density (BMD). In this study the relationships between BMD in total body, lumbar spine, femoral neck, distal and ultradistal (UD) radius and circulating levels of IGFs, IGF binding proteins (IGFBPs), and sex steroids were investigated in 55 Swedish men between 22 and 85 (52 +/- 18, mean +/- SD) years of age. BMD in total body, distal and UD radius, and femoral neck was positively correlated with serum IGF-I (r = 0.31 to 0.49), IGF-II (r = 0.32 to 0.48), IGFBP-3 (r = 0.37 to 0.53), and free androgen index (FAI) (r = 0.32 to 0.40), and negatively with IGFBP-1 (r = -0.37 to -0.41) and IGFBP-2 (r = -0.29 to -0.41) levels. A positive correlation was observed between BMD in femoral neck and estradiol/SHBG ratio (r = 0.34, P = 0.01). Age correlated negatively with serum IGF-I, IGF-II, IGFBP-3, FAI, estradiol/SHBG ratio, and BMD in total body, distal and UD radius, and femoral neck, and positively with IGFBP-1, IGFBP-2, and SHBG levels. According to stepwise multiple regression analyses, a combination of weight, IGFBP-3, and testosterone accounted for 43% of the variation in BMD in femoral neck, 34% in ultradistal radius and 48% in total body (P
PubMed ID
11907704 View in PubMed
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